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Series GSE7114 Query DataSets for GSE7114
Status Public on Feb 24, 2007
Title Comparative analysis of a CML cell line resistant to cyclophosphamide using oligonucleotide arrays and response to TKI
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Acquired imatinib resistance in chronic myelogenous leukemia (CML) can be the consequence of mutations in the kinase domain of BCR-ABL or increased protein levels. However, as in other malignancies, acquired resistance to cytostatic drugs is a common reason for treatment failure or disease progression. As a model for drug resistance, we developed a CML cell line resistant to cyclophosphamide (CP). Using oligonucleotide arrays, we examined changes in global gene expression. Selected genes were also examined by real-time PCR and flow cytometry. Neither the parent nor the resistant lines had mutations in their ATP binding domain. Filtering genes with a low-base line expression, a total of 239 genes showed significant changes (162 up- and 77 down-regulated) in the resistant clone. Most of the up-regulated genes were associated with metabolism, signal transduction, or encoded enzymes. The gene for aldehyde dehydrogenase 1 was over-expressed more than 2000 fold in the resistant clone. BCR-ABL was expressed in both cell lines to a comparable extent. When exposed to the tyrosine kinase inhibitors imatinib and nilotinib, both lines were sensitive. In conclusion, we found multiple genetic changes in a CML cell line resistant to CP related to metabolism, signal transduction or apoptosis. Despite these changes, the resistant cells retained sensitivity to tyrosine kinase inhibitors.
Keywords: Cell type comparison
 
Overall design A CML cell line and a CP resistant subline were compared by gene array. In addition other markers, the expression of BCR-ABL and the sensitivity to tyrosine kinase inhibitors were tested.
 
Contributor(s) Bao F, Polk P, Nordberg ML, Veillon DM, Sun AW, Deininger M, Murray D, Andersson BS, Munker R
Citation(s) 17403535
Submission date Feb 22, 2007
Last update date Dec 13, 2018
Contact name Reinhold Munker
E-mail(s) rmunke@lsuhsc.edu
Phone 318-675-8770
Fax 318-675-4969
Organization name LSU Health Sciences Center
Department Medicine
Lab Division of Hematology/ Oncology
Street address 1501 Kings Highway
City Shreveport
State/province LA
ZIP/Postal code 71130
Country USA
 
Platforms (1)
GPL8300 [HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Samples (10)
GSM170886 Sensitive Replicate 1
GSM170887 Sensitive Replicate 2
GSM170888 Sensitive Replicate 3
Relations
BioProject PRJNA98421

Table 1: Stringent List of 251 genes (Filters applied:1-Samples were normalized in GeneChip Operating Software; 2-Absolute pivot data was uploaded into GeneSifter where comparisons and t-test were performed; 3-Samples were filtered on t-test p-value ,>.05 filtered out; 4-Samples were filtered on Detection Calls, 100% Absent filtered out; 5-Samples were filtered on Signal ,<500 in both Parental and Resistant Groups filtered out; 6-Samples were filtered on Signal Log Ratio of 2-fold or greater in all comparisons; 7-Samples were filtered on Change Calls, must be at least 80% concordance of calls) header descriptions
Probe Set ID
Sensitive Mean
Sensitive SEM
Resistant Mean
Resistant SEM
Ratio
Direction
p-value
adj p-value
Gene Name
Gene ID
S Signal
S Detection
S Detection p-value
P1 Signal
P1 Detection
P1 Detection p-value
P2 Signal
P2 Detection
P2 Detection p-value
P3 Signal
P3 Detection
P3 Detection p-value
K Signal
K Detection
K Detection p-value
R1 Signal
R1 Detection
R1 Detection p-value
R2 Signal
R2 Detection
R2 Detection p-value
R3 Signal
R3 Detection
R3 Detection p-value
R4 Signal
R4 Detection
R4 Detection p-value
delta Signal
delta Detection
delta Detection p-value
R1 vs S Signal Log Ratio
R1 vs S Change
R1 vs S Change p-value
R2 vs P1 Signal Log Ratio
R2 vs P1 Change
R2 vs P1 Change p-value
R3 vs P2 Signal Log Ratio
R3 vs P2 Change
R3 vs P2 Change p-value
R4 vs P3 Signal Log Ratio
R4 vs P3 Change
R4 vs P3 Change p-value
delta vs K Signal Log Ratio
delta vs K Change
delta vs K Change p-value
Absent Count
Absent %
NC Count
NC %
Increase Count
Increase %
Decrease Count
Decrease %
Gene Symbol
Gene Title
P Avg Signal
R Avg Signal
P<500
R<500
P&R Sum
Binned R2 vs P1 Signal Log Ratio
Binned R1 vs S Signal Log Ratio
Binned R3 vs P2 Signal Log Ratio
Binned R4 vs P3 Signal Log Ratio
Binned delta vs K Signal Log Ratio

