GEO DataSets

Analysis of non-lesional (NL) skin of psoriasis patients 24 hrs after a single intradermal injection of interferon-γ (IFN-γ) to the NL skin. Results suggest that IFN-γ may prime an inflammatory environment in the skin that shares many features with psoriasis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 20 individual, 3 protocol, 2 time sets

Platform:

GPL571

Series:

GSE32407

60 Samples

Download data: CEL

(Submitter supplied) Psoriasis is a chronic, debilitating, immune-mediated inflammatory skin disease. As IFN-γ is involved in many cellular processes, including activation of T cells and dendritic cells (DCs), antigen processing and presentation, cell adhesion and trafficking, and cytokine and chemokine production, IFN-γ-producing Th1 cells were proposed to be integral to the pathogenesis of psoriasis. Recently, IFN-γ was shown to enhance IL-23 and IL-1 production by DCs and subsequently induce Th17 cells, important contributors to the inflammatory cascade in psoriasis lesions. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4607

Platform:

GPL571

60 Samples

Download data: CEL

(Submitter supplied) Background: Previous work has identified CD11c+CD1c- dendritic cells (DCs) as the major ”inflammatory” dermal DC population in psoriasis vulgaris and CD1c+ DCs as the “resident” cutaneous DC population. Objective: To further define molecular differences between these two myeloid dermal DC populations. Methods: Inflammatory and resident DCs were single-cell sorted from psoriasis lesional skin biopsies, and gene array expression profiling was performed. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

7 Samples

Download data: CEL

(Submitter supplied) We observed robust overexpression of type I interferon (IFN)–inducible genes and genomic signatures that indicate T cell and dendritic cell infiltration in lesional skin. Up-regulation of mRNAs for IFN-a subtypes was observed in lesional skin compared with nonlesional skin. Enrichment of mature dendritic cells and 2 type I IFN–inducible proteins, STAT1 and ISG15, were observed in the majority of lesional skin biopsies. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3539

Platform:

GPL570

82 Samples

Download data: CEL

Analysis of lesional and non-lesional skins from patients with psoriasis. Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiation, surface scale formation, and marked cutaneous inflammation. Results provide insight into the molecular pathogenesis of psoriasis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 54 individual, 3 specimen sets

Platform:

GPL570

Series:

GSE14905

82 Samples

Download data: CEL

(Submitter supplied) In this study, we shought to identify the cytokines produced by skin-resident T cells in normal skin, localize the receptors for these cytokines, and examine how these cytokines alter gene expression profiles of the cells bearing cognate receptors. Keywords: repeated measures experiment

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

12 Samples

Download data: CEL

(Submitter supplied) Scalp psoriasis shows a variable clinical spectrum and in many cases poses a great therapeutic challenge. However, it remains unknown whether the immune response of scalp psoriasis differs from understood pathomechanisms of psoriasis on other skin areas. We sought to determine the cellular and mollecular phenotype of scalp psoriasis by performing a comparative analysis of scalp vs skin using lesional and nonlesional samples from 20 Caucasian subjects with untreated moderate to severe psoriasis and significant scalp involvement, and 10 control subjects without psoriasis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

45 Samples

Download data: CEL

(Submitter supplied) To understand the development of new psoriasis lesions, we studied a group of moderate-to-severe psoriasis patients who experienced a relapse after ceasing efalizumab (anti-CD11a, Raptiva, Genentech). There were increased CD3+ T cells, neutrophils, CD11c+ and CD83+ myeloid DCs, but no increase in CD1c+ resident myeloid DCs. In relapsed lesions, there were many CD11c+CD1c-, inflammatory myeloid DCs identified by TNFSF10/TRAIL, TNF, and iNOS. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4606

Platform:

GPL571

14 Samples

Download data: CEL

Analysis of skin samples from 4 responding patients who relapsed following efalizumab treatment for psoriasis: baseline non-lesional and lesional samples; week 12 post-treatment and relapse samples. Results provide insight into molecular mechanisms underlying post-therapeutic relapse of psoriasis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 disease state, 4 individual, 2 time sets

Platform:

GPL571

Series:

GSE30768

14 Samples

Download data: CEL

(Submitter supplied) In this study, our aim was to investigate the potential inflammatory pathways underlining PV, PPPP, and NPPP, through histologic and immunohistochemical characterization of the inflammation and gene expression profiling in skin samples of participants with PPPP, NPPP, PV (without palmo-plantar involvement), and healthy controls.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

88 Samples

Download data: CSV

(Submitter supplied) Skin and blood single cell RNA sequencing datasets of IL-22- and IFNγ-secreting CD1a-reactive GAS-responsive T cells were generated from four healthy skins, five healthy PBMCs and three psoriatic PBMCs. Using cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq), we measured T cell specific functional states at both protein and transcriptome levels.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL24676

18 Samples

Download data: TXT

(Submitter supplied) MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as central regulators of gene expression and powerful biomarkers of disease. Much is yet unknown about their role in psoriasis pathology. To globally characterize the miRNAome of psoriatic skin, skin biopsies were collected from psoriatic cases (n = 75) and non-psoriatic controls (n = 57) and RNA sequenced. Count data was meta-analyzed with a previously published dataset (cases, n = 24, controls, n = 20), increasing the number of psoriatic cases four-fold from previously published studies. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL20301

192 Samples

Download data: TXT

(Submitter supplied) We compared the PSM lesional/non-lesional skin samples with the control skin in the analysis.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

7 Samples

Download data: MTX, TSV

(Submitter supplied) The skin is recognized as a window into the immunopathogenic mechanisms driving the vast phenotypic spectrum of psoriatic disease. To better decipher the cellular landscape of both healthy and psoriatic skin, we employed spatial transcriptomics (ST), a ground-breaking technology that precisely maps gene expression from histologically-intact tissue sections. Findings gleaned from computationally integrating our 23 matched lesional and non-lesional psoriatic and 7 healthy control samples with publicly-available single cell RNA seq data sets provided insights into the emergent cellular ecosystems at play in psoriatic disease.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

30 Samples

Download data: H5