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DDX11 DEAD/H-box helicase 11 [ Homo sapiens (human) ]

Gene ID: 1663, updated on 10-Dec-2024

Summary

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Official Symbol
DDX11provided by HGNC
Official Full Name
DEAD/H-box helicase 11provided by HGNC
Primary source
HGNC:HGNC:2736
See related
Ensembl:ENSG00000013573 MIM:601150; AllianceGenome:HGNC:2736
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHL1; KRG2; WABS; CHLR1
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 6.8), lymph node (RPKM 4.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See DDX11 in Genome Data Viewer
Location:
12p11.21
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (31073860..31104799)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (30948354..30979293)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31226794..31257733)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene tetraspanin 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31130578-31131412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31133507-31134008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31134009-31134508 Neighboring gene TSPAN11 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31140539-31141040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31141041-31141540 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:31165500-31165701 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:31181720-31181949 Neighboring gene DDX11 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7044 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:31226445-31226976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:31227509-31228038 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31232984-31233540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31256969-31257468 Neighboring gene MPRA-validated peak1651 silencer Neighboring gene uncharacterized LOC124902912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31270198-31270728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31270729-31271258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31273911-31274440 Neighboring gene alpha-2-macroglobulin like 1 pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31373729-31374473 Neighboring gene uncharacterized LOC107987168

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. DDX11-AS1 contributes to osteosarcoma progression via stabilizing DDX11. Zhang H, et al. Life Sci, 2020 Aug 1. PMID 32014424
  2. LncRNA DDX11-AS1: a novel oncogene in human cancer. Feng Y, et al. Hum Cell, 2020 Oct. PMID 32772230
  3. Warsaw Syndrome. Adam MP, et al. , 1993. PMID 31169992
  4. Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1. van der Lelij P, et al. Am J Hum Genet, 2010 Feb 12. PMID 20137776, Free PMC Article
  5. DDX11-AS1exacerbates bladder cancer progression by enhancing CDK6 expression via suppressing miR-499b-5p. Li Q, et al. Biomed Pharmacother, 2020 Jul. PMID 32422563