Data table
Probe Set ID Sensitive Mean Sensitive SEM Resistant Mean Resistant SEM Ratio Direction p-value adj p-value Gene Name Gene ID S Signal S Detection S Detection p-value P1 Signal P1 Detection P1 Detection p-value P2 Signal P2 Detection P2 Detection p-value P3 Signal P3 Detection P3 Detection p-value K Signal K Detection K Detection p-value R1 Signal R1 Detection R1 Detection p-value R2 Signal R2 Detection R2 Detection p-value R3 Signal R3 Detection R3 Detection p-value R4 Signal R4 Detection R4 Detection p-value delta Signal delta Detection delta Detection p-value R1 vs S Signal Log Ratio R1 vs S Change R1 vs S Change p-value R2 vs P1 Signal Log Ratio R2 vs P1 Change R2 vs P1 Change p-value R3 vs P2 Signal Log Ratio R3 vs P2 Change R3 vs P2 Change p-value R4 vs P3 Signal Log Ratio R4 vs P3 Change R4 vs P3 Change p-value delta vs K Signal Log Ratio delta vs K Change delta vs K Change p-value Absent Count Absent % NC Count NC % Increase Count Increase % Decrease Count Decrease % Gene Symbol Gene Title P Avg Signal R Avg Signal P<500 R<500 P&R Sum Binned R2 vs P1 Signal Log Ratio Binned R1 vs S Signal Log Ratio Binned R3 vs P2 Signal Log Ratio Binned R4 vs P3 Signal Log Ratio Binned delta vs K Signal Log Ratio
37015_at 0.00642 0.001568 17.174999 0.932049 2675.23 Up 7.77E-08 1.37E-05 Human aldehyde dehydrogenase 1 mRNA ALDH1A1 8.9 A 0.926238 19.9 A 0.96066 47.4 A 0.975289 23.9 A 0.993468 39.7 A 0.933168 64279 P 0.000219 67196.8 P 0.000219 64840.1 P 0.000219 86860.7 P 0.000219 86580.4 P 0.000219 12.65 I 0 11.38 I 0 9.66 I 0 11.38 I 0 10.76 I 0 5 50 0 0 5 100 0 0 ALDH1A1 aldehyde dehydrogenase 1 family, member A1 27.96 73951.4 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
39665_at 0.014059 0.003604 1.629749 0.171023 115.92 Up 1.30E-05 0.000297286 Human glycine receptor beta subunit (GLRB) mRNA, complete cds GLRB 44.8 A 0.882879 38 A 0.978134 35.5 A 0.996938 67.7 A 0.715253 120.3 A 0.52062 5054.4 P 0.000468 7539.5 P 0.000322 8128.6 P 0.000468 5393.3 P 0.000322 8866.8 P 0.000322 6.6 I 1.00E-06 7.56 I 1.00E-06 6.56 I 0 5.86 I 0 5.01 I 1.00E-06 5 50 0 0 5 100 0 0 GLRB glycine receptor, beta 61.26 6996.52 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
32747_at 0.037825 0.021726 3.456661 0.083305 91.39 Up 1.78E-10 3.64E-07 Human RNA for mitochondrial aldehyde dehydrogenase I ALDH I (EC 1.2.1.3) ALDH2 70.5 A 0.968664 92.5 A 0.795978 61.5 A 0.992457 535 A 0.67917 56.8 A 0.988553 14941.4 P 0.000805 13338.5 P 0.000805 14891.1 P 0.000959 14740.9 P 0.001602 16269.8 P 0.000673 7.37 I 6.00E-06 7.14 I 6.00E-06 7.6 I 5.00E-06 4.77 I 6.00E-06 8.22 I 5.00E-06 5 50 0 0 5 100 0 0 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 163.26 14836.34 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
40480_s_at 0.012239 0.002991 0.923645 0.1014 75.47 Up 1.88E-05 0.000354046 Homo sapiens c-syn protooncogene mRNA, complete cds FYN 66.5 A 0.964837 96.3 A 0.715253 30 A 0.994357 33.1 A 0.986921 39.4 A 0.993468 2959.3 P 0.000322 4052.3 P 0.000322 5490.2 P 0.000219 3719.6 P 0.000219 3567.6 P 0.000219 5.24 I 0 4.82 I 0 7.52 I 0 6.92 I 0 6.34 I 0 5 50 0 0 5 100 0 0 FYN FYN oncogene related to SRC, FGR, YES 53.06 3957.8 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
1929_at 0.026794 0.0144 1.985909 0.167888 74.12 Up 2.73E-06 0.000113812 HSU83508 Human angiopoietin-1 mRNA, complete cds ANGPT1 13.7 A 0.88284 163.9 A 0.378165 33.6 A 0.765443 336.3 A 0.175949 27.2 A 0.541184 6377.2 P 0.000266 10639 P 0.000266 8003.2 P 0.000266 8387 P 0.000265 9182.9 P 0.000219 7.48 I 0 5.42 I 1.00E-06 6 I 0 4.41 I 1.00E-06 6.72 I 0 5 50 0 0 5 100 0 0 ANGPT1 angiopoietin 1 114.94 8517.86 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
2039_s_at 0.021775 0.006639 1.259766 0.194134 57.85 Up 0.000215187 0.001803511 HUMCSYNA Homo sapiens c-syn protooncogene mRNA, complete cds FYN 111.2 A 0.872355 32.6 A 0.975308 202.2 A 0.781055 62.6 A 0.933135 68.9 A 0.697453 3923.8 P 0.003585 4807.9 P 0.002617 8475.4 P 0.000805 5634.6 P 0.017001 4162.6 P 0.00418 5.26 I 3.00E-06 6.33 I 1.00E-06 5.5 I 1.00E-06 6.25 I 9.00E-06 5.72 I 3.00E-06 5 50 0 0 5 100 0 0 FYN FYN oncogene related to SRC, FGR, YES 95.5 5400.86 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
38047_at 0.009074 0.001925 0.52256 0.085992 57.59 Up 0.000334477 0.002414237 Homo sapiens mRNA for RBP-MS RBPMS 19.7 A 0.997776 26.1 A 0.993468 34.7 A 0.995825 64.1 A 0.990015 52.5 A 0.964837 2171.6 P 0.000805 3520.3 P 0.000322 1951.2 P 0.000468 1634.3 P 0.000388 1841.6 P 0.005643 6.65 I 1.00E-06 6.19 I 0 5.77 I 0 4.82 I 0 4.83 I 7.00E-06 5 50 0 0 5 100 0 0 RBPMS RNA binding protein with multiple splicing 39.42 2223.8 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
39070_at 0.043884 0.020594 2.42416 0.286624 55.24 Up 3.40E-05 0.000469339 Human actin bundling protein (HSN) mRNA, complete cds FSCN1 56.3 A 0.765481 42.4 A 0.602006 501 A 0.250724 62.6 A 0.561639 299.4 A 0.218983 13746.5 P 0.000219 11601.4 P 0.000266 7193.4 P 0.000218 9321.6 P 0.000322 9889.2 P 0.000266 7.53 I 0 6.85 I 2.00E-06 3.13 I 1.90E-05 7.05 I 0.00057 4.43 I 1.00E-06 5 50 0 0 5 100 0 0 FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) 192.34 10350.42 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
37605_at 0.02027 0.003473 1.062969 0.160156 52.44 Up 0.000186335 0.001628441 Human pro-alpha1 type II collagen (COL2A1) gene exons 1-54, complete cds - 70.1 A 0.679198 129.2 A 0.660442 101.7 A 0.781017 43.4 A 0.861235 95.8 A 0.892699 6482.5 P 0.000266 4314.9 P 0.000468 2574.2 P 0.001602 3986.4 P 0.000219 5389.4 P 0.000468 6.01 I 0 5.15 I 1.50E-05 4.48 I 5.00E-06 6.09 I 4.00E-06 5.05 I 1.00E-06 5 50 0 0 5 100 0 0 COL2A1 collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) 88.04 4549.48 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
33412_at 0.093427 0.033467 4.744224 0.748375 50.78 Up 0.000257087 0.00200665 vicpro2.D07.r Homo sapiens cDNA, 5 end LGALS1 401.6 A 0.267428 60.4 A 0.824011 212.1 A 0.781055 442.5 A 0.302547 928 P 0.006532 16940.5 P 0.000219 20538.5 P 0.000219 31563.2 P 0.000219 12975.4 P 0.000219 19347.8 P 0.000219 5.22 I 0 7.82 I 0 6.79 I 0 4.91 I 0 4.37 I 0 4 40 0 0 5 100 0 0 LGALS1 lectin, galactoside-binding, soluble, 1 (galectin 1) 408.92 20273.08 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
32827_at 0.017568 0.006363 0.891996 0.069153 50.77 Up 1.48E-06 6.98E-05 qz41a06.x1 Homo sapiens cDNA, 3 end RRAS2 127.5 A 0.749276 71.2 A 0.918663 17.6 A 0.998111 14.7 A 0.994357 153.5 A 0.882879 3707.3 P 0.000219 4440.3 P 0.000219 3350.2 P 0.000388 3098.9 P 0.000805 4505.7 P 0.000805 4.43 I 0 5.13 I 1.00E-06 6.92 I 0 7.2 I 1.00E-06 4.49 I 5.00E-06 5 50 0 0 5 100 0 0 RRAS2 related RAS viral (r-ras) oncogene homolog 2 76.9 3820.48 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
41531_at 0.006337 0.000631 0.309052 0.048402 48.77 Up 0.000244751 0.00196117 tj34g07.x1 Homo sapiens cDNA, 3 end TM4SF1 20.6 A 0.990056 32.7 A 0.939581 33.7 A 0.99582 22.4 A 0.996415 28.3 A 0.964861 1936.8 P 0.002228 1232.3 P 0.00418 761.9 A 0.089405 1129.9 M 0.05447 1549.7 P 0.003585 6.19 I 1.00E-06 5.13 I 1.10E-05 4.23 I 9.90E-05 6.09 I 6.80E-05 5.6 I 9.20E-05 6 60 0 0 5 100 0 0 TM4SF1 transmembrane 4 superfamily member 1 27.54 1322.12 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
35985_at 0.052442 0.018889 2.50532 0.408245 47.77 Up 0.000322697 0.002373797 Homo sapiens mRNA for KIAA0920 protein, complete cds PALM2-AKAP2 258.4 A 0.795978 45.5 A 0.933135 535.8 A 0.189648 163.1 A 0.824011 148.2 A 0.64131 6009.8 P 0.000219 9470.6 P 0.000219 9515.2 P 0.000266 11565.5 P 0.000219 17672.2 P 0.000219 4.58 I 1.00E-06 6.83 I 0 4.39 I 1.00E-06 6.34 I 0 6.13 I 0 5 50 0 0 5 100 0 0 AKAP2 A kinase (PRKA) anchor protein 2 230.2 10846.66 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
32434_at 0.022587 0.014304 1.077887 0.051769 47.72 Up 4.68E-08 1.08E-05 Homo sapiens mRNA for 80K-L protein, complete cds MARCKS 18.3 A 0.997383 18.9 A 0.92617 341.7 A 0.458809 101.9 A 0.933135 13 A 0.939581 5068 P 0.000219 4877.5 P 0.000219 4111.7 P 0.001141 4449.1 P 0.000959 4563.6 P 0.000219 7.67 I 0 6.84 I 0 3.66 I 8.00E-06 5.96 I 3.00E-06 6.65 I 0 5 50 0 0 5 100 0 0 MARCKS myristoylated alanine-rich protein kinase C substrate 98.76 4613.98 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
38323_at 0.018537 0.010966 0.877019 0.066621 47.31 Up 1.38E-06 6.87E-05 Homo sapiens BAC clone RG113D17 from 7p14-p15 - 21.6 A 0.986908 14.9 A 0.964861 271.8 A 0.781017 36.7 A 0.983 61.3 A 0.749276 3951.9 P 0.000219 4480.2 P 0.000219 3226.1 P 0.000266 3182.4 P 0.000673 3910.5 P 0.000388 7.21 I 0 7.7 I 1.00E-06 3.47 I 4.00E-06 5.78 I 0 5.6 I 0 5 50 0 0 5 100 0 0 CPVL carboxypeptidase, vitellogenic-like 81.26 3750.22 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
39315_at 0.058059 0.017528 2.423565 0.116738 41.74 Up 4.01E-08 1.08E-05 Human mRNA for KIAA0003 gene, complete cds ANGPT1 63.4 A 0.438361 407.7 A 0.150527 86 A 0.732572 291.6 A 0.339558 404.1 A 0.175989 10441 P 0.000266 9456.1 P 0.000219 9042.7 P 0.000266 10562.8 P 0.000219 12574.5 P 0.000219 6.94 I 0 4.03 I 0 6.49 I 1.00E-06 5.05 I 0 4.68 I 1.00E-06 5 50 0 0 5 100 0 0 ANGPT1 angiopoietin 1 250.56 10415.42 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
37641_at 0.031015 0.014759 1.220722 0.074195 39.36 Up 2.67E-07 2.31E-05 Human gene for hepatitis C-associated microtubular aggregate protein p44 - 22.5 A 0.945559 212.6 A 0.602006 22.1 A 0.956032 342.7 M 0.043968 65.5 A 0.88284 5880 P 0.000219 5358.5 P 0.000388 4118.6 P 0.000468 5481 P 0.000266 5317.5 P 0.000266 7.22 I 0 4.29 I 2.00E-06 6.2 I 1.00E-06 3.49 I 1.00E-06 5.67 I 0 4 40 0 0 5 100 0 0 IFI44 interferon-induced protein 44 133.08 5231.12 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
37021_at 0.137294 0.022621 5.097328 0.417092 37.13 Up 2.32E-06 0.000101058 Human mRNA for cathepsin H (EC 3.4.22.16) CTSH 550 A 0.250724 313.2 A 0.458816 921 A 0.284747 688.8 A 0.218945 523.8 A 0.138765 24025.3 P 0.000322 22220.9 P 0.000219 14716.7 P 0.000266 24578.2 P 0.000266 23855.1 P 0.000219 5.05 I 1.00E-06 5.54 I 1.00E-06 3.54 I 1.00E-06 5.32 I 1.00E-06 5.04 I 0 5 50 0 0 5 100 0 0 CTSH cathepsin H 599.36 21879.24 0 0 0 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
32889_at 0.037065 0.012943 1.359886 0.070809 36.69 Up 7.91E-08 1.37E-05 td18e08.x1 Homo sapiens cDNA, 3 end RPIB9 227.3 A 0.581931 87.8 A 0.795978 350.7 A 0.561649 23.4 A 0.849513 124.8 A 0.520623 5019.8 P 0.000266 5866.8 P 0.000266 6835.5 P 0.000266 5822.1 P 0.000266 5609.3 P 0.000219 4.23 I 0 6.25 I 1.00E-06 3.78 I 1.00E-06 7.34 I 1.00E-06 5.35 I 0 5 50 0 0 5 100 0 0 RPIB9 Rap2-binding protein 9 162.8 5830.7 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x
1837_at 0.011053 0.004062 0.396152 0.048516 35.84 Up 4.74E-05 0.000583594 Ras-Like Protein Tc21 - 27.4 A 0.849513 112.6 A 0.810313 15.3 A 0.975289 38.8 A 0.861235 43.7 A 0.892737 1630.3 P 0.000959 2187.2 P 0.000562 1797.3 P 0.000562 1010.4 P 0.000266 1827.6 P 0.001354 5.31 I 1.20E-05 3.57 I 1.00E-06 5.54 I 5.00E-06 5.16 I 1.00E-06 5.39 I 1.20E-05 5 50 0 0 5 100 0 0 --- --- 47.56 1690.56 1 0 1 0.99 < x 0.99 < x 0.99 < x 0.99 < x 0.99 < x

