GEO DataSet Links for PMC (Select 3342929) - GEO DataSets

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Items: 2

Select item 2000197771.

Antisense miRNA-221/222 (si221/222) and control inhibitor (GFP) treated fulvestrant-resistant breast cancer cells

(Submitter supplied) Full title: Expression data from antisense miRNA-221/222 (si221/222) and control inhibitor (GFP) treated fulvestrant-resistant breast cancer cells The expression of miR-221/222 were found to be upregulated in fulvestrant resistant breast cancer cells MCF7-FR compared to its drug-sensitive counterpart MCF7. To investigate the role of miR-221/222 in acquired resistance to fulvestrant, we lowered the level of miR-221/222 in MCF7-FR cells using miRNA inhibitors (antagomirs), and compared gene expression profiles before and after treatment.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4054
Platform:: GPL570
9 Samples

Download data: CEL

Series

Accession:: GSE19777

ID:: 200019777

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 40542.

microRNA-221/222 knockdown effect on fulvestrant-resistant MCF7 breast cancer cells

Analysis of fulvestrant-resistant MCF7 cells transfected with antisense miRNA inhibitors targeting miR-221 and miR-222. miR-221/222 knockdown inhibits cell proliferation in fulvestrant-resistant MCF7-F cells. Results provide insight into the role of miR-221/222 in acquired resistance to fulvestrant.