GEO DataSets

Expression profiling of prostate cancer cell line LNCaP treated for up to 8 hours with the synthetic androgen R1881. LNCaP cells grow slowly in medium devoid of steroids but resume growth upon the addition of androgens. The study aims to identify direct targets of the androgen receptor.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 4 time sets

Platform:

GPL3349

Series:

GSE4027

8 Samples

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(Submitter supplied) cDNA expression arrays on a panel of human prostate cancer xenografts. The xenografts can divided into three groups: 1) androgen-dependent, 2) androgen-independent with functional expression of the androgen receptor, 3) androgen-independent lacking functional expression of the androgen receptor. Four microarrays were performed per xenograft using tissue samples collected in separate experiments. Two samples were taken from intact male mice, whereas the other two samples were taken 1 to 2 weeks after castration. more...

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2384

Platform:

GPL3349

52 Samples

Download data

(Submitter supplied) Time series of the prostate cancer cell line LNCaP, treated for 2, 4, 6 and 8 hours with the synthetic androgen R1881. As control, the cells were cultured for 2, 4, 6 and 8 hours in the presence of the same concentration of solvent (ethanol). With this short treatment time, we aimed to identify mainly direct targets of the androgen receptor. LNCaP has a very low growth rate in steroid stripped medium and resumes growth on addition of androgens. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2034

Platform:

GPL3349

8 Samples

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Analysis of prostate cancer (PC) xenografts collected from male mice up to 14 days after castration. The androgen receptor (AR) plays a pivotal role in the growth and survival of prostate carcinoma. Results provide insight into the role of selective adaptations of the AR pathway in PC progression.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array, log2 ratio, 4 disease state, 3 other, 10 protocol, 14 specimen sets

Platform:

GPL3349

Series:

GSE4084

52 Samples

Download data

(Submitter supplied) To identify molecular changes that occur during prostate tumor progression, we have characterized a series of prostate cancer cell lines isolated at different stages of tumorigenesis from C3(1)/Tag transgenic mice.

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20562

19 Samples

Download data: GPR

(Submitter supplied) In this study, we used microarray analysis to determine gene expression profile changes in the mouse prostate following castration and hormone replacement. We first identified genes with significant expression changes in each of these two processes and then generated a list of androgen responsive genes and a list of genes whose expression were inversely correlated with the presence of androgen. The analysis of this data set is described in Wang et al., Differentiation, 2006 Keywords: Time course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2562

Platform:

GPL81

20 Samples

Download data: CEL

Analysis of prostate of animals following castration and subsequent hormone replacement with testosterone. Castration induces prostate involution, while hormone replacement induces regeneration. Results provide insight into the molecular mechanisms regulating prostatic involution and regeneration.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 protocol sets

Platform:

GPL81

Series:

GSE5901

20 Samples

Download data: CEL

(Submitter supplied) To characterize the molecular features of clinical (Hormone-Refractory Prostate Cancers) HRPCs, we generated the precise gene-expression profiles of 25 clinical HRPCs and 10 hormone-sensitive prostate cancers (HSPCs) by genome-wide cDNA microarrays combining with laser microbeam microdisection. Keywords: disease status analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4747

35 Samples

Download data: TXT

(Submitter supplied) Following androgen ablation treatment for advanced prostate cancer, almost all men relapse after a period of initial response to therapy, which eventually is life threatening. We have previously found that purine-rich element binding protein, PUR alpha, was significantly repressed in androgen-independent prostate cancer cell lines in comparison to an androgen-dependent line. Moreover, over-expressing PURa in androgen-independent prostate cancer cells attenuated their cell proliferation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

Download data: CEL

(Submitter supplied) To identify candidate downstream mRNA target(s) for hsa-miR-616 Affymetrix Human Genome U133 Plus GeneChip 2.0

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

2 Samples

Download data: CEL, CHP

(Submitter supplied) We investigate the direct effects of ARBs on prostate cancer growth and progression.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL4135

8 Samples

Download data: TXT

(Submitter supplied) The mouse prostate tissue exhibits strong power of regeneration, indicating the exisistence of prostate stem cells. Previously we showed that a single mouse prostate cells defined by Lin-CD44+CD133+Sca-1+CD117+ phenotype can generate a prostate after transplantation in vivo. In this study, we compared gene expression profiles of mouse prostate stem cells ( Lin-CD44+CD133+Sca-1+CD117+) and prostate non-stem cells (Lin-CD44-CD133-Sca-1-CD117-).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

9 Samples

Download data: TXT

(Submitter supplied) Androgen deprivation is a standard of care front-line therapy for human prostate cancer, however, majority of patients will eventally develop resistance to androgen deprivation. In this study, using a human prostate cancer xenograft model -LuCaP35, we examiend the gene expression changes after castration.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4120

Platform:

GPL570

10 Samples

Download data: CEL, TXT

NOD/SCID mice with established LuCaP35 xenografts were castrated, and tumors were isolated 4 weeks later. Androgen deprivation regresses androgen-dependent disease, but relapse often occurs in an androgen-independent manner. Results provide insight into the molecular basis of castration resistance.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL570

Series:

GSE33316

10 Samples

Download data: CEL

(Submitter supplied) Transcriptional profiling of the LNCaP cell line treated with R1881 synthetic androgen and/or cycloheximide.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1456

14 Samples

Download data: GPR

(Submitter supplied) Prostate epithelial cells depend on androgens for survival and function. In early prostate cancer, besides survival, androgens also regulated tumor growth, which is exploited by androgen ablation/ blockade therapies in metastatic disease. The aim of the present study was to characterize the role of the androgen receptor pathway in prostate cancer progression and to identify potential disease markers. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10367

21 Samples

Download data: TIFF, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Rattus norvegicus; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8573

8 Samples

Download data: TXT

(Submitter supplied) The goals of this study were to evaluate changes in microRNA expression following androgen treatment.

Organism:

Homo sapiens; Mus musculus; Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL8573

4 Samples

Download data: TXT

(Submitter supplied) The goals of this study were to evaluate changes in microRNA expression following androgen treatment.

Organism:

Homo sapiens; Mus musculus; Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL8573

4 Samples

Download data: TXT

(Submitter supplied) SLC45A3-ELK4 is found in LNCaP and other prostate cancer samples. We used microarrays to detail the global changes of gene expression when LNCaP cells were treated with siRNAs against SLC45A3-ELK4.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

3 Samples

Download data: CEL