Total number of rows: 251

Table truncated, full table size 125 Kbytes.




Table 2: Filtered List header descriptions
Probe Set ID
P Avg Signal
R Avg Signal
P<500
R<500
Sum of D2 & E2
Sensitive Mean
Sensitive SEM
Resistant Mean
Resistant SEM
Ratio
Direction
p-value
adj p-value
Gene Name
Gene ID
S Signal
S Detection
S Detection p-value
P1 Signal
P1 Detection
P1 Detection p-value
P2 Signal
P2 Detection
P2 Detection p-value
P3 Signal
P3 Detection
P3 Detection p-value
K Signal
K Detection
K Detection p-value
R1 Signal
R1 Detection
R1 Detection p-value
R2 Signal
R2 Detection
R2 Detection p-value
R3 Signal
R3 Detection
R3 Detection p-value
R4 Signal
R4 Detection
R4 Detection p-value
delta Signal
delta Detection
delta Detection p-value
R1 vs S Signal Log Ratio
R1 vs S Change
R1 vs S Change p-value
R2 vs P1 Signal Log Ratio
R2 vs P1 Change
R2 vs P1 Change p-value
R3 vs P2 Signal Log Ratio
R3 vs P2 Change
R3 vs P2 Change p-value
R4 vs P3 Signal Log Ratio
R4 vs P3 Change
R4 vs P3 Change p-value
delta vs K Signal Log Ratio
delta vs K Change
delta vs K Change p-value
Absent Count
Absent %
NC Count
NC %
Increase Count
Increase %
Decrease Count
Decrease %
Gene Symbol
Gene Title