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DEAD/H-box helicase 11 is transcriptionally activated by Yin Yang-1 and accelerates oral squamous cell carcinoma progression.
    Title: DEAD/H-box helicase 11 is transcriptionally activated by Yin Yang-1 and accelerates oral squamous cell carcinoma progression.
  2. Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency.
    Title: Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency.
  3. Mutations in DEAD/H-box helicase 11 correlate with increased relapse risk in adults with acute myeloid leukaemia with normal cytogenetics.
    Title: Mutations in DEAD/H-box helicase 11 correlate with increased relapse risk in adults with acute myeloid leukaemia with normal cytogenetics.
  4. Finding underlying genetic mechanisms of two patients with autism spectrum disorder carrying familial apparently balanced chromosomal translocations.
    Title: Finding underlying genetic mechanisms of two patients with autism spectrum disorder carrying familial apparently balanced chromosomal translocations.
  5. Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.
    Title: Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.
  6. Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
    Title: Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
  7. E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway.
    Title: E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway.
  8. The long non-coding RNA DDX11-AS1 facilitates cell progression and oxaliplatin resistance via regulating miR-326/IRS1 axis in gastric cancer.
    Title: The long non-coding RNA DDX11-AS1 facilitates cell progression and oxaliplatin resistance via regulating miR-326/IRS1 axis in gastric cancer.
  9. The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation.
    Title: The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation.
  10. DDX11-AS1exacerbates bladder cancer progression by enhancing CDK6 expression via suppressing miR-499b-5p.
    Title: DDX11-AS1exacerbates bladder cancer progression by enhancing CDK6 expression via suppressing miR-499b-5p.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Warsaw breakage syndrome
MedGen: C3150658 OMIM: 613398 GeneReviews: Warsaw Syndrome
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat DDX11 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
nucleocapsid gag DDX11 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC9335, MGC133249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 5'-3' DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent activity, acting on DNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP-dependent activity, acting on RNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA replication origin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables G-quadruplex DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables forked DNA-dependent helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables four-way junction helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables triplex DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA duplex unwinding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in G-quadruplex DNA unwinding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to bleomycin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to cisplatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hydroxyurea IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleolar chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sister chromatid cohesion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
NOT part_of mitotic cohesin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ATP-dependent DNA helicase DDX11
Names
CHL1-like helicase homolog
CHL1-related helicase gene-1
CHL1-related protein 1
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)
DEAD/H box protein 11
DNA 5'-3' helicase DDX11
KRG-2
hCHLR1
keratinocyte growth factor-regulated gene 2 protein
probable ATP-dependent DNA helicase DDX11
probable ATP-dependent RNA helicase DDX11
NP_001244073.1
NP_001244074.1
NP_001400621.1
NP_001400622.1
NP_001400623.1
NP_001400624.1
NP_001400625.1
NP_001400626.1
NP_001400627.1
NP_001400628.1
NP_001400629.1
NP_001400631.1
NP_001400632.1
NP_001400633.1
NP_001400634.1
NP_001400635.1
NP_004390.3
NP_085911.2
NP_689651.1
XP_005253388.1
XP_005253390.1
XP_006719113.1
XP_011518894.1
XP_011518897.1
XP_011518899.2
XP_016874408.1
XP_016874409.2
XP_016874410.2
XP_016874411.1
XP_016874414.1
XP_016874415.2
XP_016874416.2
XP_016874417.2
XP_016874418.2
XP_016874419.2
XP_016874424.1
XP_016874425.1
XP_016874426.1
XP_016874427.2
XP_016874428.2
XP_047284403.1
XP_047284404.1
XP_047284405.1
XP_047284407.1
XP_047284408.1
XP_047284409.1
XP_047284410.1
XP_047284411.1
XP_047284412.1
XP_047284413.1
XP_047284414.1
XP_047284415.1
XP_047284416.1
XP_047284417.1
XP_047284418.1
XP_047284419.1
XP_047284420.1
XP_047284421.1
XP_054227284.1
XP_054227285.1
XP_054227286.1
XP_054227287.1
XP_054227288.1
XP_054227289.1
XP_054227290.1
XP_054227291.1
XP_054227292.1
XP_054227293.1
XP_054227294.1
XP_054227295.1
XP_054227296.1
XP_054227297.1
XP_054227298.1
XP_054227299.1
XP_054227300.1
XP_054227301.1
XP_054227302.1
XP_054227303.1
XP_054227304.1
XP_054227305.1
XP_054227306.1
XP_054227307.1
XP_054227308.1
XP_054227309.1
XP_054227310.1
XP_054227311.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023352.1 RefSeqGene

    Range
    5016..35955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001257144.2 → NP_001244073.1  ATP-dependent DNA helicase DDX11 isoform 3

    See identical proteins and their annotated locations for NP_001244073.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 3, 4, 9 and 10 all encode the same isoform (3).
    Source sequence(s)
    AC008013, BC050522
    Consensus CDS
    CCDS44856.1
    UniProtKB/Swiss-Prot
    Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999, Q96FC9
    UniProtKB/TrEMBL
    Q2NKM7
    Related
    ENSP00000440402.1, ENST00000545668.5
    Conserved Domains (1) summary
    cl26947
    Location:227 → 822
    HBB; Helical and beta-bridge domain

  2. NM_001257145.2 → NP_001244074.1  ATP-dependent DNA helicase DDX11 isoform 4

    See identical proteins and their annotated locations for NP_001244074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses a downstream AUG compared to variant 3. The resulting protein (isoform 4) has shorter N- and C-termini compared to isoform 3. Variants 5, 11, and 12 all encode the same isoform (4).
    Source sequence(s)
    AC008013, BC050069
    Consensus CDS
    CCDS58224.1
    UniProtKB/TrEMBL
    Q2NKM7
    Related
    ENSP00000228264.6, ENST00000228264.10
    Conserved Domains (3) summary
    smart00488
    Location:1 → 411
    DEXDc2; DEAD-like helicases superfamily
    TIGR00604
    Location:201 → 867
    rad3; DNA repair helicase (rad3)
    pfam13307
    Location:666 → 853
    Helicase_C_2; Helicase C-terminal domain

