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Kank2 KN motif and ankyrin repeat domains 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100361376, updated on 10-Jul-2024

Summary

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Official Symbol
Kank2provided by RGD
Official Full Name
KN motif and ankyrin repeat domains 2provided by RGD
Primary source
RGD:2320289
See related
EnsemblRapid:ENSRNOG00000010643 AllianceGenome:RGD:2320289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563532
Summary
Predicted to be involved in several processes, including glomerular visceral epithelial cell migration; negative regulation of G1/S transition of mitotic cell cycle; and regulation of signal transduction. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16. Orthologous to human KANK2 (KN motif and ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 355.2), Lung (RPKM 228.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kank2 in Genome Data Viewer
Location:
8q13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28587770..28617212, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20311676..20341107, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22792000..22821459, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor Neighboring gene SPC24 component of NDC80 kinetochore complex Neighboring gene dedicator of cytokinesis 6 Neighboring gene angiopoietin-like 8 Neighboring gene uncharacterized LOC120094090

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Therapeutic effects of KANK2 in myocardial infarction rats might be associated with the NF-κB p65 inhibition. Li L, et al. Int Immunopharmacol, 2020 Sep. PMID 32570033
  2. CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases. Jurewicz E, et al. Neurochem Int, 2020 Sep. PMID 32544715
  3. Mutation in KANK2, encoding a sequestering protein for steroid receptor coactivators, causes keratoderma and woolly hair. Ramot Y, et al. J Med Genet, 2014 Jun. PMID 24671081
  4. Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria. Wang D, et al. J Biol Chem, 2012 Apr 13. PMID 22371500, Free PMC Article
  5. SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. Zhang Y, et al. EMBO J, 2007 Jun 6. PMID 17476305, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases.
    Title: CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases.
  2. Therapeutic effects of KANK2 in myocardial infarction rats might be associated with the NF-kappaB p65 inhibition.
    Title: Therapeutic effects of KANK2 in myocardial infarction rats might be associated with the NF-κB p65 inhibition.
  3. In rats, KANK1, KANK2, and KANK4 all localized to podocytes in glomeruli, and KANK1 partially colocalized with synaptopodin.
    Title: KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in kidney epithelium development IEA
Inferred from Electronic Annotation
more info
  
involved_in kidney epithelium development ISO
Inferred from Sequence Orthology
more info
  
involved_in kidney epithelium development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of intracellular estrogen receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of intracellular estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vitamin D receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of vitamin D receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of vitamin D receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in podocyte cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in podocyte cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in podocyte cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
KN motif and ankyrin repeat domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270413.1 → NP_001257342.1  KN motif and ankyrin repeat domain-containing protein 2

    See identical proteins and their annotated locations for NP_001257342.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8L2QNK4, A6JNU5, D4ACC2
    Conserved Domains (6) summary
    cd00204
    Location:650 → 781
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12075
    Location:31 → 59
    KN_motif; KN motif
    pfam12796
    Location:660 → 758
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:631 → 676
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:747 → 802
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:728 → 758
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    28587770..28617212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242589.5 → XP_006242651.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006242651.1

    UniProtKB/Swiss-Prot
    D3ZD05
    UniProtKB/TrEMBL
    A0A8L2QNK4
    Conserved Domains (5) summary
    cd00204
    Location:657 → 788
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:735 → 765
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 59
    KN_motif; KN motif
    pfam12796
    Location:624 → 687
    Ank_2; Ankyrin repeats (3 copies)
    cl00478
    Location:438 → 580
    LGT; Prolipoprotein diacylglyceryl transferase

  2. XM_006242590.5 → XP_006242652.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006242652.1

    UniProtKB/Swiss-Prot
    D3ZD05
    UniProtKB/TrEMBL
    A0A8L2QNK4
    Related
    ENSRNOP00000014135.6, ENSRNOT00000014135.9
    Conserved Domains (5) summary
    cd00204
    Location:657 → 788
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:735 → 765
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 59
    KN_motif; KN motif
    pfam12796
    Location:624 → 687
    Ank_2; Ankyrin repeats (3 copies)
    cl00478
    Location:438 → 580
    LGT; Prolipoprotein diacylglyceryl transferase

  3. XM_063264709.1 → XP_063120779.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    D3ZD05
    UniProtKB/TrEMBL
    A0A8L2QNK4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZD05.2 GenPept UniProtKB/Swiss-Prot:D3ZD05

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