GEO DataSets

Temporal analysis of diaphram muscle from dystrophin-deficient mdx mice, a Duchenne muscular dystrophy (DMD) model. Postnatal ages 7 to 112 days examined. Results provide insight into mechanisms of muscular dystrophy pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 6 age, 2 strain sets

Platform:

GPL81

Series:

GSE1026

36 Samples

Download data: CEL

(Submitter supplied) Determination of gene expression changes in extraocular muscle of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112 days. 3 independent replicates/age/strain. Data form part of publication: Human Molecular Genetics 13:257-269, 2004. Keywords = microarray Keywords = muscle Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS638

Platform:

GPL81

36 Samples

Download data: CEL

(Submitter supplied) Laminin (merosin) deficient muscular dystrophy in dy/dy mouse diaphragm muscle, 8 weeks old Keywords: muscle, muscular dystrophy, laminin, merosin, diaphragm, mouse

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1778

Platform:

GPL339

8 Samples

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Analysis of diaphragms of alpha2-laminin deficient dy/dy animals. Alpha-2 laminin is important in muscle cell attachment, and its deficiency underlies classical congenital muscular dystrophy. Results provide insight into the events that link alpha2-laminin deficiency with muscle fiber necrosis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL339

Series:

GSE3252

8 Samples

Download data

(Submitter supplied) Determination of gene expression changes in extraocular muscle of mdx (dystrophin-deficient) mice at postnatal ages 14, 28, 56, and 112 days. 3 independent replicates/age/strain. Keywords = microarray Keywords = muscle Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS614

Platform:

GPL81

24 Samples

Download data: CEL

Analysis of extraocular muscle (EOM) from dystrophin-deficient mdx mice, a Duchenne muscular dystrophy (DMD) model. Postnatal ages 14, 28, 56, and 112 days examined. EOM is unaffected in DMD, so results provide insight into mdx EOM protective mechanisms.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 age, 2 strain sets

Platform:

GPL81

Series:

GSE1008

24 Samples

Download data: CEL

(Submitter supplied) Determination of gene expression changes in hindlimb muscle (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112. Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS639

Platform:

GPL81

36 Samples

Download data: CEL

Temporal analysis of hindlimb gastrocnemius/soleus muscle from dystrophin-deficient mdx mice, a Duchenne muscular dystrophy (DMD) model. Postnatal ages 7 to 112 days examined. Results provide insight into mechanisms of muscular dystrophy pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 6 age, 2 strain sets

Platform:

GPL81

Series:

GSE1025

36 Samples

Download data: CEL

(Submitter supplied) Comparative analysis of gene expression levels from hindlimb muscle tissue from 8 week old mouse models for muscular dystrophy. We have used mouse models with dystrophin-, sarcoglycan-, sarcospan-, or dysferlin-deficiency. Keywords = muscular dystrophy Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1770

26 Samples

Download data

(Submitter supplied) Expression profiles of six skeletal muscle types in mdx, mdx5cv and wildtype mice. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS641

Platform:

GPL81

36 Samples

Download data: CEL, EXP, RPT

Analysis of diaphragm, extensor digitorum longus, gastroc, soleus, quadricep, and tibialis anterior muscle in 8 week old male dystrophin-deficient mdx, mdx5cv, and C57BL10 wild type provides insight into pathogenesis of muscular dystrophy.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 strain, 6 tissue sets

Platform:

GPL81

Series:

GSE897

36 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) Determination of gene expression changes in extraocular and hindlimb (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal day 56. 5 independent replicates/muscle group/strain. Keywords: parallel sample

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS703

Platform:

GPL32

20 Samples

Download data: CEL

Analysis of extraocular (EOM) and hindlimb (gastrocnemius/soleus) muscle in mdx (dystrophin-deficient; Duchenne muscular dystrophy model) mice at postnatal day 56.5. Highly specific changes observed between dystrophic (leg) and spared (EOM) muscle.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 strain, 2 tissue sets

Platform:

GPL32

Series:

GSE1472

20 Samples

Download data: CEL

(Submitter supplied) Despite over 3,000 articles published on dystrophin in the last 15 years, the reasons underlying the progression of the human disease, differential muscle involvement, and disparate phenotypes in different species are not understood. The present experiment employed a screen of 12,488 mRNAs in 16-wk-old mouse mdx muscle at a time when the skeletal muscle is avoiding severe dystrophic pathophysiology, despite the absence of a functional dystrophin protein. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS236

Platform:

GPL81

10 Samples

Download data: CEL

Examination of mdx mouse, Duchenne muscular dystrophy model. 16 week regenerating mdx muscle analyzed in search for salvage pathways that maintain skeletal muscle integrity in the absence of functional dystrophin protein.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL81

Series:

GSE466

10 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL9454 GPL570

65 Samples

Download data: CEL

(Submitter supplied) Time-course microarray data set of mdx and wild type mice ranging from 1-20 weeks of age Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL485

36 Samples

Download data

(Submitter supplied) Albeit increased serum CK level and abnormal muscle histology are always present, boys with DMD are phenotipically indistinguishable from the normal ones at birth and, in their first years of life, acquire early motor milestones at normal times. A clear defect in muscle function becomes generally apparent by the end of the second year. As the disease is typically diagnosed between the ages of 3 and 7, the first two years are often considered and referred to as clinically presymptomatic. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3027

Platform:

GPL96

37 Samples

Download data: CEL, PDF

Analysis of skeletal muscles from 1.5 to 61 month old children with Duchenne muscular dystrophy (DMD). DMD is a degenerative skeletal muscle disease caused by mutations in the dystrophin gene. Results provide insight into the early phases of DMD pathogenesis and pathophysiology.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 22 age, 2 disease state, 2 gender sets

Platform:

GPL96

Series:

GSE6011

37 Samples

Download data: CEL

(Submitter supplied) Molecular profiles of dystophin-deficient patients and normal human skeletal muscles on Affymetrix HG-U95A arrays Keywords = DMD Keywords = Duchenne muscular dystrophy Keywords = dystrophin Keywords = Affymetrix U95A array Keywords = skeletal muscle Keywords = gene expression profiles Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS563

Platforms:

GPL8300 GPL91

24 Samples

Download data: CEL, EXP, RPT