|
| Status |
Public on Mar 28, 2022 |
| Title |
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [methylation] |
| Organism |
Mus musculus |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
We identify an unexpected functional role for E3 in fetal reproductive system and brain. We further identify a novel mechanism of estrogen action, through recruitment of epigenetic modifiers to estrogen receptors and their target genes, which doesn’t correlated with the traditional view of estrogen potency.”
|
| |
|
| Overall design |
We administered E3 to pregnant mice, exposing the fetus to E3 and identified an unexpected functional role for E3 and a novel mechanism of estrogen action.
|
| |
|
| Contributor(s) |
Zhou Y, Taylor HS |
| Citation(s) |
35491423 |
| |
| Submission date |
Mar 25, 2022 |
| Last update date |
Jun 23, 2023 |
| Contact name |
Yuping Zhou |
| E-mail(s) |
joezhouyp@gmail.com
|
| Organization name |
Yale
|
| Department |
OB/GYN
|
| Lab |
Taylor Lab
|
| Street address |
310 cedar street
|
| City |
new haven |
| State/province |
CT |
| ZIP/Postal code |
06511 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (4)
|
|
| This SubSeries is part of SuperSeries: |
| GSE199214 |
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract |
|
| Relations |
| BioProject |
PRJNA819995 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE199434_CHG_result_table.txt.gz |
42.4 Mb |
(ftp)(http) |
TXT |
| GSE199434_CHG_result_table.xls.gz |
188.9 Kb |
(ftp)(http) |
XLS |
| GSE199434_CHH_result_table.txt.gz |
103.3 Mb |
(ftp)(http) |
TXT |
| GSE199434_CHH_result_table.xls.gz |
168.2 Kb |
(ftp)(http) |
XLS |
| GSE199434_CpG_result_table.txt.gz |
27.0 Mb |
(ftp)(http) |
TXT |
| GSE199434_CpG_result_table.xls.gz |
753.6 Kb |
(ftp)(http) |
XLS |
| GSE199434_FE311_vs_FCT14.CG.csv.gz |
241.5 Kb |
(ftp)(http) |
CSV |
| GSE199434_FE311_vs_FCT14.CHG.csv.gz |
78.3 Kb |
(ftp)(http) |
CSV |
| GSE199434_FE311_vs_FCT14.CHH.csv.gz |
214.1 Kb |
(ftp)(http) |
CSV |
| GSE199434_FE311_vs_FCT14_CG_top3000.xlsx |
260.0 Kb |
(ftp)(http) |
XLSX |
| GSE199434_FE311_vs_FCT14_CHG_top3000.xlsx |
212.3 Kb |
(ftp)(http) |
XLSX |
| GSE199434_FE311_vs_FCT14_CHH_top3000.xlsx |
212.6 Kb |
(ftp)(http) |
XLSX |
| GSE199434_methylation_and_rna_microarray_comparitions.xlsx |
377.7 Kb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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