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Zmym6 zinc finger, MYM-type 6 [ Mus musculus (house mouse) ]

Gene ID: 100177, updated on 9-Dec-2024

Summary

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Official Symbol
Zmym6provided by MGI
Official Full Name
zinc finger, MYM-type 6provided by MGI
Primary source
MGI:MGI:106505
See related
Ensembl:ENSMUSG00000042408 AllianceGenome:MGI:106505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp258; D4Wsu24e; 9330177P20Rik
Summary
Predicted to be involved in cytoskeleton organization and regulation of cell morphogenesis. Is expressed in extraembryonic component. Orthologous to human ZMYM6 (zinc finger MYM-type containing 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E18 (RPKM 13.5), CNS E14 (RPKM 11.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Zmym6 in Genome Data Viewer
Location:
4 D2.2; 4 61.25 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126971176..127018167)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (127077383..127124374)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11418 Neighboring gene splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) Neighboring gene zinc finger, MYM domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9012 Neighboring gene STARR-seq mESC enhancer starr_11419 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11420 Neighboring gene predicted gene, 25600 Neighboring gene STARR-seq mESC enhancer starr_11421 Neighboring gene transmembrane protein 35B Neighboring gene STARR-seq mESC enhancer starr_11422 Neighboring gene 40S ribosomal protein S28 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Yoshida Y, et al. Neuron, 2006 Dec 7. PMID 17145500, Free PMC Article
  2. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
  3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger MYM-type protein 6
Names
likely ortholog of H. sapiens zinc finger protein 258 (ZNF258)
probably fused to an N terminal zinc finger domain
transposase-like protein
zinc finger protein 258

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285885.1 → NP_001272814.1  zinc finger MYM-type protein 6 isoform a

    See identical proteins and their annotated locations for NP_001272814.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AK035136, BC094598
    Consensus CDS
    CCDS18664.1
    UniProtKB/TrEMBL
    B2RU44, Q8BS54
    Conserved Domains (1) summary
    pfam06467
    Location:116 → 159
    zf-FCS; MYM-type Zinc finger with FCS sequence motif

  2. NM_001285887.1 → NP_001272816.1  zinc finger MYM-type protein 6 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK035136, AK081836, BC094598
    Consensus CDS
    CCDS71469.1
    UniProtKB/TrEMBL
    A2A7U2, B2RU44
    Related
    ENSMUSP00000092303.4, ENSMUST00000094713.4
    Conserved Domains (1) summary
    pfam06467
    Location:116 → 159
    zf-FCS; MYM-type Zinc finger with FCS sequence motif

  3. NM_001285888.1 → NP_001272817.1  zinc finger MYM-type protein 6 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has alternate 5' exon structure and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK035136, AL606985, BC094598
    UniProtKB/TrEMBL
    Q8K048
    Conserved Domains (1) summary
    pfam06467
    Location:14 → 57
    zf-FCS; MYM-type Zinc finger with FCS sequence motif

  4. NM_177462.5 → NP_803413.1  zinc finger MYM-type protein 6 isoform a

    See identical proteins and their annotated locations for NP_803413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AK035136, BC094598
    Consensus CDS
    CCDS18664.1
    UniProtKB/TrEMBL
    B2RU44, Q8BS54
    Related
    ENSMUSP00000045366.7, ENSMUST00000046751.13
    Conserved Domains (1) summary
    pfam06467
    Location:116 → 159
    zf-FCS; MYM-type Zinc finger with FCS sequence motif

RNA

  1. NR_104366.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) includes an additional exon in the 5' region, uses an alternate splice site in the central region, and lacks a segment in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK035136, AL606985, BC094598

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    126971176..127018167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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