Data table
Probe Set ID P Avg Signal R Avg Signal P<500 R<500 Sum of D2 & E2 Sensitive Mean Sensitive SEM Resistant Mean Resistant SEM Ratio Direction p-value adj p-value Gene Name Gene ID S Signal S Detection S Detection p-value P1 Signal P1 Detection P1 Detection p-value P2 Signal P2 Detection P2 Detection p-value P3 Signal P3 Detection P3 Detection p-value K Signal K Detection K Detection p-value R1 Signal R1 Detection R1 Detection p-value R2 Signal R2 Detection R2 Detection p-value R3 Signal R3 Detection R3 Detection p-value R4 Signal R4 Detection R4 Detection p-value delta Signal delta Detection delta Detection p-value R1 vs S Signal Log Ratio R1 vs S Change R1 vs S Change p-value R2 vs P1 Signal Log Ratio R2 vs P1 Change R2 vs P1 Change p-value R3 vs P2 Signal Log Ratio R3 vs P2 Change R3 vs P2 Change p-value R4 vs P3 Signal Log Ratio R4 vs P3 Change R4 vs P3 Change p-value delta vs K Signal Log Ratio delta vs K Change delta vs K Change p-value Absent Count Absent % NC Count NC % Increase Count Increase % Decrease Count Decrease % Gene Symbol Gene Title
36367_at 573.96 31.72 0 1 1 0.131476 0.013732 0.007297 0.001661 18.02 Down 1.89E-05 0.000354046 Human clone 23599 mRNA sequence PCDH11X 765.5 P 0.024711 424.1 A 0.175949 633.4 A 0.32083 606.3 A 0.127645 440.5 A 0.204022 15.2 A 0.978134 20.6 A 0.956032 29.5 A 0.926204 33.7 A 0.975308 59.6 A 0.951005 -5.1 D 0.999941 -3.64 D 0.99971 -4.12 NC 0.994506 -4.29 NC 0.996147 -2.29 D 0.999186 9 90 2 40 0 0 3 60 PCDH11X protocadherin 11 X-linked
38172_at 119.84 624.62 1 0 1 0.027484 0.012121 0.145271 0.016594 5.29 Up 0.000438056 0.002917997 Homo sapiens DNA, chromosome 21q22.2, PAC clone 25P16 complete sequence, encoding carbonyl reductase and carbonyl reductase 3 (complete cds) - 41.1 A 0.999041 63.3 A 0.872394 74.6 A 0.960635 89.8 A 0.872355 330.4 A 0.541191 616.5 P 0.005636 673.4 A 0.098054 355.6 A 0.32083 814 A 0.189648 663.6 A 0.07383 3.55 I 1.00E-06 3.34 NC 0.011266 1.84 NC 0.029473 3.7 I 0.001566 0.9 I 0.000955 9 90 2 40 3 60 0 0 CBR3 carbonyl reductase 3
215_g_at 317.86 1291.96 1 0 1 0.073465 0.024078 0.302001 0.049922 4.11 Up 0.003329008 0.01247248 HUMHOX7 Homo sapiens (region 7) homeobox protein (HOX7) mRNA, complete cds MSX1 135.9 A 0.918663 540.1 A 0.621816 137.5 A 0.939581 177.5 A 0.781017 598.3 A 0.250724 1993.6 P 0.011447 992.2 A 0.089405 896 A 0.302547 1508.2 A 0.150527 1069.8 A 0.35869 3.17 I 0 1.36 I 0.00224 3.12 MI 0.002825 2.97 NC 0.018117 0.74 NC 0.221643 9 90 2 40 2 40 0 0 MSX1 msh homeo box homolog 1 (Drosophila)
41036_at 626.3 1550.68 0 0 0 0.144092 0.045219 0.364668 0.064909 2.53 Up 0.023619723 0.05564785 dJ1170K4.1 (novel protein similar to KIAA0176 and mouse, worm and fly proteins) - 398.6 A 0.378184 352.6 A 0.397994 983.8 A 0.35869 1197.7 A 0.32083 198.8 A 0.67917 1665.4 A 0.07383 2173.3 M 0.05447 1701.5 A 0.081337 572 A 0.458816 1641.2 A 0.107301 1.59 I 4.00E-05 2.13 I 6.80E-05 0.63 NC 0.051889 -1.42 NC 0.772757 2.61 I 0.000177 9 90 2 40 3 60 0 0 FLJ12242 hypothetical protein FLJ12242
35792_at 56.9 1119.98 1 0 1 0.013016 0.002203 0.259227 0.035134 19.92 Up 0.000113317 0.001135951 Human lysophospholipase homolog (HU-K5) mRNA, complete cds MGLL 95.3 A 0.918698 44.2 A 0.968664 54.4 A 0.986921 53.4 A 0.945559 37.2 A 0.951033 1004.7 A 0.098054 937.4 A 0.117121 671.4 A 0.339558 1358.5 A 0.089369 1627.9 P 0.021849 3.86 I 0.000467 4.55 I 0.000868 4.05 NC 0.027053 4.97 I 1.10E-05 5.22 I 0.00057 9 90 1 20 4 80 0 0 MGLL monoglyceride lipase
40968_at 99.62 734.98 1 0 1 0.022864 0.002021 0.172215 0.041476 7.53 Up 0.007016676 0.02150719 Homo sapiens mRNA for STAT induced STAT inhibitor-3, complete cds SOCS3 109 A 0.910595 77.8 A 0.960635 108.8 A 0.960635 123.1 A 0.910595 79.4 A 0.951005 565.5 A 0.284747 1282.9 M 0.048995 492.5 A 0.234557 350.7 A 0.715253 983.3 A 0.089405 3.02 I 0.000693 4.17 I 4.00E-05 2.33 I 0.001226 1.73 NC 0.170131 3.86 I 0.000357 9 90 1 20 4 80 0 0 SOCS3 suppressor of cytokine signaling 3
37411_at 1056.72 422.48 0 1 1 0.24325 0.023768 0.097866 0.040176 2.49 Down 0.014347922 0.03723541 Human mRNA for KIAA0050 gene, complete cds CENTB1 956 A 0.060419 1073.6 A 0.107263 983.6 A 0.339558 1418.6 P 0.039365 851.8 A 0.175989 514.8 A 0.438361 316.3 A 0.561639 110.6 A 0.926204 1071 A 0.458816 99.7 A 0.837105 -1.43 D 0.999159 -1.82 D 0.99943 -2.75 NC 0.996371 -0.69 D 0.999997 -2.54 D 0.99978 9 90 1 20 0 0 4 80 CENTB1 centaurin, beta 1
34376_at 67.48 1022.08 1 0 1 0.015523 0.002357 0.235816 0.043808 15.19 Up 0.001025139 0.005307364 Homo sapiens PKIG mRNA for protein kinase inhibitor gamma, complete cds PKIG 41.8 A 0.978134 59.9 A 0.980696 57.1 A 0.985077 76.8 A 0.978151 101.8 A 0.795978 831.8 A 0.060419 729.8 A 0.07383 615.1 A 0.234557 1180.3 P 0.035163 1753.4 A 0.07383 4.23 I 0.000107 3.95 I 8.00E-06 3.66 I 0.001566 4.35 I 6.80E-05 3.36 I 0.000841 9 90 0 0 5 100 0 0 PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
36811_at 82.48 898.3 1 0 1 0.018856 0.013667 0.209024 0.026607 11.09 Up 0.000218829 0.00181913 Human lysyl oxidase-like protein gene - 22.2 A 0.94553 15.6 A 0.968664 16.5 A 0.999438 36.3 A 0.980713 321.8 A 0.732537 1101.1 P 0.011447 562.5 A 0.107301 842.6 A 0.066865 1216.1 A 0.107301 769.2 A 0.081337 5.05 I 9.00E-06 4.2 I 0.000382 5.12 I 4.00E-05 4.66 I 0.000896 1.22 I 7.90E-05 9 90 0 0 5 100 0 0 LOXL1 lysyl oxidase-like 1
