BCL2L11 BCL2 like 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BCL2L11provided by HGNC
Official Full Name: BCL2 like 11provided by HGNC
Primary source: HGNC:HGNC:994
See related: Ensembl:ENSG00000153094 MIM:603827; AllianceGenome:HGNC:994
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAM; BIM; BOD
Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
Expression: Ubiquitous expression in lymph node (RPKM 7.9), thyroid (RPKM 7.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (111120914..111168445)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (111543978..111591507)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (111878491..111926022)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pokemon inhibits Bim transcription to promote the proliferation, anti-anoikis, invasion, histological grade, and dukes stage of colorectal neoplasms.
Title: Pokemon inhibits Bim transcription to promote the proliferation, anti-anoikis, invasion, histological grade, and dukes stage of colorectal neoplasms.
Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy.
Title: Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy.
Coexpression of TP53, BIM, and PTEN Enhances the Therapeutic Efficacy of Non-Small-Cell Lung Cancer.
Title: Coexpression of TP53, BIM, and PTEN Enhances the Therapeutic Efficacy of Non-Small-Cell Lung Cancer.
Protein interaction networks characterizing the A549 cells Klotho transfected are associated with activated pro-apoptotic Bim and suppressed Wnt/beta-catenin signaling pathway.
Title: Protein interaction networks characterizing the A549 cells Klotho transfected are associated with activated pro-apoptotic Bim and suppressed Wnt/β-catenin signaling pathway.
Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis.
Title: Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis.
Expression Levels of MicroRNA-300/BCL2L11 in Papillary Thyroid Cancer and Their Clinical Diagnostic Values.
Title: Expression Levels of MicroRNA-300/BCL2L11 in Papillary Thyroid Cancer and Their Clinical Diagnostic Values.
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
Title: Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
miR-24-3p down-regulates the expression of the apoptotic factors FasL and BIM in human natural killer cells.
Title: miR-24-3p down-regulates the expression of the apoptotic factors FasL and BIM in human natural killer cells.
MicroRNA-17-5p Protects against Propofol Anesthesia-Induced Neurotoxicity and Autophagy Impairment via Targeting BCL2L11.
Title: MicroRNA-17-5p Protects against Propofol Anesthesia-Induced Neurotoxicity and Autophagy Impairment via Targeting BCL2L11.
Significant role of long non-coding RNA MALAT1 in deep vein thrombosis via the regulation of vascular endothelial cell physiology through the microRNA-383-5p/BCL2L11 axis.
Title: Significant role of long non-coding RNA MALAT1 in deep vein thrombosis via the regulation of vascular endothelial cell physiology through the microRNA-383-5p/BCL2L11 axis.

Submit: New GeneRIF Correction See all GeneRIFs (396)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2018-06-21) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2018-06-21) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates BIM expression in Tat-infected Jurkat T cells	PubMed
	tat	HIV-1 Tat acetylation at position K28 stimulates its activity to induce the translocation of Bim, a pro-apoptotic protein of the Bcl-2 family, from microtubules to mitochondria	PubMed
	tat	HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH99076 (e-PCR)
- UniSTS:90012

RH91369 (e-PCR)
- UniSTS:85445

D2S1892 (e-PCR), detects polymorphism
- UniSTS:66798

WI-11737 (e-PCR)
- UniSTS:72182

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in T cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in apoptotic process involved in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucocorticoid stimulus	TAS Traceable Author Statement more info	PubMed
involved_in developmental pigmentation	IEA Inferred from Electronic Annotation more info
involved_in ear development	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	IDA Inferred from Direct Assay more info	PubMed
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in mammary gland development	IEA Inferred from Electronic Annotation more info
involved_in meiosis I	IBA Inferred from Biological aspect of Ancestor more info
involved_in myeloid cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of IRE1-mediated unfolded protein response	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of T cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of fibroblast apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of release of cytochrome c from mitochondria	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in regulation of developmental pigmentation	IEA Inferred from Electronic Annotation more info
involved_in regulation of organ growth	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spleen development	IEA Inferred from Electronic Annotation more info
involved_in thymocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in thymus development	IEA Inferred from Electronic Annotation more info
involved_in tube formation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of BIM-BCL-2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of BIM-BCL-xl complex	IDA Inferred from Direct Assay more info	PubMed
part_of Bcl-2 family protein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
colocalizes_with microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	TAS Traceable Author Statement more info
located_in mitochondrion	HTP more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bcl-2-like protein 11

Names: BCL2-like 11 (apoptosis facilitator); bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; bcl-2-related ovarian death agonist

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029006.1 RefSeqGene

Range

5001..52532

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_620

mRNA and Protein(s)

NM_001204106.2 → NP_001191035.1 bcl-2-like protein 11 isoform 11

See identical proteins and their annotated locations for NP_001191035.1

Status: REVIEWED

Description

Transcript Variant: This variant (11, also known as BimS) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (11) is shorter, compared to isoform 1.

