GEO DataSets

(Submitter supplied) During liver infection, the malaria parasite undergoes massive replication whilst remaining clinically silent. Spatial coordination of immune response regulation and metabolic zonation during malaria infection in the true tissue context remains unexplored. We perform spatial transcriptomics combined with snRNA-seq over multiple time points to delineate transcriptional programs of host-pathogen interactions across P. more...

Organism:

Mus musculus; Plasmodium berghei ANKA

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL34512 GPL24247

6 Samples

Download data: MTX, TSV

(Submitter supplied) During liver infection, the malaria parasite undergoes massive replication whilst remaining clinically silent. Spatial coordination of immune response regulation and metabolic zonation during malaria infection in the true tissue context remains unexplored. We perform spatial transcriptomics combined with snRNA-seq over multiple time points to delineate transcriptional programs of host-pathogen interactions across P. more...

Organism:

Plasmodium berghei ANKA; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL34496

4 Samples

Download data: CSV, H5, JPG, JSON, PNG

(Submitter supplied) During liver infection, the malaria parasite undergoes massive replication whilst remaining clinically silent. Spatial coordination of immune response regulation and metabolic zonation during malaria infection in the true tissue context remains unexplored. We perform spatial transcriptomics combined with snRNA-seq over multiple time points to delineate transcriptional programs of host-pathogen interactions across P. more...

Organism:

Plasmodium berghei ANKA; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL34495 GPL34496

38 Samples

Download data: TSV

(Submitter supplied) To investigate the DNA-binding property of homeodomain-like domain of Plasmodium berghei HDP1, DNA immunoprecipitation followed by high-throughput sequencing (DIP-seq) analysis were performed. Recombinant homeodomain-like domain fused with glutathione S-transferase were mixed with the P. berghei genomic DNA fragmented via sonication, and protein-DNA complex was harvested using glutathione-sepharose resin. more...

Organism:

Plasmodium berghei ANKA

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL33514

2 Samples

Download data: XLS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium berghei ANKA

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:

GPL19670 GPL33514

20 Samples

Download data: TXT, XLS

(Submitter supplied) Plasmodium berghei transcriptomes of wild-type ANKA (WT) and garid knockout parasites [garid(-)] were analyzed at the gametocyte stage.

Organism:

Plasmodium berghei ANKA

Type:

Expression profiling by high throughput sequencing

Platform:

GPL33514

6 Samples

Download data: TXT

(Submitter supplied) To investigate the genome-wide binding sites of gARID in gametocytes of Plasmodium berghei, the chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) analyses were performed. Parasites expressing GFP-fused gARID were harvested after treating the infected mice with sulfadiazine and subjected to ChIP-seq experiments using anti-GFP antibody. Binding sites of gARID were determined from the sequence data.

Organism:

Plasmodium berghei ANKA

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL19670

12 Samples

Download data: TXT

(Submitter supplied) AP2-G is a transcription factor (TF) that is essential for gametocytogenesis of malaria parasites; however, the mechanisms for its inducing the cell linage for sexual reproduction remain unclear. In this paper, this problem is addressed by investigating its expression profile and by determining target genes genome-wide in Plasmodium berghei.

Organism:

Plasmodium berghei ANKA

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL19670

2 Samples

Download data: XLS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium berghei ANKA

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL19670

7 Samples

Download data: TXT, XLS

(Submitter supplied) AP2-G is a transcription factor (TF) that is essential for gametocytogenesis of malaria parasites; however, the mechanisms for its inducing the cell linage for sexual reproduction remain unclear. In this paper, this problem is addressed by investigating its expression profile and by determining target genes genome-wide in Plasmodium berghei.

Organism:

Plasmodium berghei ANKA

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL19670

4 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) AP2-G is a transcription factor (TF) that is essential for gametocytogenesis of malaria parasites; however, the mechanisms for its inducing the cell linage for sexual reproduction remain unclear. In this paper, this problem is addressed by investigating its expression profile and by determining target genes genome-wide in Plasmodium berghei.

Organism:

Plasmodium berghei ANKA

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19670

1 Sample

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium berghei ANKA

Type:

Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL15092 GPL19670

13 Samples

Download data: BEDGRAPH, BW, TXT

(Submitter supplied) Malaria gametocytes, the precursors of gametes, is the stage essential for malaria transmission to the mosquito vector. In the circulation they arise from asexual erythrocytic stages and then develop into mature females and males. Identification of sex-specific transcription factors is a key to understand biology of this stage. However, despite of intensive studies, none of them have been identified yet. more...

Organism:

Plasmodium berghei ANKA

Type:

Expression profiling by array

Platform:

GPL15092

9 Samples

Download data: TXT

(Submitter supplied) Malaria gametocytes, the precursors of gametes, is the stage essential for malaria transmission to the mosquito vector. In the circulation they arise from asexual erythrocytic stages and then develop into mature females and males. Identification of sex-specific transcription factors is a key to understand biology of this stage. However, despite of intensive studies, none of them have been identified yet. more...

Organism:

Plasmodium berghei ANKA

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL19670

4 Samples

Download data: BEDGRAPH, BW, TXT

(Submitter supplied) Plasmodium berghei transcriptome for female gametocytes, male gametocytes, and asexual erythrocytic stages

Organism:

Plasmodium berghei ANKA

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23858

9 Samples

Download data: TSV

(Submitter supplied) Bisulfite sequencing is a valuable tool for mapping the position of 5-methylcytosine in the genome at single base resolution. However, the associated chemistry renders the majority of DNA fragments unsequenceable, thus necessitating PCR amplification. Furthermore, bisulfite conversion generates an A,T-rich DNA library that leads to major PCR biases that may confound methylation analysis. Here we report a method that enables accurate methylation analysis, by rebuilding the damaged DNA library after bisulfite treatment. more...

Organism:

Plasmodium berghei ANKA

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL19670

5 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium berghei ANKA

Type:

Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL19817 GPL19816

22 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) Gametocytes are nonreplicative sexual forms that mediate malaria transmission to a mosquito vector. They are generated from asexual blood stage parasites, which proliferate in the circulation. However, it remains largely unknown as to how this transition is genetically regulated. Here, we report that an Apetala2 (AP2) family transcription factor, AP2-G2, regulates the transition as a transcriptional repressor. more...

Organism:

Plasmodium berghei ANKA

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL19817

4 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) Gametocytes are nonreplicative sexual forms that mediate malaria transmission to a mosquito vector. They are generated from asexual blood stage parasites, which proliferate in the circulation. However, it remains largely unknown as to how this transition is genetically regulated. Here, we report that an Apetala2 (AP2) family transcription factor, AP2-G2, regulates the transition as a transcriptional repressor. more...

Organism:

Plasmodium berghei ANKA

Type:

Expression profiling by array

Platform:

GPL19816

18 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium berghei; Plasmodium berghei ANKA

Type:

Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL18820 GPL15092 GPL18821

17 Samples

Download data: TXT