1748_s_at 295.68 3083.2 1 0 1 0.067654 0.034808 0.721167 0.062223 10.66 Up 1.62E-05 0.000329755 CH19HHR23 Homo sapiens DNA from chromosome 19p13.2 cosmids R31240, R30272 and R28549 containing the EKLF, GCDH, CRTC, and RAD23A genes, genomic sequence - 138.8 A 0.892699 116.2 A 0.951005 162.7 A 0.939581 154.6 A 0.918663 906.1 A 0.438361 3586.2 A 0.060419 2722.5 A 0.060419 3667.1 P 0.024711 2454.3 A 0.204022 2985.9 A 0.127645 5.09 I 1.20E-05 4.72 I 1.40E-05 4.65 I 0 4.13 I 0.000191 1.34 MI 0.002517 9 90 0 0 4 80 0 0 KLF1 Kruppel-like factor 1 (erythroid)
41743_i_at 47.5 598.96 1 0 1 0.010924 0.003535 0.140004 0.020895 12.82 Up 0.000292372 0.002182122 Homo sapiens FIP2 alternatively translated mRNA, complete cds OPTN 23.8 A 0.889617 46 A 0.860646 24.8 A 0.980408 35.6 A 0.924084 107.3 A 0.844552 456.8 A 0.155448 713.4 P 0.016523 769.2 P 0.019622 323 A 0.324822 732.4 A 0.066419 4.39 NC 0.013131 4.04 I 0.000218 4.41 I 0.000318 3.64 NC 0.015931 2.6 I 0.001544 8 80 2 40 3 60 0 0 OPTN optineurin
596_s_at 788.4 180.48 0 1 1 0.181583 0.041776 0.042547 0.011161 4.27 Down 0.01232428 0.033075 HUMGCSFR3 Human granulocyte colony-stimulating factor receptor (CSF3R) mRNA, complete cds CSF3R 1131 M 0.043968 1005.2 A 0.066865 225.2 A 0.47938 1083 M 0.05447 497.6 A 0.339558 137.9 A 0.581931 348.9 A 0.438351 182.6 A 0.621835 81.1 A 0.824051 151.9 A 0.781055 -3.05 D 0.999351 -1.03 D 0.99943 0.9 NC 0.5 -2.31 D 0.998983 -1.27 NC 0.996037 8 80 2 40 0 0 3 60 CSF3R colony stimulating factor 3 receptor (granulocyte)
39949_at 285.8 1197.26 1 0 1 0.066597 0.02704 0.277495 0.032706 4.17 Up 0.001093448 0.005590252 Homo sapiens mRNA for MOCS1A & MOCS1B proteins, complete CDSs MOCS1 79.5 A 0.732537 559.5 A 0.189648 108.3 A 0.660442 571.9 A 0.127645 109.8 A 0.602006 738.7 A 0.07383 1260.5 P 0.039365 1001.4 A 0.138564 1654 P 0.039365 1331.7 A 0.089405 2.67 I 6.80E-05 1.31 NC 0.003962 2.32 I 0.001226 1.06 NC 0.375287 3.19 I 1.20E-05 8 80 2 40 3 60 0 0 MOCS1 molybdenum cofactor synthesis 1
40443_at 244.68 780.14 1 0 1 0.055889 0.019044 0.182 0.028678 3.26 Up 0.006370479 0.02004251 Homo sapiens p120 catenin isoform 1ABC (CTNND1) mRNA, alternatively spliced, complete cds CTNND1 341.6 A 0.438361 206.2 A 0.43834 519.7 A 0.418002 94.2 A 0.52062 61.7 A 0.561639 807.9 P 0.035163 1038.7 P 0.021866 332.9 A 0.32083 785.4 A 0.150527 935.8 A 0.07383 2.67 NC 0.018966 1.59 I 0.000463 -0.26 NC 0.194276 4.49 I 0.00205 4.72 I 0.000311 8 80 2 40 3 60 0 0 CTNND1 catenin (cadherin-associated protein), delta 1
35701_at 1051.26 397.12 0 1 1 0.241059 0.055163 0.092996 0.032136 2.59 Down 0.048976773 0.0951488 ox96d03.x1 Homo sapiens cDNA, 3 end HRAS 1045.3 A 0.11716 1300 P 0.009985 1456.2 A 0.107301 129.3 A 0.715253 1325.5 P 0.031336 690.5 A 0.234557 412.2 A 0.438361 51.9 A 0.781055 708.1 A 0.561639 122.9 A 0.94553 -0.55 NC 0.799953 -1.33 D 0.999998 -3.51 D 0.998848 2.45 NC 0.537245 -2.94 D 0.999998 8 80 2 40 0 0 3 60 HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog
37259_at 467.34 1032.42 1 0 1 0.107424 0.020122 0.240097 0.032277 2.24 Up 0.008220422 0.02443425 H.sapiens mRNA for protease inhibitor 12 (PI12; neuroserpin) SERPINI1 276.4 A 0.581931 453.1 A 0.561639 446.1 A 0.47938 365.5 A 0.250724 795.6 A 0.07383 527.4 M 0.05447 1104.2 A 0.066832 1369.1 P 0.013092 1164.1 A 0.089405 997.3 A 0.11716 0.98 I 0.002445 1.69 MI 0.002825 1.89 I 0.001304 2.18 NC 0.189741 0.59 NC 0.034854 8 80 2 40 2 40 0 0 SERPINI1 serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1
37208_at 296.24 606.04 1 0 1 0.068324 0.008233 0.14133 0.010747 2.07 Up 0.000651599 0.003796354 Homo sapiens mRNA for L-3-phosphoserine-phosphatase homologue PSPHL 198 A 0.458816 347.2 A 0.234557 276.5 A 0.5 390.6 A 0.098054 268.9 A 0.458816 490.8 M 0.043968 599.2 A 0.066865 769.3 P 0.039265 580.1 A 0.098054 590.8 A 0.073796 0.83 NC 0.019849 0.73 MI 0.002825 1.37 I 0.000763 0.79 NC 0.086123 1.07 I 0.001264 8 80 2 40 2 40 0 0 PSPH phosphoserine phosphatase
37096_at 1150.76 94.02 0 1 1 0.263164 0.050417 0.021823 0.003261 12.06 Down 0.001396211 0.006714821 Human elastase ELA2 1921.6 P 0.013092 1070.5 A 0.081337 815.9 A 0.378106 605.2 A 0.64131 1340.6 M 0.05447 47.9 A 0.939612 122.4 A 0.933135 72.8 A 0.975289 113.5 A 0.968664 113.5 A 0.882879 -4.86 D 0.999994 -2.76 D 0.999765 -3.33 D 0.997888 -2.27 NC 0.783877 -3 D 0.999946 8 80 1 20 0 0 4 80 ELA2 elastase 2, neutrophil
37829_at 757.14 193.38 0 1 1 0.174107 0.019775 0.043844 0.027462 3.97 Down 0.004882704 0.01642291 Human growth-arrest-specific protein 2 mRNA, complete cds GAS2 464.6 A 0.11716 661.6 P 0.039365 906.8 P 0.006524 850 A 0.138765 902.7 A 0.060419 17.4 A 0.995825 13.9 A 0.985118 172.9 A 0.918663 670.2 A 0.35869 92.5 A 0.882879 -4.76 D 0.999822 -5.19 D 0.999989 -2.46 D 0.99995 -0.36 NC 0.767078 -3.83 D 0.998526 8 80 1 20 0 0 4 80 GAS2 growth arrest-specific 2
34432_at 494.12 1857.12 1 0 1 0.112613 0.032761 0.433779 0.038383 3.85 Up 0.000217247 0.001813349 Homo sapiens SH3 domain containing adaptor protein (SCAP) mRNA, complete cds SH2D2A 1012.6 A 0.089405 394.8 A 0.697453 605 A 0.52062 176.7 A 0.732537 281.5 A 0.67917 1875.1 P 0.00418 2307.2 P 0.008689 1350.1 A 0.150527 1888 A 0.060419 1865.2 A 0.081337 0.93 I 4.00E-06 2.79 I 1.00E-06 1.43 I 0.002375 4.12 I 7.90E-05 3.25 I 4.00E-05 8 80 0 0 5 100 0 0 SH2D2A SH2 domain protein 2A

