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Api5 apoptosis inhibitor 5 [ Mus musculus (house mouse) ]

Gene ID: 11800, updated on 5-Mar-2024

Summary

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Official Symbol
Api5provided by MGI
Official Full Name
apoptosis inhibitor 5provided by MGI
Primary source
MGI:MGI:1888993
See related
Ensembl:ENSMUSG00000027193 AllianceGenome:MGI:1888993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
API-5; AAC-11
Summary
Predicted to enable RNA binding activity and fibroblast growth factor binding activity. Acts upstream of or within negative regulation of fibroblast apoptotic process. Part of spliceosomal complex. Is expressed in central nervous system and retina. Orthologous to human API5 (apoptosis inhibitor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 28.3), bladder adult (RPKM 22.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Api5 in Genome Data Viewer
Location:
2 E1; 2 51.84 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (94242073..94268490, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (94411727..94438186, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 17 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) pseudogene 1 Neighboring gene RIKEN cDNA 2810002D19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr2:94278212-94278513 Neighboring gene STARR-positive B cell enhancer mm9_chr2:94306013-94306313 Neighboring gene STARR-seq mESC enhancer starr_05179 Neighboring gene predicted gene 13788 Neighboring gene predicted gene, 24318

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death. Matsuzawa-Ishimoto Y, et al. Nature, 2022 Oct. PMID 36198790, Free PMC Article
  2. AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Tewari M, et al. Cancer Res, 1997 Sep 15. PMID 9307294
  3. Myb proteins regulate the expression of diverse target genes. Lang G, et al. Oncogene, 2005 Feb 17. PMID 15608679
  4. Identification of genes differentially expressed in vascular smooth muscle cells following benzo[a]pyrene challenge: implications for chemical atherogenesis. Lu KP, et al. Biochem Biophys Res Commun, 1998 Dec 30. PMID 9918813
  5. Maternal diabetes alters transcriptional programs in the developing embryo. Pavlinkova G, et al. BMC Genomics, 2009 Jun 18. PMID 19538749, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The gammadelta IEL effector API5 masks genetic susceptibility to Paneth cell death.
    Title: The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in localization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
apoptosis inhibitor 5
Names
apoptosis inhibitory protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305258.2 → NP_001292187.1  apoptosis inhibitor 5 isoform 1

    See identical proteins and their annotated locations for NP_001292187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL672251
    UniProtKB/TrEMBL
    Q3UYQ4
    Conserved Domains (3) summary
    pfam05918
    Location:4 → 495
    API5; Apoptosis inhibitory protein 5 (API5)
    pfam13646
    Location:70 → 156
    HEAT_2; HEAT repeats
    sd00044
    Location:63 → 91
    HEAT; HEAT repeat [structural motif]

  2. NM_001349003.2 → NP_001335932.1  apoptosis inhibitor 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL672251
    Conserved Domains (2) summary
    sd00044
    Location:63 → 91
    HEAT; HEAT repeat [structural motif]
    pfam05918
    Location:4 → 504
    API5; Apoptosis inhibitory protein 5 (API5)

  3. NM_007466.4 → NP_031492.2  apoptosis inhibitor 5 isoform 2

    See identical proteins and their annotated locations for NP_031492.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' coding region that results in a frame-shift compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL672251
    Consensus CDS
    CCDS16459.1
    UniProtKB/Swiss-Prot
    O35841, Q3U517, Q922L2
    Related
    ENSMUSP00000028617.7, ENSMUST00000028617.7
    Conserved Domains (3) summary
    pfam05918
    Location:4 → 495
    API5; Apoptosis inhibitory protein 5 (API5)
    pfam13646
    Location:70 → 156
    HEAT_2; HEAT repeats
    sd00044
    Location:63 → 91
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    94242073..94268490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35841.2 GenPept UniProtKB/Swiss-Prot:O35841

Gene LinkOut

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