GEO DataSets

Analysis of embryonic day 14.5 humeri of runt-related transcription factor 2 (Runx2) deficient animals. Runx2 is an essential factor for skeletogenesis and heterozygous loss causes cleidocranial dysplasia. Results provide insight into the molecular mechanisms underlying skeletogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL82

Series:

GSE4911

4 Samples

Download data: CEL, EXP

(Submitter supplied) We used microarrays to identify genes differentially expressed between mouse RUNX2 -/- and wt embryonic humeri at stage E14.5 Keywords: wildtype versus knockout comparison

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS2184 GDS2185 GDS2186

Platforms:

GPL82 GPL83 GPL81

12 Samples

Download data: CEL, EXP

Analysis of embryonic day 14.5 humeri of runt-related transcription factor 2 (Runx2) deficient animals. Runx2 is an essential factor for skeletogenesis and heterozygous loss causes cleidocranial dysplasia. Results provide insight into the molecular mechanisms underlying skeletogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL83

Series:

GSE4911

4 Samples

Download data: CEL, EXP

Analysis of embryonic day 14.5 humeri of runt-related transcription factor 2 (Runx2) deficient animals. Runx2 is an essential factor for skeletogenesis and heterozygous loss causes cleidocranial dysplasia. Results provide insight into the molecular mechanisms underlying skeletogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL81

Series:

GSE4911

4 Samples

Download data: CEL, EXP

(Submitter supplied) Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Keywords: Genetic modification

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2636

Platform:

GPL339

6 Samples

Download data

Analysis of retinas from postnatal day 7 mutants lacking retinoschisin (RS1h), an animal model for retinoschisis (RS). RS is a recessive retinal dystrophy accompanied by macular disease often resulting in early-onset vision loss. Results provide insight into the pathogenesis of RS.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE5581

6 Samples

Download data

(Submitter supplied) Gene expression profile of Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) reveals murine targets for preclinical development of human prostate cancer therapy In this study, we have generated an open source TRAMP microarray dataset to identify differentially expressed genes from human prostate cancer that have concordant expression in TRAMP tumors, and thereby represent lead targets for preclinical therapy development. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

18 Samples

Download data: CEL

(Submitter supplied) 22q11-deletion syndrome (22q11DS) is a developmental anomaly caused by a microdeletion on human chromosome 22q11. Although mouse models indicated Tbx1 as the gene responsible of the syndrome, the phenotypic spectrum of del22q11 patients is complex suggesting that gene-gene and gene-environment interactions, probably during embryonic development, are crucial in delineating the pathogenesis of 22q11DS. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL3634

14 Samples

Download data

(Submitter supplied) Studies using mice with beta4 nicotinic acetylcholine receptor (nAChR) subunit deficiency (beta4-/- mice) helped reveal the roles of this subunit in bradycardiac response to vagal stimulation, nicotine-induced seizure activity and anxiety. In order to identify genes that might be related to beta4-containing nAChRs activity, we compared the mRNA expression profiles of brains from beta4-/- and wild-type mice using Affymetrix U74Avr2 microarray. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2309

Platform:

GPL81

11 Samples

Download data

Analysis of brains of beta-4 nicotinic acetylcholine receptor (nAChR) subunit null mutants. nAChRs are pentameric ion channels. Results provide insight into the molecular basis of the beta-4 subunit's role in the bradycardic response to vagal stimulation, nicotine-induced seizure, and anxiety.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL81

Series:

GSE5320

11 Samples

Download data

(Submitter supplied) Activity-dependent changes in synapses rely on functional changes in resident proteins and on gene expression. We addressed the relationship between synapse activity and the expression of synaptic genes by comparing RNA levels in the neocortex of normal mice versus synaptically silent munc18-1 null mutants, using microarray expression analysis, quantitative PCR and Northern blotting. We hypothesized that genes under control of synaptic activity are differentially expressed between mutants and controls and found that few synaptic signaling genes were differentially expressed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL3106

11 Samples

Download data

(Submitter supplied) Activity-dependent changes in synapses rely on functional changes in resident proteins and on gene expression. We addressed the relationship between synapse activity and the expression of synaptic genes by comparing RNA levels in the neocortex of normal mice versus synaptically silent munc18-1 null mutants, using microarray expression analysis, quantitative PCR and Northern blotting. We hypothesized that genes under control of synaptic activity are differentially expressed between mutants and controls and found that few synaptic signaling genes were differentially expressed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL3106

4 Samples

Download data

(Submitter supplied) Activity-dependent changes in synapses rely on functional changes in resident proteins and on gene expression. We addressed the relationship between synapse activity and the expression of synaptic genes by comparing RNA levels in the neocortex of normal mice versus synaptically silent munc18-1 null mutants, using microarray expression analysis, quantitative PCR and Northern blotting. We hypothesized that genes under control of synaptic activity are differentially expressed between mutants and controls and found that few synaptic signaling genes were differentially expressed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL3106

6 Samples

Download data

(Submitter supplied) We used manual macrodissection or laser capture microdissection (LCM) to isolate tissue sections of the hippocampus area of Ras-GRF1 wild type and knockout mice brains, and analyzed their transcriptional patterns using commercial oligonucleotide microarrays. Comparison between the transcriptomes of macrodissected and microdissected samples showed that the LCM samples allowed detection of significantly higher numbers of differentially expressed genes, with higher statistical rates of significance. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2816

Platform:

GPL339

6 Samples

Download data: CEL, CHP

Analysis of laser capture microdissected hippocampi of mutants lacking Ras-GRF1. Ras-GRF-1 is a guanine nucleotide exchange factor predominantly expressed in the central nervous system of mammals. Results provide insight into role of Ras-GRF1 in neural processes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE8425

6 Samples

Download data: CEL, CHP

(Submitter supplied) We used a custom Affymetrix GeneChip, the "GLYCOv2" array, to measure differences in gene expression patterns from adult and postnatal day 7 (P7) mouse cerebellum RNA. Keywords = Cerebellum, microarray, development, glycoconjugates, glycosyltransferases, proteoglycans, gene expression Keywords: other

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1854

Platform:

GPL1420

6 Samples

Download data: CEL, EXP

Analysis of cerebellums of postnatal day 7 (P7) and adult animals using an array focusing on glycoconjugates. P7 was chosen for comparison as many differentiation events are peaking at this time. Glycoconjugates are widely distributed throughout the CNS and play an essential role in its development.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL1420

Series:

GSE1712

6 Samples

Download data: CEL, EXP