Total number of rows: 613

Table truncated, full table size 282 Kbytes.




Table 3: Original 793 Genes header descriptions
Probe Set ID
P Avg Signal
R Avg Signal
P<500
R<500
Sum of D2 & E2
Sensitive Mean
Sensitive SEM
Resistant Mean
Resistant SEM
Ratio
Direction
p-value
adj p-value
Gene Name
Gene ID
S Signal
S Detection
S Detection p-value
P1 Signal
P1 Detection
P1 Detection p-value
P2 Signal
P2 Detection
P2 Detection p-value
P3 Signal
P3 Detection
P3 Detection p-value
K Signal
K Detection
K Detection p-value
R1 Signal
R1 Detection
R1 Detection p-value
R2 Signal
R2 Detection
R2 Detection p-value
R3 Signal
R3 Detection
R3 Detection p-value
R4 Signal
R4 Detection
R4 Detection p-value
delta Signal
delta Detection
delta Detection p-value
R1 vs S Signal Log Ratio
R1 vs S Change
R1 vs S Change p-value
R2 vs P1 Signal Log Ratio
R2 vs P1 Change
R2 vs P1 Change p-value
R3 vs P2 Signal Log Ratio
R3 vs P2 Change
R3 vs P2 Change p-value
R4 vs P3 Signal Log Ratio
R4 vs P3 Change
R4 vs P3 Change p-value
delta vs K Signal Log Ratio
delta vs K Change
delta vs K Change p-value
Absent Count
Absent %
NC Count
NC %
Increase Count
Increase %
Decrease Count
Decrease %
Gene Symbol
Gene Title

