GEO DataSets

Analysis of lungs of animals exposed to 300 or 600 ug total particulate matter (TPM)/l of cigarette smoke (CS) for up to 13 weeks and allowed to recover 2, 6, or 20 hours after the last exposure. Results provide insight into mechanisms involved in the onset and development of CS-related diseases.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log2 ratio, 2 dose, 3 protocol, 3 time sets

Platform:

GPL3607

Series:

GSE4644

18 Samples

Download data

(Submitter supplied) Gene expression profiling in animal models exposed to cigarette mainstream smoke (CS) shapes up as a promising tool for investigating the molecular mechanisms involved in the onset and development of CS-related disease and may aid in the identification of disease candidate genes. Here we report on differential gene expression in lungs of rats exposed for 2, 7, and 13 weeks to 300 and 600 µg total particulate matter (TPM)/l CS with sacrifice 2, 6, or 20 h after the last exposure. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2188

Platform:

GPL3607

18 Samples

Download data

(Submitter supplied) Expression data from rats exposed to cigarette smoke (CS) at three concentrations (sham, 300µgTPM/l and 600µgTPM/l) for 13 weeks (5d/week; 2hrs/day) after three different recovery times (2hrs, 6hrs and 20hrs after last treatment); lung tissue Keywords: recovery time course and dose dependency

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS2194 GDS2195

Platforms:

GPL341 GPL342

18 Samples

Download data

Analysis of lungs of animals exposed to 300 or 600 ug total particulate matter (TPM)/l of cigarette smoke (CS) for 13 weeks and allowed to recover 2, 6, or 20 hours after the last exposure. Results provide insight into mechanisms involved in the onset and development of CS-related diseases.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 3 dose, 3 protocol sets

Platform:

GPL342

Series:

GSE4516

9 Samples

Download data

Analysis of lungs of animals exposed to 300 or 600 ug total particulate matter (TPM)/l of cigarette smoke (CS) for 13 weeks and allowed to recover 2, 6, or 20 hours after the last exposure. Results provide insight into mechanisms involved in the onset and development of CS-related diseases.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 3 dose, 3 protocol sets

Platform:

GPL341

Series:

GSE4516

9 Samples

Download data

(Submitter supplied) Cigarette smoke (CS) imposes a strong oxidative burden on exposed tissues resulting in a severely disturbed oxidant/antioxidant balance, which in the context of chronic exposure is assumed to be a key contributor to CS-related diseases. Because of its emerging central role in orchestrating the general cellular antioxidant response, the pathway leading to the activation of the transcription factor Nrf2 has received mounting attention over the past decade in investigations aimed at elucidating CS-induced patho-physiological mechanisms. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3622

Platform:

GPL1261

110 Samples

Download data: CEL

Analysis of lungs from transcription factor Nrf2-deficient animals exposed to cigarette smoke (CS) at various doses and for various lengths of time with or without a subsequent recovery period. Results provide insight into the impact of Nrf2 in acute and subchronic smoking scenarios.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 4 dose, 2 genotype/variation, 3 protocol, 3 time sets

Platform:

GPL1261

Series:

GSE18344

110 Samples

Download data: CEL

(Submitter supplied) Although a number of animal model studies have addressed changes in gene expression in the parenchyma and their relationship to emphysema, much less is known about the pathogenesis of cigarette smoke-induced small airway remodeling. In this study, we exposed rat tracheal explants to whole smoke for 15 minutes, and then cultured the explants in air. The airway transcriptome was evaluated using RAE 230_2 GeneChips. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3746

Platform:

GPL1355

47 Samples

Download data: CEL

Analysis of tracheal explants at 2hrs and 24hrs following brief exposure to whole smoke. Some of the explants were pretreated with dexamethasone prior to smoke exposure. Results provide insight into the molecular mechanisms underlying pathogenesis of cigarette smoke-induced small airway remodeling.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 stress, 2 time sets

Platform:

GPL1355

Series:

GSE15563

47 Samples

Download data: CEL

(Submitter supplied) Chronic obstructive pulmonary disease is a smoking-related disease that lacks effective therapies due partly to the poor understanding of disease pathogenesis. The aim of this study was to identify molecular pathways which could be responsible for the damaging consequences of smoking. To do this, we employed recently described bioinformatic methods to analyze differences in global gene expression, which we then related to the pathological changes induced by cigarette smoke (CS). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

209 Samples

Download data: CEL

(Submitter supplied) We have examined the impact of subchronic levels of tobacoo smoke on murine lungs. We have used high density DNA microarray and analysed lung tissues from mice exposed to mainstream tobacco smoke (MTS). Our results reveal induction of inflammatory cytokine interleukin-6 (IL-6) and its antagonist suppressor of cytokine signalling (SOCS3) mRNA in smoking group. We also show that these changes are transient and are reversed completely after a period of cessation of smoking. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2881

39 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10379

1349 Samples

Download data: CEL

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10379

445 Samples

Download data: CEL

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10379

405 Samples

Download data: CEL

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10379

499 Samples

Download data: CEL