GEO DataSets

Analysis of malignant mesothelioma (MM) cell lines (M25, M29, and M49) exposed to Onconase for 24 hrs. Onconase, an RNA damaging therapeutic agent, induces apoptosis in MM cells. Results provide insight into the molecular mechanisms underlying Onconase action in MM.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 cell line sets

Platform:

GPL570

Series:

GSE17009

6 Samples

Download data: CEL, CHP

(Submitter supplied) Onconase represents a new class of RNA-damaging drugs. Mechanistically, Onconase is thought to internalize, where it degrades intracellular RNAs such as tRNA and double-stranded RNA, and thereby suppresses protein synthesis. However, there may be additional or alternative mechanism(s) of action. Microarray analysis was used to compare gene expression profiles in untreated human malignant mesothelioma (MM) cell lines and cells exposed to 5 ug/ml Onconase for 24 h.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3759

Platform:

GPL570

6 Samples

Download data: CEL, CHP

(Submitter supplied) PE5 is a nuclear-directed human ribonuclease variant that exhibits selective cytotoxicity against cancer cells. Onconase is a natural cytotoxic ribonuclease that has reached advanced clinical trials for the treatment of different types of cancer. Onconase also posses established antiviral effects. In the present work, we have used global gene expression microarrays to study the effects caused by PE5 and onconase, and therefore elucidate the mechanism by which these ribonucleases induce cytotoxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13607

12 Samples

Download data: PDF, TXT, XLSX

(Submitter supplied) Diffuse malignant peritoneal mesothelioma (DMPM) is a rapidly lethal malignancy. The comprehension of the molecular features of DMPM is of utmost importance for the fruitful management of the disease, especially in patients who fail standard treatments and have a poor prognosis due to the lack of effective alternative therapeutic options.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

50 Samples

Download data: TXT

(Submitter supplied) To investigate the molecular events controlling malignant transformation of human pleural cells, we compared constitutive gene expression of mesothelioma cells to that of pleural cells. Using cDNA microarray and high-density filter array, we assessed expression levels of > 6500 genes. Most of the highly expressed transcripts were common to both cell lines and included genes associated with stress response and DNA repair, outcomes consistent with the radio- and chemo-resistance of mesothelioma. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3377

1 Sample

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(Submitter supplied) spotted cDNA amplified by PCR on an array containing 6356 probes with sequence complementary to 4311 human genes and 2045 human ESTs

Organism:

Homo sapiens

1 Series

1 Sample

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