Data table
Probe Set ID P Avg Signal R Avg Signal P<500 R<500 Sum of D2 & E2 Sensitive Mean Sensitive SEM Resistant Mean Resistant SEM Ratio Direction p-value adj p-value Gene Name Gene ID S Signal S Detection S Detection p-value P1 Signal P1 Detection P1 Detection p-value P2 Signal P2 Detection P2 Detection p-value P3 Signal P3 Detection P3 Detection p-value K Signal K Detection K Detection p-value R1 Signal R1 Detection R1 Detection p-value R2 Signal R2 Detection R2 Detection p-value R3 Signal R3 Detection R3 Detection p-value R4 Signal R4 Detection R4 Detection p-value delta Signal delta Detection delta Detection p-value R1 vs S Signal Log Ratio R1 vs S Change R1 vs S Change p-value R2 vs P1 Signal Log Ratio R2 vs P1 Change R2 vs P1 Change p-value R3 vs P2 Signal Log Ratio R3 vs P2 Change R3 vs P2 Change p-value R4 vs P3 Signal Log Ratio R4 vs P3 Change R4 vs P3 Change p-value delta vs K Signal Log Ratio delta vs K Change delta vs K Change p-value Absent Count Absent % NC Count NC % Increase Count Increase % Decrease Count Decrease % Gene Symbol Gene Title
33271_r_at 73.88 295.36 1 1 2 0.017013 0.004448 0.068316 0.009642 4.02 Up 0.001302256 0.006340747 Homo sapiens mRNA for X-like 1 protein DMXL1 88.4 A 0.541191 110.1 A 0.47938 10.6 A 0.796056 50.4 A 0.715382 109.9 A 0.561649 140.6 A 0.127645 299.5 P 0.021849 270.5 A 0.150487 364.9 A 0.458809 401.3 A 0.150527 1.12 NC 0.5 1.52 NC 0.033439 2.79 NC 0.035703 1.97 NC 0.495897 1.48 NC 0.262465 9 90 5 100 0 0 0 0 DMXL1 Dmx-like 1
39257_at 156.56 485.3 1 1 2 0.035988 0.011535 0.113049 0.009423 3.14 Up 0.000849176 0.004569906 cr24e04.x1 Homo sapiens cDNA, 3 end KLF12 145.8 A 0.581944 87.2 A 0.715382 223.7 A 0.67917 304.9 A 0.561639 21.2 A 0.910595 397.6 A 0.150527 429 A 0.175989 633.3 M 0.05447 458.2 A 0.32083 508.4 A 0.267463 0.79 NC 0.025906 1.5 NC 0.20267 1.7 NC 0.06033 0.89 NC 0.300289 3.81 NC 0.004424 9 90 5 100 0 0 0 0 KLF12 Kruppel-like factor 12
37862_at 354.74 114.18 1 1 2 0.081101 0.016096 0.027272 0.011688 2.97 Down 0.026822233 0.06142381 Human branched-chain alpha-keto acid dehydrogenase (E2) mRNA, complete cds DBT 356.6 A 0.3586 234.8 A 0.267428 588.8 A 0.138564 178.7 A 0.697453 414.8 M 0.048995 277.2 A 0.5 169.3 A 0.715285 51.9 A 0.732674 44.2 A 0.983014 28.3 A 0.978151 -0.52 NC 0.725202 -0.39 NC 0.843691 -3.3 NC 0.906304 -1.46 NC 0.55207 -2.99 NC 0.971759 9 90 5 100 0 0 0 0 DBT dihydrolipoamide branched chain transacylase (E2 component of branched chain keto acid dehydrogenase complex; maple syrup urine disease)
34414_at 147.28 415.98 1 1 2 0.033845 0.010474 0.096487 0.022989 2.85 Up 0.038132464 0.0799804 Human mRNA for KIAA0368 gene, partial cds KIAA0368 282.1 A 0.234557 207.5 A 0.35869 67 A 0.902095 151.7 A 0.660468 28.1 A 0.97214 302.8 M 0.05447 170.8 A 0.52064 718.1 P 0.019271 574 A 0.358668 314.2 A 0.418069 0.3 NC 0.64579 -0.41 NC 0.5 1.84 NC 0.062599 1.4 NC 0.044415 2.09 NC 0.268596 8 80 5 100 0 0 0 0 KIAA0368 KIAA0368
34844_at 458.7 161.44 1 1 2 0.105459 0.015437 0.037466 0.013866 2.81 Down 0.011242282 0.03079387 Human mRNA for KIAA0222 gene, complete cds ZNF516 542.5 P 0.014937 414.5 A 0.218945 265.1 A 0.418069 658.6 A 0.284747 412.8 A 0.250724 295.1 A 0.458816 26.4 A 0.892776 76 A 0.64131 95 A 0.872355 314.7 A 0.479377 -1.27 NC 0.994204 -2.64 NC 0.941875 -1.51 NC 0.815287 -2.47 NC 0.99122 -0.37 NC 0.755488 9 90 5 100 0 0 0 0 ZNF516 zinc finger protein 516
32781_f_at 163.54 441.84 1 1 2 0.037738 0.012081 0.102502 0.019865 2.72 Up 0.02372198 0.05576029 zk65d06.r1 Homo sapiens cDNA, 5 end DST 81 A 0.859735 180.4 A 0.733935 22.3 A 0.944152 209.1 A 0.140265 324.9 A 0.197123 453.2 P 0.015454 219.3 A 0.153263 519.1 A 0.153312 290.9 A 0.213217 726.7 M 0.04977 2.44 NC 0.035952 0.55 NC 0.07643 3.88 NC 0.191017 0.43 NC 0.5 0.94 NC 0.044859 8 80 5 100 0 0 0 0 BPAG1 bullous pemphigoid antigen 1, 230/240kDa
33803_at 149.6 361.98 1 1 2 0.034337 0.004917 0.085285 0.019037 2.48 Up 0.032053315 0.07053976 Human thrombomodulin gene, complete cds - 215.6 A 0.64131 173.4 A 0.892699 89.4 A 0.94553 117.8 A 0.939581 151.8 A 0.92617 325 A 0.52062 533.5 A 0.234557 526.3 P 0.008689 113.6 A 0.795978 311.5 A 0.250724 0.7 NC 0.112101 1.84 NC 0.011831 3.09 NC 0.01242 0.18 NC 0.403969 1.48 NC 0.034854 9 90 5 100 0 0 0 0 THBD thrombomodulin
32570_at 199.08 471.92 1 1 2 0.0455 0.015478 0.109623 0.013277 2.41 Up 0.013714306 0.03614144 Homo sapiens NAD+-dependent 15 hydroxyprostaglandin dehydrogenase (PGDH) mRNA, complete cds HPGD 335.1 A 0.218945 37.1 A 0.541191 37.3 A 0.972222 335.9 A 0.35869 250 A 0.458816 356.5 A 0.098054 497.3 A 0.081337 408 P 0.039365 396 A 0.339558 701.8 P 0.021866 0.3 NC 0.062599 3.45 NC 0.074959 3.3 NC 0.025906 -0.01 NC 0.058125 1.44 NC 0.010207 8 80 5 100 0 0 0 0 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
38844_at 185.02 439.84 1 1 2 0.042977 0.014481 0.102982 0.016738 2.4 Up 0.026612017 0.06121662 Homo sapiens pyruvate dehydrogenase kinase isoenzyme 2 (PDK2) mRNA, complete cds PDK2 114.8 A 0.781055 331.8 A 0.378184 56.6 A 0.882996 333.7 A 0.458816 88.2 A 0.861235 565.2 P 0.02786 538 M 0.054441 245.9 A 0.541184 550.4 A 0.418069 299.7 A 0.438361 2.22 NC 0.013675 0.47 NC 0.042689 1.95 NC 0.200047 0.96 NC 0.293817 2.12 NC 0.034854 8 80 5 100 0 0 0 0 PDK2 pyruvate dehydrogenase kinase, isoenzyme 2
33541_s_at 466.18 203.1 1 1 2 0.107204 0.00451 0.046848 0.02195 2.29 Down 0.02735058 0.06221572 zl17h10.r1 Homo sapiens cDNA, 5 end LAIR2 410.8 P 0.039365 467.4 P 0.007543 468.9 A 0.302547 515.5 P 0.003067 468.3 A 0.07383 189.4 A 0.35869 160.6 A 0.541184 42 A 0.765481 578.2 A 0.267463 45.3 A 0.861235 -1.3 NC 0.986325 -1.44 NC 0.971759 -2.39 NC 0.485084 0.23 NC 0.901514 -2.58 NC 0.993558 7 70 5 100 0 0 0 0 LAIR2 leukocyte-associated Ig-like receptor 2