  3. NM_001413692.1 → NP_001400621.1  ATP-dependent DNA helicase DDX11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/TrEMBL
    Q2NKM7

  4. NM_001413693.1 → NP_001400622.1  ATP-dependent DNA helicase DDX11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/TrEMBL
    Q2NKM7

  5. NM_001413694.1 → NP_001400623.1  ATP-dependent DNA helicase DDX11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/TrEMBL
    Q2NKM7

  6. NM_001413695.1 → NP_001400624.1  ATP-dependent DNA helicase DDX11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/Swiss-Prot
    Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999, Q96FC9
    UniProtKB/TrEMBL
    Q2NKM7

  7. NM_001413696.1 → NP_001400625.1  ATP-dependent DNA helicase DDX11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/Swiss-Prot
    Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999, Q96FC9
    UniProtKB/TrEMBL
    Q2NKM7

  8. NM_001413697.1 → NP_001400626.1  ATP-dependent DNA helicase DDX11 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/TrEMBL
    Q2NKM7

  9. NM_001413698.1 → NP_001400627.1  ATP-dependent DNA helicase DDX11 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/TrEMBL
    Q2NKM7

  10. NM_001413699.1 → NP_001400628.1  ATP-dependent DNA helicase DDX11 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/TrEMBL
    Q2NKM7

  11. NM_001413700.1 → NP_001400629.1  ATP-dependent DNA helicase DDX11 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/TrEMBL
    Q2NKM7

  12. NM_001413702.1 → NP_001400631.1  ATP-dependent DNA helicase DDX11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/TrEMBL
    Q2NKM7

  13. NM_001413703.1 → NP_001400632.1  ATP-dependent DNA helicase DDX11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/TrEMBL
    Q2NKM7

  14. NM_001413704.1 → NP_001400633.1  ATP-dependent DNA helicase DDX11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC008013

  15. NM_001413705.1 → NP_001400634.1  ATP-dependent DNA helicase DDX11 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/TrEMBL
    Q93000

  16. NM_001413706.1 → NP_001400635.1  ATP-dependent DNA helicase DDX11 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC008013
    UniProtKB/TrEMBL
    Q93000

  17. NM_004399.3 → NP_004390.3  ATP-dependent DNA helicase DDX11 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate splice junction compared to variant 3, that results in a frameshift. The resulting isoform (2) lacks an internal segment and has a distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AC008013, BC011264, BC111733, X99583
    Consensus CDS
    CCDS8721.1
    UniProtKB/TrEMBL
    Q2NKM7
    Related
    ENSP00000309965.5, ENST00000350437.8
    Conserved Domains (3) summary
    smart00488
    Location:11 → 437
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:680 → 817
    HELICc2; helicase superfamily c-terminal domain
    TIGR00604
    Location:227 → 843
    rad3; DNA repair helicase (rad3)

  18. NM_030653.4 → NP_085911.2  ATP-dependent DNA helicase DDX11 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate splice junction at a coding exon compared to variant 3, that results in a frameshift. The resulting isoform (1) is shorter and has a distinct C-terminus compared to isoform 3. Variants 1 and 6-8 all encode the same isoform (1).
    Source sequence(s)
    AC008013, BC011264, BC111733
    Consensus CDS
    CCDS41767.1
    UniProtKB/TrEMBL
    Q2NKM7
    Related
    ENSP00000443426.1, ENST00000542838.6
    Conserved Domains (3) summary
    smart00488
    Location:11 → 437
    DEXDc2; DEAD-like helicases superfamily
    TIGR00604
    Location:227 → 893
    rad3; DNA repair helicase (rad3)
    pfam13307
    Location:692 → 879
    Helicase_C_2; Helicase C-terminal domain

