GEO DataSets

Analysis of multiple myeloma MM1.S cells depleted for beta-catenin. Beta-catenin is an effector of the Wnt signaling pathway. Results provide insight into the role of Wnt/beta-catenin signaling in the progression of multiple myeloma.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 protocol sets

Platform:

GPL570

Series:

GSE17385

6 Samples

Download data: CEL

(Submitter supplied) MM1.S cells stably transduced with control or b-catenin shRNA were established. Total RNA was isolated from 5x 10^6 cells of each in triplicate.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3578

Platform:

GPL570

6 Samples

Download data: CEL

(Submitter supplied) Samples in this series are pre-treatment bone marrow aspirates from multiple myeloma patients Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

65 Samples

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(Submitter supplied) Activation of the canonical Wnt signaling pathway is commonly observed in pancreatic cancer. We therefore sought to identify a gene expression profile associated with the activation of this pathway in pancreatic cancer cells. We used microarrays to identify differentially expressed genes upon expression of an activated form of beta-catenin or its negative regulator ICAT (beta-catenin-interacting protein 1).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

9 Samples

Download data: CEL

(Submitter supplied) Multiple Myeloma is universally preceded by a pre-malignant state, however, the genetic and immune mechanisms associated with transformation are incompletely understood thus hindering development of preventative treatment strategies. Using single-cell RNA sequencing, we profiled the transcriptomes of tumor and immune microenvironment cells derived from transgenic mice whose disease spanned the myeloma progression spectrum. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

18 Samples

Download data: FA, TXT