GEO DataSets

Transcriptional profile of normal skeletal muscle collected at autopsy compared to surgical specimens.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 specimen sets

Platform:

GPL8300

Series:

GSE595

14 Samples

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(Submitter supplied) Standard Affymetrix procedure, RNA from frozen tissue Keywords: equivalent probe

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS511

Platform:

GPL8300

14 Samples

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(Submitter supplied) Background: Insulin's effect on protein synthesis (translation of transcripts) and post-translational modifications, especially those involving reversible modifications such as phosphorylation of various signaling proteins, are extensively studied. On the other hand, insulin's effect on the transcription of genes, especially of transcriptional temporal patterns, is not well investigated in the literature. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

53 Samples

Download data: CEL

(Submitter supplied) Insulin action in target tissues involved precise regulation of gene expression. To define the set of insulin-regulated genes in human skeletal muscle, we analyzed the global changes in mRNA levels during a 3-h hyperinsulinemic euglycemic clamp in vastus lateralis muscle of six healthy subjects. Using 29,308 cDNA element microarrays, we found that the mRNA expression of 762 genes, including 353 expressed sequence tags, was significantly modified during insulin infusion. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3271

6 Samples

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(Submitter supplied) The aim of this project is to identify distinct temporal patterns of RNA expression in the skeletal muscle of rats following a bolus dose of the corticosteroid methylprednisolone. 51 RG_U34A chips were used over 17 time points. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS256

Platform:

GPL85

51 Samples

Download data: CEL

Temporal analysis of skeletal muscle response to corticosteroid methylprednisolone. Wistar rats injected with methylprednisolone and skeletal muscle analyzed at various time points up to 72 hours.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 17 time sets

Platform:

GPL85

Series:

GSE490

51 Samples

Download data: CEL

(Submitter supplied) Attempts to establish a tissue bank from autopsy samples have led to uncovering of the secrets of many diseases. Here, we examined the length of time that the RNA from postmortem tissues is available for microarray analysis and reported the gene expression profile for up- and down-regulated genes during the postmortem interval (PMI). We extracted RNA from fresh-frozen (FF) and formalin-fixed paraffin-embedded (FFPE) brains and livers of three different groups of mice: 1) mice immediately after death, 2) mice that were stored at room temperature for 3 h after death, and 3) mice that were stored at 4°C for 18 h after death, as this storage resembles the human autopsy process in Japan. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11180

12 Samples

Download data: CEL

(Submitter supplied) vastus lateralis biopsies were obtained from healthy subjects, either young adults (20-29 yr old) or older (65-75 yr old) Keywords = muscle Keywords = aging Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS287 GDS288

Platforms:

GPL96 GPL97

30 Samples

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Comparison of gene expression in vastus lateralis skeletal muscle biopsies in healthy young (21-27 year old) and older (67-75 year old) men.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL97

Series:

GSE362

15 Samples

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Comparison of gene expression in vastus lateralis skeletal muscle biopsies in healthy young (21-27 year old) and older (67-75 year old) men

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL96

Series:

GSE362

15 Samples

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(Submitter supplied) To identify biological processes as well as molecular markers for drip loss, the transcriptomes of logissimus dorsi from 6 sib pair of F2 animals Keywords: T-test paired and SAM

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

12 Samples

Download data: CEL

(Submitter supplied) Comparison of normal adult rat extraocular muscle, cardiac muscle, leg (gastrocnemius-soleus) muscle and smooth muscle (stomach wall). Affymetrix microarray chip RG-U34A was used. MAS version 5 was used to analyze the muscle group differences. Data form part of publication: FASEB Journal 17: 1370-1372, 2003 (full length article available at http://www.fasebj.org/cgi/doi/10.1096/fj.02-1108fje). Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS276

Platform:

GPL85

14 Samples

Download data: CEL

Examination of control adult rat extraocular muscle, cardiac muscle, leg gastroc-soleus muscle and smooth muscle from stomach wall.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 tissue sets

Platform:

GPL85

Series:

GSE142

14 Samples

Download data: CEL

(Submitter supplied) To further understand molecular mechanisms underlying skeletal muscle hypertrophy, expression profiles of translationally and transcriptionally regulated genes were characterized following an acute bout of maximally activated eccentric contractions. Experiments demonstrated that translational mechanisms contribute to acute gene expression changes following high resistance contractions with two candidate mRNAs, basic fibroblast growth factor (bFGF) and elongation factor-1 alpha (EF1alpha), targeted to the heavier polysomal fractions after a bout of contractions. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS278

Platform:

GPL85

36 Samples

Download data: CEL

Trancriptionally and translationally-regulated gene expression underlying skeletal muscle hypertrophy induced by acute maximally activated eccentric contractions. Total RNA or polysomal RNA examined at one and six hours post contraction.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol, 2 specimen, 3 time sets

Platform:

GPL85

Series:

GSE467

36 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL9454 GPL570

65 Samples

Download data: CEL

(Submitter supplied) Disuse atrophy is a common clinical phenomenon which significantly impacts muscle function and activities of daily living. In this study, we did expression profiling to identify transcriptional pathways associated with muscle remodeling in a clinical model of disuse. Keywords: Differentiation design

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL91 GPL8300

28 Samples

Download data: CEL

(Submitter supplied) Exercise attenuates the development of chronic non-communicable diseases (NCDs). Gene signaling pathway analysis offers an opportunity to discover if electrically induced muscle exercise regulates key pathways among people living with spinal cord injury (SCI). We examined short-term and long-term durations of electrically induced skeletal muscle exercise on complex gene signaling pathways, specific gene regulation, and epigenetic tagging of PGC1a, a major transcription factor in skeletal muscle of men with SCI. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

30 Samples

Download data: CEL

(Submitter supplied) Common acute injuries to skeletal muscle can lead to significant pain and disability. The current therapeutic approaches for treating muscle injuries are dependent on the clinical severity but not on the type of injury. The aim of this study was to compare the molecular events accompanying the degeneration and repair phases of contraction- and trauma-induced muscle injuries by applying DNA microarray methodology to two well-characterized mouse models of skeletal muscle injury, i.e., eccentric contraction-induced injury (CI) and traumatic injury induced by freezing (FI). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2701

Platform:

GPL81

25 Samples

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Analysis of skeletal muscles at various time points up to 7 days following injury caused by eccentric contraction (CI) or by freezing (FI). Results provide insight into the molecular events accompanying the degeneration and repair phases of contraction- and trauma-induced muscle injuries.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol, 5 time sets

Platform:

GPL81

Series:

GSE5413

25 Samples

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