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Increased intron retention is a post-transcriptional signature associated with progressive ageing and Alzheimer’s disease

(Submitter supplied) Intron retention (IR) may affect gene expression and protein functions during development and age-onset diseases. However, it remains unclear if IR undergoes spatial or temporal changes during different stages of ageing or neurodegenerative disorders like Alzheimer’s disease (AD). By profiling mRNA species across different ages of Drosophila heads, we observed significant increase in the level of IR of many conserved genes as animals aged. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21306
12 Samples
Download data: TXT
Series
Accession:
GSE110349
ID:
200110349

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