1249_at 179.3 393.9 1 1 2 0.040946 0.01411 0.092012 0.006217 2.25 Up 0.010666449 0.02959686 HSU43885 Human Grb2-associated binder-1 mRNA, complete cds GAB1 386.6 A 0.089405 202.3 A 0.378165 211.7 A 0.660468 59.9 A 0.795978 36 A 0.824051 414.5 A 0.218983 382.9 A 0.204022 430.2 M 0.043968 302.8 A 0.47938 439.1 A 0.073796 -0.21 NC 0.5 0.42 NC 0.28107 1.05 NC 0.205324 1.58 NC 0.300289 3.02 NC 0.09528 9 90 5 100 0 0 0 0 GAB1 GRB2-associated binding protein 1
31418_at 498.68 226.12 1 1 2 0.114424 0.021274 0.053283 0.012162 2.15 Down 0.037226902 0.07856451 Human DNA sequence from PAC 388M5 on chromosome 22. Contains a 60S Ribosomal protein L1 like pseudogene, a chromosomal protein HMG-17 like gene, a Sulfotransferase (Sulfokinase) like gene, a putative GS2 like gene, a predicted CpG island, ESTs and ST - 427.7 A 0.11716 376.7 A 0.189687 837.2 P 0.017001 551.5 P 0.021866 300.3 A 0.189687 189.2 A 0.07383 368.8 P 0.005636 298.6 A 0.284747 81.2 A 0.35869 192.8 A 0.302547 0.04 NC 0.5 0.11 NC 0.5 -1.3 NC 0.966561 -1.72 NC 0.829869 -0.53 NC 0.411228 7 70 5 100 0 0 0 0 HMGN2 high-mobility group nucleosomal binding domain 2
36435_at 399.32 191.58 1 1 2 0.091655 0.008101 0.044988 0.006344 2.04 Down 0.00191025 0.008400991 Homo sapiens protein phosphatase 2C alpha 2 mRNA, complete cds PPM1A 460 P 0.008689 315.6 A 0.073695 323.7 A 0.267428 496.4 P 0.005636 400.9 A 0.073796 180.5 A 0.284715 264.1 A 0.117121 226 A 0.234519 120.2 A 0.781017 167.1 A 0.320802 -1.14 NC 0.980188 -0.16 NC 0.350735 -0.58 NC 0.433177 -1.75 NC 0.996649 -0.94 NC 0.799953 8 80 5 100 0 0 0 0 PPM1A protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
41815_at 54.64 451.94 1 1 2 0.01241 0.005461 0.104686 0.019278 8.44 Up 0.001743058 0.007851439 Homo sapiens mRNA; cDNA DKFZp434G173 (from clone DKFZp434G173) SYNE2 94 A 0.795978 16.9 A 0.960635 130.5 A 0.872394 17.2 A 0.983014 14.6 A 0.999044 222.9 A 0.581931 554.5 M 0.048939 324.9 A 0.302547 438.3 A 0.397994 719.1 P 0.035163 0.63 NC 0.306825 4.74 NC 0.006442 1.36 NC 0.127011 4.09 NC 0.007968 4.67 I 6.00E-06 8 80 4 80 1 20 0 0 SYNE2 spectrin repeat containing, nuclear envelope 2
34940_at 28.46 218.22 1 1 2 0.006557 0.000685 0.050981 0.016175 7.78 Up 0.025289464 0.0585696 Homo sapiens mRNA; cDNA DKFZp564O0862 (from clone DKFZp564O0862) - 19.5 A 0.972161 30 A 0.697483 25.4 A 0.926305 36 A 0.732572 31.4 A 0.872355 150.9 A 0.320774 174.3 A 0.520623 428.2 P 0.013092 23.4 A 0.918734 314.3 A 0.138765 2.9 NC 0.012119 2.43 NC 0.119392 4.05 I 0.001876 1.17 NC 0.375287 3.27 NC 0.006111 9 90 4 80 1 20 0 0 --- MRNA; cDNA DKFZp564O0862 (from clone DKFZp564O0862)
36550_at 66.68 375.64 1 1 2 0.015288 0.009566 0.086525 0.024724 5.66 Up 0.027616788 0.06268183 Human DNA sequence from clone 1175I6 on chromosome 20. Contains the gene for Ras inhibitor JC265 (Ras association (RalGDS - 15 A 0.998651 39.3 A 0.933135 19.3 A 0.972161 26 A 0.975289 233.8 A 0.697573 458.7 A 0.060419 66.6 A 0.621835 236.3 A 0.458816 392.2 A 0.284747 724.4 P 0.009985 4.98 I 0.000408 1.21 NC 0.182225 2.77 NC 0.06033 3.65 NC 0.019849 1.09 NC 0.005494 9 90 4 80 1 20 0 0 RIN2 Ras and Rab interactor 2
34706_at 452.42 100.04 1 1 2 0.103883 0.025868 0.023304 0.009555 4.46 Down 0.019229265 0.04709443 Homo sapiens mRNA for KIAA0518 protein, partial cds MGA 465.9 A 0.250724 212.6 A 0.284747 212.8 A 0.732537 798.7 P 0.003585 572.1 A 0.107301 19.4 A 0.901946 70.7 A 0.849473 255.7 A 0.302547 86.9 A 0.872355 67.5 A 0.92617 -4.45 NC 0.951964 -0.92 NC 0.843691 0.78 NC 0.5 -2.92 D 0.999104 -2.72 NC 0.99122 9 90 4 80 0 0 1 20 MGA MAX gene associated
31824_at 268.98 63.26 1 1 2 0.062035 0.013366 0.014314 0.010576 4.33 Down 0.023205696 0.05479867 dJ747H23.1 (malic enzyme 1, soluble (NADP-dependent malic enzyme, malate oxidoreductase, EC 1.1.1.40)) - 140.6 A 0.795978 368.4 A 0.11716 189.3 A 0.978151 207.4 A 0.378184 439.2 P 0.014937 7.2 A 0.999735 11.9 A 0.995137 29.2 A 0.901983 251.9 A 0.824011 16.1 A 0.861235 -4.22 MD 0.997094 -4 NC 0.994793 -1.91 NC 0.631784 0.56 NC 0.731404 -4.14 NC 0.994873 9 90 4 80 0 0 0 0 ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
31441_at 310.74 75.92 1 1 2 0.070696 0.022799 0.017593 0.002466 4.02 Down 0.049247978 0.09546172 Human ECRP gene for eosinophil cationic related protein - 606.2 M 0.043968 71 A 0.901946 468.1 A 0.581931 293.5 A 0.697453 114.9 A 0.892699 44.7 A 0.985063 67.7 A 0.964837 84 A 0.964837 114.3 A 0.968664 68.9 A 0.983 -3.45 D 0.999885 0.09 NC 0.71893 -2.32 NC 0.950067 -1.4 NC 0.731404 0.53 NC 0.5 9 90 4 80 0 0 1 20 RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
1088_at 489.42 128.74 1 1 2 0.111954 0.017593 0.029924 0.00884 3.74 Down 0.003137977 0.0120397 HUMBDNFB Human brain-derived neurotrophic factor (BDNF) mRNA, complete cds BDNF 704.1 P 0.000803 289.8 A 0.098054 335.9 A 0.47938 491.6 P 0.003585 625.7 P 0.005643 25.4 A 0.824011 149.7 A 0.64131 212.3 A 0.520633 53.7 A 0.978151 202.6 A 0.641332 -4.84 D 0.999501 -1.11 NC 0.966561 -1.09 NC 0.860937 -3.03 NC 0.988169 -1.58 NC 0.994793 7 70 4 80 0 0 1 20 BDNF brain-derived neurotrophic factor

Total number of rows: 793

Table truncated, full table size 365 Kbytes.




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Series Matrix File(s) TXTHelp

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GSE7114_RAW.tar 12.8 Mb (http)(custom) TAR (of CEL)

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