  19. NM_152438.2 → NP_689651.1  ATP-dependent DNA helicase DDX11 isoform 3

    See identical proteins and their annotated locations for NP_689651.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3). Variants 3, 4, 9 and 10 all encode the same isoform (3).
    Source sequence(s)
    AC008013, BC011264, BC111733
    Consensus CDS
    CCDS44856.1
    UniProtKB/Swiss-Prot
    Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999, Q96FC9
    UniProtKB/TrEMBL
    Q2NKM7
    Conserved Domains (1) summary
    cl26947
    Location:227 → 822
    HBB; Helical and beta-bridge domain

RNA

  1. NR_182200.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008013

  2. NR_182201.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008013

  3. NR_182202.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008013
    Related
    ENST00000435753.6

  4. NR_182203.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008013
    Related
    ENST00000539049.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    31073860..31104799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018922.2 → XP_016874411.1  ATP-dependent DNA helicase DDX11 isoform X5

  2. XM_017018925.2 → XP_016874414.1  ATP-dependent DNA helicase DDX11 isoform X5

  3. XM_017018919.3 → XP_016874408.1  ATP-dependent DNA helicase DDX11 isoform X1

  4. XM_006719050.5 → XP_006719113.1  ATP-dependent DNA helicase DDX11 isoform X14

    UniProtKB/TrEMBL
    Q2NKM7
    Conserved Domains (3) summary
    smart00488
    Location:47 → 473
    DEXDc2; DEAD-like helicases superfamily
    TIGR00604
    Location:263 → 929
    rad3; DNA repair helicase (rad3)
    pfam13307
    Location:728 → 915
    Helicase_C_2; Helicase C-terminal domain

  5. XM_005253333.5 → XP_005253390.1  ATP-dependent DNA helicase DDX11 isoform X16

    UniProtKB/TrEMBL
    Q2NKM7
    Conserved Domains (3) summary
    smart00488
    Location:47 → 473
    DEXDc2; DEAD-like helicases superfamily
    TIGR00604
    Location:263 → 929
    rad3; DNA repair helicase (rad3)
    pfam13307
    Location:728 → 915
    Helicase_C_2; Helicase C-terminal domain

  6. XM_011520592.4 → XP_011518894.1  ATP-dependent DNA helicase DDX11 isoform X8

    See identical proteins and their annotated locations for XP_011518894.1

    Conserved Domains (2) summary
    smart00488
    Location:47 → 473
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:746 → 860
    HELICc2; helicase superfamily c-terminal domain

  7. XM_005253331.5 → XP_005253388.1  ATP-dependent DNA helicase DDX11 isoform X12

    UniProtKB/TrEMBL
    Q2NKM7
    Conserved Domains (2) summary
    smart00488
    Location:47 → 473
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:746 → 860
    HELICc2; helicase superfamily c-terminal domain

  8. XM_011520595.4 → XP_011518897.1  ATP-dependent DNA helicase DDX11 isoform X22

    UniProtKB/TrEMBL
    Q2NKM7
    Conserved Domains (3) summary
    smart00488
    Location:47 → 473
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:716 → 853
    HELICc2; helicase superfamily c-terminal domain
    TIGR00604
    Location:263 → 879
    rad3; DNA repair helicase (rad3)

