GEO DataSets

Analysis of HeLa epithelial cells stably-transfected with a SteA-3xFLAG fusion construct. Salmonella effector SteA is a substrate for both type III secretion systems which are essential for virulence. Results provide insight into the role of SteA during infections.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 cell line, 2 protocol sets

Platform:

GPL6244

Series:

GSE51043

9 Samples

Download data: CEL

(Submitter supplied) Salmonella enterica is a Gram-negative bacterium that causes gastroenteritis, bacteremia and typhoid fever in several animal species including humans. Its virulence is greatly dependent on two type III secretion systems (T3SSs), encoded in pathogenicity islands 1 (SPI1) and 2 (SPI2), respectively. These systems translocate proteins called effectors into eukaryotic host cell. Effectors interfere with certain host signal transduction pathways to allow the internalization of pathogens and their survival and proliferation inside vacuoles. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5097

Platform:

GPL6244

9 Samples

Download data: CEL

(Submitter supplied) SrfJ is an effector of the type III secretion systems of the Gram-negative intracellular pathogen Salmonella enterica serovar Typhimurium. To study the effects of this effector on global gene expression in host cells, we have infected murine RAW264.7 macrophages with two strains of Salmonella enterica serovar Typhimurium. The comparison between cells infected with the wild-type strain and cells infected with a srfJ mutant revealed a number of genes that are differentially expressed when SrfJ is present.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23038

6 Samples

Download data: CEL, CHP

(Submitter supplied) SrfJ is an effector of the type III secretion systems of the Gram-negative intracellular pathogen Salmonella enterica serovar Typhimurium. To study the effects of this effector on global gene expression in host cells, we have expressed SrfJ on human HeLa cells through transient transfection. The comparison with HeLa cells transfected with a plasmid not expressing SrfJ, revealed a number of genes that are differentially expressed when SrfJ is present.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23159

6 Samples

Download data: CEL, CHP

(Submitter supplied) The aim of this work was to study the cellular gene expression profiles associated with the entry mechanism of Salmonella typhimurium. Whatever the bacterial strain used for infection, the expression of numerous genes associated with the extracellular matrix was modified.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL22145

23 Samples

Download data: TXT