Similar studies for GEO DataSets (Select 2729) - GEO DataSets

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Items: 3

Select item 27291.

Cyclophosphamide-resistant chronic myelogenous leukemia cell line

Analysis of chronic myelogenous leukemia (CML) cells resistant to cyclophosphamide (CP), an alkylating anticancer drug. Results provide insight into the molecular basis of CP resistance in CML.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 cell line sets

Platform:: GPL8300
Series:: GSE7114
10 Samples

Download data: CEL

DataSet

Accession:: GDS2729

ID:: 2729

Select item 2000071142.

Comparative analysis of a CML cell line resistant to cyclophosphamide using oligonucleotide arrays and response to TKI

(Submitter supplied) Acquired imatinib resistance in chronic myelogenous leukemia (CML) can be the consequence of mutations in the kinase domain of BCR-ABL or increased protein levels. However, as in other malignancies, acquired resistance to cytostatic drugs is a common reason for treatment failure or disease progression. As a model for drug resistance, we developed a CML cell line resistant to cyclophosphamide (CP). Using oligonucleotide arrays, we examined changes in global gene expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2729
Platform:: GPL8300
10 Samples

Download data: CEL

Series

Accession:: GSE7114

ID:: 200007114

Select item 2000102833.

BCR/ABL1-Dependent Transcriptional Response Reveals Enrichment for Genes Involved in Negative Feedback Regulation

(Submitter supplied) Philadelphia (Ph) chromosome-positive leukemia is characterized by the BCR/ABL1 fusion protein that affects a wide range of signal transduction pathways. The knowledge about its downstream target genes is, however, still quite limited. To identify novel BCR/ABL1-regulated genes we used global gene expression profiling of several Ph-positive and Ph-negative cell lines treated with imatinib. Following imatinib treatment, the Ph-positive cells showed decreased growth, viability, and reduced phosphorylation of BCR/ABL1 and STAT5. more...