  9. XM_047428447.1 → XP_047284403.1  ATP-dependent DNA helicase DDX11 isoform X2

  10. XM_047428452.1 → XP_047284408.1  ATP-dependent DNA helicase DDX11 isoform X15

    UniProtKB/TrEMBL
    Q2NKM7

  11. XM_047428454.1 → XP_047284410.1  ATP-dependent DNA helicase DDX11 isoform X17

    UniProtKB/TrEMBL
    Q2NKM7

  12. XM_047428448.1 → XP_047284404.1  ATP-dependent DNA helicase DDX11 isoform X10

    UniProtKB/TrEMBL
    Q2NKM7

  13. XM_047428461.1 → XP_047284417.1  ATP-dependent DNA helicase DDX11 isoform X24

    UniProtKB/TrEMBL
    Q2NKM7

  14. XM_047428451.1 → XP_047284407.1  ATP-dependent DNA helicase DDX11 isoform X14

    UniProtKB/TrEMBL
    Q2NKM7

  15. XM_047428453.1 → XP_047284409.1  ATP-dependent DNA helicase DDX11 isoform X16

    UniProtKB/TrEMBL
    Q2NKM7

  16. XM_047428449.1 → XP_047284405.1  ATP-dependent DNA helicase DDX11 isoform X12

    UniProtKB/TrEMBL
    Q2NKM7

  17. XM_047428459.1 → XP_047284415.1  ATP-dependent DNA helicase DDX11 isoform X22

    UniProtKB/TrEMBL
    Q2NKM7

  18. XM_017018928.3 → XP_016874417.2  ATP-dependent DNA helicase DDX11 isoform X9

    UniProtKB/TrEMBL
    Q2NKM7

  19. XM_017018930.3 → XP_016874419.2  ATP-dependent DNA helicase DDX11 isoform X13

    UniProtKB/TrEMBL
    Q2NKM7

  20. XM_017018921.3 → XP_016874410.2  ATP-dependent DNA helicase DDX11 isoform X4

  21. XM_047428455.1 → XP_047284411.1  ATP-dependent DNA helicase DDX11 isoform X18

    UniProtKB/TrEMBL
    Q2NKM7

  22. XM_017018929.3 → XP_016874418.2  ATP-dependent DNA helicase DDX11 isoform X11

    UniProtKB/TrEMBL
    Q2NKM7

  23. XM_017018920.3 → XP_016874409.2  ATP-dependent DNA helicase DDX11 isoform X3

  24. XM_047428457.1 → XP_047284413.1  ATP-dependent DNA helicase DDX11 isoform X20

    UniProtKB/TrEMBL
    Q2NKM7

  25. XM_017018926.3 → XP_016874415.2  ATP-dependent DNA helicase DDX11 isoform X6

  26. XM_017018927.3 → XP_016874416.2  ATP-dependent DNA helicase DDX11 isoform X7

  27. XM_047428460.1 → XP_047284416.1  ATP-dependent DNA helicase DDX11 isoform X23

    UniProtKB/TrEMBL
    Q2NKM7

  28. XM_047428456.1 → XP_047284412.1  ATP-dependent DNA helicase DDX11 isoform X19

    UniProtKB/TrEMBL
    Q2NKM7

  29. XM_047428458.1 → XP_047284414.1  ATP-dependent DNA helicase DDX11 isoform X21

    UniProtKB/TrEMBL
    Q2NKM7

  30. XM_017018938.3 → XP_016874427.2  ATP-dependent DNA helicase DDX11 isoform X28

  31. XM_017018939.3 → XP_016874428.2  ATP-dependent DNA helicase DDX11 isoform X29

  32. XM_047428463.1 → XP_047284419.1  ATP-dependent DNA helicase DDX11 isoform X27

  33. XM_047428464.1 → XP_047284420.1  ATP-dependent DNA helicase DDX11 isoform X30

  34. XM_011520597.4 → XP_011518899.2  ATP-dependent DNA helicase DDX11 isoform X31

  35. XM_017018935.1 → XP_016874424.1  ATP-dependent DNA helicase DDX11 isoform X26

  36. XM_047428462.1 → XP_047284418.1  ATP-dependent DNA helicase DDX11 isoform X25

  37. XM_017018936.1 → XP_016874425.1  ATP-dependent DNA helicase DDX11 isoform X26

  38. XM_047428465.1 → XP_047284421.1  ATP-dependent DNA helicase DDX11 isoform X32

  39. XM_017018937.2 → XP_016874426.1  ATP-dependent DNA helicase DDX11 isoform X26

RNA

  1. XR_001748610.3 RNA Sequence

  2. XR_007063056.1 RNA Sequence

  3. XR_007063057.1 RNA Sequence

  4. XR_007063058.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    30948354..30979293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371328.1 → XP_054227303.1  ATP-dependent DNA helicase DDX11 isoform X34

