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| Status |
Public on Aug 26, 2009 |
| Title |
Unique Transcriptional Profile in Wrist Muscles From Cerebral Palsy Patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Cerebral palsy is caused be an upper motor neuron lesion which casues spasticity as well as secondary effects on muscle . Muscle from cerebral palsy patients is has been shown to be smaller, with more ECM and longer sarcomere lengths
We used microarrays to globally investigate the transcriptional adaptations of cerebral palsy muscle and research which muscle pathways are altered in the diseased state
Keywords: Disease state analysis
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| Overall design |
Muscle biopsies were taken from children undergoing surgery which exposed wrist muscle extensors (n=8) and flexors (n=8) in both cerebral palsy patients (n=6) and control patients (n=2) for RNA extraction and hybridization to Affymetrix GeneChips . Cerebral palsy patients were classified by a number of clinical scores.
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| Contributor(s) |
Smith LR, Pontén E, Ward SR, Chambers H, Subramaniam S, Lieber RL |
| Citation(s) |
19602279 |
| |
| Submission date |
Jun 04, 2008 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Lucas Robert Smith |
| E-mail(s) |
lrs001@ucsd.edu
|
| Organization name |
University of California San Diego
|
| Department |
Bioengineering
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| Lab |
Muscle Physiology Laboratory
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| Street address |
3350 La Jolla Village Drive Mail Code 151
|
| City |
San Diego |
| State/province |
CA |
| ZIP/Postal code |
92161 |
| Country |
USA |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA106091 |
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