GEO DataSets

Analysis of FVB/NJ liver treated with 45 mg/kg/day 4-nonylphenol (4-NP) for 32 weeks. 4-NP is an industrial waste and elicits estrogen-like responses. Results provide insight into molecular events altered by 4-NP.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL144

Series:

GSE1083

4 Samples

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(Submitter supplied) Alterations in gene expression in FVB/NJ mouse liver following 4-nonylphenol (4-NP) treatment for 32 weeks. Mice were treated with 45 mg/kg/day 4-NP for 32 weeks, livers excised and differential gene expression determined. Samples 1 and 2 are controls and samples 3 and 4 are mice treated with 4-NP. Arrays were visualized from the K-screen, and analyzed and quantified with a phosphoimager (Molecular Imager FX, Bio-Rad, Hercules, CA) and the ResGen PathwaysTM Universal Microarray Analysis SoftwareTM (Research Genetics, Carlsbad, CA). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS677

Platform:

GPL144

4 Samples

Download data

(Submitter supplied) We report the effects of exposure to the endocrine disruptor nonylphenol (NP) on transcriptome modification in the livers of in vivo Zebrafish. Our data indicate changes in fatty acid metabolism and inflammation, pathways associated with the development of Non-Alcoholic Fatty Liver Disease (NAFLD).

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15583

6 Samples

Download data: TXT

(Submitter supplied) We identify an unexpected functional role for E3 in fetal reproductive system and brain. We further identify a novel mechanism of estrogen action, through recruitment of epigenetic modifiers to estrogen receptors and their target genes, which doesn’t correlated with the traditional view of estrogen potency.”

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL21103

4 Samples

Download data: CSV, TXT, XLS, XLSX

(Submitter supplied) We identify an unexpected functional role for E3 in fetal reproductive system and brain. We further identify a novel mechanism of estrogen action, through recruitment of epigenetic modifiers to estrogen receptors and their target genes, which doesn’t correlated with the traditional view of estrogen potency.”

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL16791

8 Samples

Download data: BEDGRAPH

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array; Methylation profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

4 related Platforms

24 Samples

Download data: BEDGRAPH, CEL, CHP, GFF

(Submitter supplied) We identify an unexpected functional role for E3 in fetal reproductive system and brain. We further identify a novel mechanism of estrogen action, through recruitment of epigenetic modifiers to estrogen receptors and their target genes, which doesn’t correlated with the traditional view of estrogen potency.

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL18163

4 Samples

Download data: GFF, XLSX

(Submitter supplied) We identify an unexpected functional role for E3 in fetal reproductive system and brain. We further identify a novel mechanism of estrogen action, through recruitment of epigenetic modifiers to estrogen receptors and their target genes, which doesn’t correlated with the traditional view of estrogen potency.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL20775

8 Samples

Download data: CEL, CHP

(Submitter supplied) Nonylphenol (NP), is a bioaccumulative environmental estrogen that is widely used as a nonionic surfactant. We have previously examined short-term effects of NP on yeast cells using microarray technology. In the present study, we investigated the long-term impacts of NP on Saccharomyces cerevisiae BY4742 cells by analyzing genome-wide transcriptional profiles using RNA-sequencing. We used 2 mg/L NP concentration exposure for 40 days. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25927

6 Samples

Download data: XLSX