    UniProtKB/TrEMBL
    Q2NKM7

  2. XM_054371309.1 → XP_054227284.1  ATP-dependent DNA helicase DDX11 isoform X8

  3. XM_054371311.1 → XP_054227286.1  ATP-dependent DNA helicase DDX11 isoform X10

    UniProtKB/TrEMBL
    Q2NKM7

  4. XM_054371310.1 → XP_054227285.1  ATP-dependent DNA helicase DDX11 isoform X8

  5. XM_054371317.1 → XP_054227292.1  ATP-dependent DNA helicase DDX11 isoform X14

    UniProtKB/TrEMBL
    Q2NKM7

  6. XM_054371319.1 → XP_054227294.1  ATP-dependent DNA helicase DDX11 isoform X15

    UniProtKB/TrEMBL
    Q2NKM7

  7. XM_054371325.1 → XP_054227300.1  ATP-dependent DNA helicase DDX11 isoform X24

    UniProtKB/TrEMBL
    Q2NKM7

  8. XM_054371318.1 → XP_054227293.1  ATP-dependent DNA helicase DDX11 isoform X14

    UniProtKB/TrEMBL
    Q2NKM7

  9. XM_054371313.1 → XP_054227288.1  ATP-dependent DNA helicase DDX11 isoform X12

    UniProtKB/TrEMBL
    Q2NKM7

  10. XM_054371314.1 → XP_054227289.1  ATP-dependent DNA helicase DDX11 isoform X12

    UniProtKB/TrEMBL
    Q2NKM7

  11. XM_054371321.1 → XP_054227296.1  ATP-dependent DNA helicase DDX11 isoform X16

    UniProtKB/TrEMBL
    Q2NKM7

  12. XM_054371323.1 → XP_054227298.1  ATP-dependent DNA helicase DDX11 isoform X17

    UniProtKB/TrEMBL
    Q2NKM7

  13. XM_054371322.1 → XP_054227297.1  ATP-dependent DNA helicase DDX11 isoform X16

    UniProtKB/TrEMBL
    Q2NKM7

  14. XM_054371315.1 → XP_054227290.1  ATP-dependent DNA helicase DDX11 isoform X34

    UniProtKB/TrEMBL
    Q2NKM7

  15. XM_054371330.1 → XP_054227305.1  ATP-dependent DNA helicase DDX11 isoform X41

  16. XM_054371320.1 → XP_054227295.1  ATP-dependent DNA helicase DDX11 isoform X36

    UniProtKB/TrEMBL
    Q2NKM7

  17. XM_054371312.1 → XP_054227287.1  ATP-dependent DNA helicase DDX11 isoform X33

  18. XM_054371316.1 → XP_054227291.1  ATP-dependent DNA helicase DDX11 isoform X35

  19. XM_054371331.1 → XP_054227306.1  ATP-dependent DNA helicase DDX11 isoform X42

  20. XM_054371324.1 → XP_054227299.1  ATP-dependent DNA helicase DDX11 isoform X37

    UniProtKB/TrEMBL
    Q2NKM7

  21. XM_054371326.1 → XP_054227301.1  ATP-dependent DNA helicase DDX11 isoform X38

    UniProtKB/TrEMBL
    Q2NKM7

  22. XM_054371327.1 → XP_054227302.1  ATP-dependent DNA helicase DDX11 isoform X39

    UniProtKB/TrEMBL
    Q2NKM7

  23. XM_054371335.1 → XP_054227310.1  ATP-dependent DNA helicase DDX11 isoform X44

  24. XM_054371332.1 → XP_054227307.1  ATP-dependent DNA helicase DDX11 isoform X43

  25. XM_054371329.1 → XP_054227304.1  ATP-dependent DNA helicase DDX11 isoform X40

  26. XM_054371336.1 → XP_054227311.1  ATP-dependent DNA helicase DDX11 isoform X32

  27. XM_054371334.1 → XP_054227309.1  ATP-dependent DNA helicase DDX11 isoform X43

  28. XM_054371333.1 → XP_054227308.1  ATP-dependent DNA helicase DDX11 isoform X43

RNA

  1. XR_008488549.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030655.2: Suppressed sequence

    Description
    NM_030655.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96FC9.1 GenPept UniProtKB/Swiss-Prot:Q96FC9

Gene LinkOut

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