GEO DataSets

Analysis of gracilis and semitendinosus muscle biopsies from pediatric cerebral palsy (CP) patients. Muscles from CP patients are spastic and form contractures limiting range of motion and joint function. Results provide insight into molecular basis of skeletal muscle response to CP.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 2 tissue sets

Platform:

GPL571

Series:

GSE31243

40 Samples

Download data: CEL

(Submitter supplied) Cerebral palsy is primarily an upper motor neuron disease that results in a spectrum of progressive movement disorders. Secondary to the neurological lesion, muscles from patients with cerebral palsy are often spastic and form debilitating contractures that limit range of motion and joint function. With no genetic component, the pathology of skeletal muscle in cerebral palsy is a response to aberrant neurological input in ways that are not fully understood. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4353

Platform:

GPL571

40 Samples

Download data: CEL, TXT

(Submitter supplied) Cerebral palsy is caused be an upper motor neuron lesion which casues spasticity as well as secondary effects on muscle . Muscle from cerebral palsy patients is has been shown to be smaller, with more ECM and longer sarcomere lengths We used microarrays to globally investigate the transcriptional adaptations of cerebral palsy muscle and research which muscle pathways are altered in the diseased state Keywords: Disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3644

Platform:

GPL96

16 Samples

Download data: CEL, CHP, TXT

Analysis of wrist muscle extensors and flexors of cerebral palsy (CP) patients. CP is an upper motor neuron disease that results in a progressive movement disorder. Muscles of CP patients often become spastic. Results provide insight into the molecular alterations in spastic muscles of CP patients.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 8 individual, 2 tissue sets

Platform:

GPL96

Series:

GSE11686

16 Samples

Download data: CEL, CHP