Source sequence(s)

AC096670, AI268146, AK290377, AY305714

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:46 → 76

Bclx_interact; Bcl-x interacting, BH3 domain
NM_001204107.1 → NP_001191036.1 bcl-2-like protein 11 isoform 12

See identical proteins and their annotated locations for NP_001191036.1

Status: REVIEWED

Description

Transcript Variant: This variant (12) uses an alternate in-frame splice site in the 5' coding region, contains two alternate internal exons, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (12) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AC096670, AI268146, AK290377, AY423442

Consensus CDS

CCDS56132.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000411137.1, ENST00000439718.1

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:46 → 73

Bclx_interact; Bcl-x interacting, BH3 domain
NM_001204108.1 → NP_001191037.1 bcl-2-like protein 11 isoform 13

See identical proteins and their annotated locations for NP_001191037.1

Status: REVIEWED

Description

Transcript Variant: This variant (13) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (13) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AC096670, AI268146, AK290377, AY423443

Consensus CDS

CCDS56135.1

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:132 → 163

Bclx_interact; Bcl-x interacting, BH3 domain
NM_001204109.2 → NP_001191038.1 bcl-2-like protein 11 isoform 14

See identical proteins and their annotated locations for NP_001191038.1

Status: REVIEWED

Description

Transcript Variant: This variant (14) lacks an internal exon, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (14) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AC096670, AI268146, AK290377, AY428962

Consensus CDS

CCDS56136.1

UniProtKB/TrEMBL

C9J417

Related

ENSP00000403727.1, ENST00000436733.5

Conserved Domains (1) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus
NM_001204110.2 → NP_001191039.1 bcl-2-like protein 11 isoform 15

See identical proteins and their annotated locations for NP_001191039.1

Status: REVIEWED

Description

Transcript Variant: This variant (15) uses an alternate in-frame splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (15) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AC096670, AI268146, AK290377, DQ849200

Consensus CDS

CCDS56133.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000391292.1, ENST00000452231.5

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:46 → 73

Bclx_interact; Bcl-x interacting, BH3 domain
NM_001204111.2 → NP_001191040.1 bcl-2-like protein 11 isoform 16

See identical proteins and their annotated locations for NP_001191040.1

Status: REVIEWED

Description

Transcript Variant: This variant (16) lacks an in-frame segment in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (16) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC096670, AI268146, AK290377, DQ849201

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus
NM_001204112.2 → NP_001191041.1 bcl-2-like protein 11 isoform 17

See identical proteins and their annotated locations for NP_001191041.1

Status: REVIEWED

Description

Transcript Variant: This variant (17) lacks an alternate in-frame segment in the 5' coding region, lacks an internal exon, and contains an alternate internal exon, compared to variant 1. The resulting isoform (17) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AC096670, AI268146, AK290377, DQ849202

Consensus CDS

CCDS56131.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000393781.1, ENST00000415458.5

Conserved Domains (1) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus
NM_001204113.1 → NP_001191042.1 bcl-2-like protein 11 isoform 18

See identical proteins and their annotated locations for NP_001191042.1

Status: REVIEWED

Description

Transcript Variant: This variant (18) lacks an alternate in-frame segment and differs in the 3' UTR and coding sequence, compared to variant 1. The resulting isoform (18) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC096670, AK290377, AW629314

Consensus CDS

CCDS74559.1

UniProtKB/TrEMBL

H7BZE5

Related

ENSP00000389225.2, ENST00000438054.2

Conserved Domains (1) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus
NM_006538.5 → NP_006529.1 bcl-2-like protein 11 isoform 6

See identical proteins and their annotated locations for NP_006529.1

Status: REVIEWED

Description

Transcript Variant: This variant (6, also known as BimL) lacks an in-frame segment in the 5' coding coding region, compared to variant 1. The resulting isoform (6) is shorter, compared to isoform 1.

