GEO DataSets

Analysis of hearts of animals after subchronic exposure to zinc via nose only inhalation of aerosolized zinc sulfate (10, 30 or 100 ug zinc/m3), for 5 hours/day, 3 days/week for 16 weeks. Results provide insight into the effect of inhalation of zinc at environmentally relevant levels on the heart.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 4 dose sets

Platform:

GPL341

Series:

GSE11091

24 Samples

Download data: CEL, CHP

(Submitter supplied) Zinc is a common metal in most ambient particulate matter (PM), and has been proposed to be a causative component in PM-induced adverse cardiovascular health effects. Zinc is also an essential metal and has the potential to induce many physiological and nonphysiological changes. Most toxicological studies employ high levels of zinc. We hypothesized that subchronic inhalation of environmentally relevant levels of zinc would cause cardiac changes in healthy rats. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3369

Platform:

GPL341

24 Samples

Download data: CEL, CHP

(Submitter supplied) Zinc (Zn) is a major elemental component of respirable ambient particulate matter (PM) detected often at alarming levels in urban air. Exposure to PM has been widely associated with increased cardiovascular morbidity and mortality, however, it is not known what components or sources of PM are causative. We recently demonstrated that long-term episodic inhalation of combustion PM, having similar amount of Zn found in urban PM, caused myocardial lesions in rats. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

24 Samples

Download data: CEL

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) Carbonyl chloride (phosgene) is a toxic industrial compound (TIC) widely used in industry for the production of synthetic products, such as polyfoam rubber, plastics, and dyes. Exposure to phosgene results in a latent (1-24 hr), potentially life-threatening pulmonary edema and irreversible acute lung injury. A genomic approach was utilized to investigate the molecular mechanism of phosgene-induced lung injury. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1244

Platform:

GPL339

104 Samples

Download data: CEL, CHP, EXP, RPT

Analysis of lungs exposed to the toxic industrial compound carbonyl chloride (phosgene). Phosgene exposure results in pulmonary edema and acute lung injury. Lungs examined at several time points up to 72 hours after exposure. Provides insight into molecular events affected in phosgene-injured lungs.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 agent, 9 time sets

Platform:

GPL339

Series:

GSE2565

104 Samples

Download data: CEL, CHP, EXP, RPT

(Submitter supplied) DEP exposure is linked to increases in cardiovascular effects. This effect is enhanced in individuals with pre-existing disease. Animal models of cardiovascular disease are used to study this susceptibility. The heart is rich in mitochondria, which produce high levels of free radicals, leading to inactivation of tricarboxylic acid cycle enzymes. We hypothesized that a 4-wk DEP inhalation would result in strain-related structural impairment of cardiac mitochondria and changes in these enzyme activities in WKY and SHR. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3689

Platform:

GPL341

16 Samples

Download data: CEL, CHP

Analysis of heart left ventricle from healthy animals exposed to diesel exhaust (DE) particles. Spontaneously hypertensive animals also examined. DE is linked to cardiovascular impairment. Results suggest DE exposure produces a hypertensive-like cardiac gene expression pattern in healthy animals.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state, 2 stress sets

Platform:

GPL341

Series:

GSE9694

16 Samples

Download data: CEL, CHP