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ZNF578 zinc finger protein 578 [ Homo sapiens (human) ]

Gene ID: 147660, updated on 10-Dec-2024

Summary

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Official Symbol
ZNF578provided by HGNC
Official Full Name
zinc finger protein 578provided by HGNC
Primary source
HGNC:HGNC:26449
See related
Ensembl:ENSG00000258405 AllianceGenome:HGNC:26449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in testis (RPKM 3.0), thyroid (RPKM 0.7) and 14 other tissues See more
Orthologs
all
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Genomic context

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See ZNF578 in Genome Data Viewer
Location:
19q13.41
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52453553..52516882)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55538104..55601470)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52956806..53020135)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 5 pseudogene 1 Neighboring gene zinc finger protein 534 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52956248-52957447 Neighboring gene DUT pseudogene Neighboring gene zinc finger protein 347 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:52986584-52987370 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:52987371-52988156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52990721-52991690 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:52996369-52997007 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:52997008-52997645 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53003665-53004504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53029540-53030366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53030367-53031194 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53039321-53039907 Neighboring gene zinc finger protein 808 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53061637-53062248 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53062249-53062862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53072140-53072749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15051 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53073969-53074577 Neighboring gene ribosomal protein L39 pseudogene 34 Neighboring gene zinc finger protein 701 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53091538-53091757 Neighboring gene zinc finger protein 137, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
  2. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31384

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 578
Names
Putative chemokine-related protein B42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099694.2 → NP_001093164.1  zinc finger protein 578

    See identical proteins and their annotated locations for NP_001093164.1

    Status: VALIDATED

    Source sequence(s)
    AC010332, AC022150, AK055946, BC115704, BX955279
    Consensus CDS
    CCDS54310.1
    UniProtKB/Swiss-Prot
    B4DR51, I3L1Y6, Q96N58
    Related
    ENSP00000459216.1, ENST00000421239.7
    Conserved Domains (3) summary
    COG5048
    Location:257 → 582
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:24 → 64
    KRAB; KRAB box

  2. NM_001366182.2 → NP_001353111.1  zinc finger protein 578

    Status: VALIDATED

    Source sequence(s)
    AC010332, AC010506, AC022150
    Consensus CDS
    CCDS54310.1
    UniProtKB/Swiss-Prot
    B4DR51, I3L1Y6, Q96N58
    Conserved Domains (3) summary
    COG5048
    Location:257 → 582
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:24 → 64
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52453553..52516882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438189.1 → XP_047294145.1  zinc finger protein 578 isoform X1

    UniProtKB/Swiss-Prot
    B4DR51, I3L1Y6, Q96N58

  2. XM_047438194.1 → XP_047294150.1  zinc finger protein 578 isoform X2

  3. XM_047438191.1 → XP_047294147.1  zinc finger protein 578 isoform X1

    UniProtKB/Swiss-Prot
    B4DR51, I3L1Y6, Q96N58

  4. XM_047438190.1 → XP_047294146.1  zinc finger protein 578 isoform X1

    UniProtKB/Swiss-Prot
    B4DR51, I3L1Y6, Q96N58

  5. XM_047438192.1 → XP_047294148.1  zinc finger protein 578 isoform X1

    UniProtKB/Swiss-Prot
    B4DR51, I3L1Y6, Q96N58

  6. XM_047438193.1 → XP_047294149.1  zinc finger protein 578 isoform X1

    UniProtKB/Swiss-Prot
    B4DR51, I3L1Y6, Q96N58

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55538104..55601470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319851.1 → XP_054175826.1  zinc finger protein 578 isoform X1

  2. XM_054319850.1 → XP_054175825.1  zinc finger protein 578 isoform X1

  3. XM_054319853.1 → XP_054175828.1  zinc finger protein 578 isoform X1

  4. XM_054319852.1 → XP_054175827.1  zinc finger protein 578 isoform X1

  5. XM_054319854.1 → XP_054175829.1  zinc finger protein 578 isoform X1

  6. XM_054319855.1 → XP_054175830.1  zinc finger protein 578 isoform X1

  7. XM_054319856.1 → XP_054175831.1  zinc finger protein 578 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152472.1: Suppressed sequence

    Description
    NM_152472.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1T7F1.1 GenPept UniProtKB/Swiss-Prot:Q1T7F1
Q96N58.2 GenPept UniProtKB/Swiss-Prot:Q96N58

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