Source sequence(s)

AC096670, AF032458, AI268146, AK290377, BC033694

Consensus CDS

CCDS42731.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000309226.8, ENST00000308659.12

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:70 → 106

Bclx_interact; Bcl-x interacting, BH3 domain
NM_138621.5 → NP_619527.1 bcl-2-like protein 11 isoform 1

See identical proteins and their annotated locations for NP_619527.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as BimEL) encodes the longest isoform (1).

Source sequence(s)

AC096670, AI268146, BC033694

Consensus CDS

CCDS2089.1

UniProtKB/Swiss-Prot

A8K2W2, O43521, O43522, Q0MSE7, Q0MSE8, Q0MSE9, Q53R28, Q6JTU6, Q6T851, Q6TE14, Q6TE15, Q6TE16, Q6V402, Q8WYL6, Q8WYL7, Q8WYL8, Q8WYL9, Q8WYM0, Q8WYM1

Related

ENSP00000376943.2, ENST00000393256.8

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:130 → 166

Bclx_interact; Bcl-x interacting, BH3 domain
NM_138622.4 → NP_619528.1 bcl-2-like protein 11 isoform 2

See identical proteins and their annotated locations for NP_619528.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as Bim-alpha1) contains an alternate internal exon and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AB071195, AC096670, AI268146, AK290377

Consensus CDS

CCDS74560.1

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:132 → 163

Bclx_interact; Bcl-x interacting, BH3 domain
NM_138623.4 → NP_619529.1 bcl-2-like protein 11 isoform 3

See identical proteins and their annotated locations for NP_619529.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as Bim-ACD and Bim-alpha2) lacks a 5' segment, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AB071196, AC096670, AI268146, AK290377

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:76 → 103

Bclx_interact; Bcl-x interacting, BH3 domain
NM_138624.4 → NP_619530.1 bcl-2-like protein 11 isoform 4

See identical proteins and their annotated locations for NP_619530.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as Bim-beta1) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AB071197, AC096670, AI268146, AK290377

Consensus CDS

CCDS56134.1

UniProtKB/TrEMBL

C9J417

Conserved Domains (1) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus
NM_138625.4 → NP_619531.1 bcl-2-like protein 11 isoform 5

See identical proteins and their annotated locations for NP_619531.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as Bim-beta3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AB071199, AC096670, AI268146, AK290377

UniProtKB/TrEMBL

A0A0C4DH20

Related

ENSP00000354879.6, ENST00000361493.10

Conserved Domains (1) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus
NM_138626.4 → NP_619532.1 bcl-2-like protein 11 isoform 7

See identical proteins and their annotated locations for NP_619532.1

Status: REVIEWED

Description

Transcript Variant: This variant (7, also known as Bim-ABC and Bim-beta2) lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AB071198, AC096670, AI268146, AK290377

Consensus CDS

CCDS74561.1

UniProtKB/TrEMBL

C9J417

Conserved Domains (1) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus
NM_138627.4 → NP_619533.1 bcl-2-like protein 11 isoform 8

See identical proteins and their annotated locations for NP_619533.1

Status: REVIEWED

Description

Transcript Variant: This variant (8, also known as Bim-A and Bim-beta4) uses an alternate splice site in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (8) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AB071200, AC096670, AI268146, AK290377

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus
NM_207002.3 → NP_996885.1 bcl-2-like protein 11 isoform 9

See identical proteins and their annotated locations for NP_996885.1

Status: REVIEWED

Description

Transcript Variant: This variant (9, also known as Bim-gamma) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (9) has a distinct and shorter C-terminus, compared to isoform 1.

