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Eef1akmt4 EEF1A lysine methyltransferase 4 [ Mus musculus (house mouse) ]

Gene ID: 110599566, updated on 18-Sep-2024

Summary

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Official Symbol
Eef1akmt4provided by MGI
Official Full Name
EEF1A lysine methyltransferase 4provided by MGI
Primary source
MGI:MGI:5903914
See related
Ensembl:ENSMUSG00000115219 AllianceGenome:MGI:5903914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the lysine-specific methyltransferase (KMT) family. The encoded enzyme catalyzes the methylation of lysine-36 of the eukaryotic translation elongation factor 1 alpha. Methylation by this enzyme may affect endoplasmic reticulum-related processes. [provided by RefSeq, Jul 2017]
Annotation information
Note: This gene was annotated as Ece2 (GeneID:107522) until recently in Annotation Release 106. It is now annotated as an independent gene adjacent to GeneID:107522 based on a published report in a human study (PMID:28520920). [12 Jul 2017]
Orthologs
human all
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Genomic context

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See Eef1akmt4 in Genome Data Viewer
Location:
16 A3; 16
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20430351..20437619)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20611601..20618869)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene von Willebrand factor A domain containing 5B2 Neighboring gene microRNA 1224 Neighboring gene STARR-positive B cell enhancer ABC_E10894 Neighboring gene ALG3 alpha-1,3- mannosyltransferase Neighboring gene Eef1akmt4-endothelin converting enzyme 2 readthrough Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene endothelin converting enzyme 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Readthrough Eef1ece2

Readthrough gene: Eef1ece2, Included gene: Ece2

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-lysine N-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EEF1A lysine methyltransferase 4
Names
eukaryotic translation elongation factor 1 alpha lysine specific methyltransferase 4
NP_079738.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025462.2 → NP_079738.2  EEF1A lysine methyltransferase 4

    See identical proteins and their annotated locations for NP_079738.2

    Status: VALIDATED

    Source sequence(s)
    BC115541, BE956299
    Consensus CDS
    CCDS37290.1
    UniProtKB/Swiss-Prot
    P0DPE0
    Related
    ENSMUSP00000111184.3, ENSMUST00000115522.10
    Conserved Domains (1) summary
    pfam13649
    Location:62 → 169
    Methyltransf_25; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    20430351..20437619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DPE0.1 GenPept UniProtKB/Swiss-Prot:P0DPE0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases