Eef1ece2 Eef1akmt4-endothelin converting enzyme 2 readthrough [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eef1ece2provided by MGI
Official Full Name: Eef1akmt4-endothelin converting enzyme 2 readthroughprovided by MGI
Primary source: MGI:MGI:6121518
See related: Ensembl:ENSMUSG00000115293 AllianceGenome:MGI:6121518
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm49333; Eef1akmt4; Eef1akmt4-ece2
Summary: This locus represents naturally occurring readthrough transcription between the adjacent genes eukaryotic translation elongation factor 1 alpha lysine specific methyltransferase 4 (GeneID:110599566) and endothelin converting enzyme 2 (GeneID:107522). The readthrough transcript representing this gene encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2017]
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Genomic context

Location:: 16 A3; 16

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (20430351..20464665)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (20611601..20645915)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardioblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in peptide hormone processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in transport vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Eef1akmt4-Ece2 readthrough

Names: EEF1A lysine methyltransferase 4; EEF1AKMT4-ECE2 readthrough transcript protein

NP_808809.1

EC 2.1.1.-

EC 3.4.24.71

NP_808810.1

EC 2.1.1.-

EC 3.4.24.71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177940.1 → NP_808809.1 Eef1akmt4-Ece2 readthrough isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2, also known as 2a-1) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as 2a-1) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC087898, AF489569, AF489572, AU080537, BC115541

UniProtKB/Swiss-Prot

E9QKA6, P0DPD9, Q14BY3, Q80Z59, Q80Z60, Q9D8Q9, Q9D928

UniProtKB/TrEMBL

Q923T6

Related

ENSMUSP00000078550.5, ENSMUST00000079600.12

Conserved Domains (2) summary

cd08662
Location:230 → 879

M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

pfam13649
Location:62 → 128

Methyltransf_25; Methyltransferase domain
NM_177941.1 → NP_808810.1 Eef1akmt4-Ece2 readthrough isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1, also known as 2a-2) represents the longer transcript and encodes the longer isoform (a, also known as 2a-2).

Source sequence(s)

AC087898, AF489570, AF489572, AU080537, BC115541

UniProtKB/TrEMBL

Q923T6

Related

ENSMUSP00000113475.2, ENSMUST00000120394.8

Conserved Domains (3) summary

cd08662
Location:259 → 908

M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

COG3590
Location:248 → 901

PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

cl17173
Location:63 → 128

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...