Source sequence(s)

AA890664, AC096670, AK290377, AY352518

Consensus CDS

CCDS2092.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000384641.1, ENST00000405953.6

Conserved Domains (1) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus
NM_207003.3 → NP_996886.1 bcl-2-like protein 11 isoform 10

See identical proteins and their annotated locations for NP_996886.1

Status: REVIEWED

Description

Transcript Variant: This variant (10, also known as Bim-alpha3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (10) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AC096670, AI268146, AK290377, AY305715

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:42 → 73

Bclx_interact; Bcl-x interacting, BH3 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

111120914..111168445

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047442102.1 → XP_047298058.1 bcl-2-like protein 11 isoform X6
XM_005263556.4 → XP_005263613.1 bcl-2-like protein 11 isoform X8

See identical proteins and their annotated locations for XP_005263613.1

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:132 → 163

Bclx_interact; Bcl-x interacting, BH3 domain
XM_005263553.4 → XP_005263610.1 bcl-2-like protein 11 isoform X4

UniProtKB/TrEMBL

A0AA75IMJ6

Conserved Domains (2) summary

pfam06773
Location:98 → 134

Bim_N; Bim protein N-terminus

pfam08945
Location:166 → 197

Bclx_interact; Bcl-x interacting, BH3 domain
XM_017003101.3 → XP_016858590.1 bcl-2-like protein 11 isoform X12

UniProtKB/TrEMBL

A0AA75IMJ6
XM_005263552.5 → XP_005263609.1 bcl-2-like protein 11 isoform X3

Conserved Domains (2) summary

pfam06773
Location:98 → 134

Bim_N; Bim protein N-terminus

pfam08945
Location:166 → 197

Bclx_interact; Bcl-x interacting, BH3 domain
XM_047442104.1 → XP_047298060.1 bcl-2-like protein 11 isoform X11

UniProtKB/TrEMBL

A0AA75IMJ6
XM_011510464.4 → XP_011508766.1 bcl-2-like protein 11 isoform X9

Conserved Domains (1) summary

pfam06773
Location:98 → 134

Bim_N; Bim protein N-terminus
XM_005263559.4 → XP_005263616.2 bcl-2-like protein 11 isoform X10
XM_047442099.1 → XP_047298055.1 bcl-2-like protein 11 isoform X2

Related

ENSP00000412892.1, ENST00000437029.5
XM_005263555.5 → XP_005263612.2 bcl-2-like protein 11 isoform X7
XM_047442101.1 → XP_047298057.1 bcl-2-like protein 11 isoform X5

UniProtKB/TrEMBL

C9J417

Related

ENSP00000394640.1, ENST00000431217.1
XM_011510461.4 → XP_011508763.2 bcl-2-like protein 11 isoform X1
XM_005263557.5 → XP_005263614.1 bcl-2-like protein 11 isoform X8

See identical proteins and their annotated locations for XP_005263614.1

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:132 → 163

Bclx_interact; Bcl-x interacting, BH3 domain

RNA

XR_007068189.1 RNA Sequence
XR_007068187.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

111543978..111591507

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054340063.1 → XP_054196038.1 bcl-2-like protein 11 isoform X6
XM_054340070.1 → XP_054196045.1 bcl-2-like protein 11 isoform X8
XM_054340055.1 → XP_054196030.1 bcl-2-like protein 11 isoform X14

UniProtKB/TrEMBL

E9PAM9
XM_054340061.1 → XP_054196036.1 bcl-2-like protein 11 isoform X18
XM_054340060.1 → XP_054196035.1 bcl-2-like protein 11 isoform X4

UniProtKB/TrEMBL

A0AA75IMJ6
XM_054340069.1 → XP_054196044.1 bcl-2-like protein 11 isoform X12

UniProtKB/TrEMBL

A0AA75IMJ6
XM_054340067.1 → XP_054196042.1 bcl-2-like protein 11 isoform X21
XM_054340057.1 → XP_054196032.1 bcl-2-like protein 11 isoform X16
XM_054340054.1 → XP_054196029.1 bcl-2-like protein 11 isoform X13
XM_054340059.1 → XP_054196034.1 bcl-2-like protein 11 isoform X3
XM_054340064.1 → XP_054196039.1 bcl-2-like protein 11 isoform X20
XM_054340062.1 → XP_054196037.1 bcl-2-like protein 11 isoform X19
XM_054340058.1 → XP_054196033.1 bcl-2-like protein 11 isoform X17
XM_054340068.1 → XP_054196043.1 bcl-2-like protein 11 isoform X11

UniProtKB/TrEMBL

A0AA75IMJ6
XM_054340056.1 → XP_054196031.1 bcl-2-like protein 11 isoform X15
XM_054340066.1 → XP_054196041.1 bcl-2-like protein 11 isoform X9
XM_054340065.1 → XP_054196040.1 bcl-2-like protein 11 isoform X8