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Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric [ Mus musculus (house mouse) ]

Gene ID: 17833, updated on 9-Dec-2024

Summary

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Official Symbol
Muc5acprovided by MGI
Official Full Name
mucin 5, subtypes A and C, tracheobronchial/gastricprovided by MGI
Primary source
MGI:MGI:104697
See related
Ensembl:ENSMUSG00000037974 AllianceGenome:MGI:104697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MGM; 2210005L13Rik
Summary
Acts upstream of or within maintenance of lens transparency. Located in extracellular space. Is expressed in male reproductive gland or organ; nasal cavity epithelium; respiratory system; and stomach. Used to study dry eye syndrome. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and dry eye syndrome. Orthologous to human MUC5AC (mucin 5AC, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward stomach adult (RPKM 445.3) See more
Orthologs
human all
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Genomic context

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See Muc5ac in Genome Data Viewer
Location:
7 F5; 7 87.23 cM
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141342695..141372964)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141788958..141819227)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex 2, alpha 2 subunit Neighboring gene mucin 6, gastric Neighboring gene mucin 2 Neighboring gene STARR-seq mESC enhancer starr_20496 Neighboring gene mucin 5, subtype B, tracheobronchial Neighboring gene toll interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Complement C3a regulates Muc5ac expression by airway Clara cells independently of Th2 responses. Dillard P, et al. Am J Respir Crit Care Med, 2007 Jun 15. PMID 17400733, Free PMC Article
  2. Protective role of overexpressed MUC5AC against fibrosis in MHV-68-induced combined pulmonary fibrosis and emphysema mouse model. He L, et al. J Med Virol, 2020 Dec. PMID 32557739
  3. A nanomedicine to treat ocular surface inflammation: performance on an experimental dry eye murine model. Contreras-Ruiz L, et al. Gene Ther, 2013 May. PMID 22809996
  4. Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs. Ehre C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012413, Free PMC Article
  5. Disulfide disruption reverses mucus dysfunction in allergic airway disease. Morgan LE, et al. Nat Commun, 2021 Jan 11. PMID 33431872, Free PMC Article

See all (135) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protective role of overexpressed MUC5AC against fibrosis in MHV-68-induced combined pulmonary fibrosis and emphysema mouse model.
    Title: Protective role of overexpressed MUC5AC against fibrosis in MHV-68-induced combined pulmonary fibrosis and emphysema mouse model.
  2. House dust mite-induced endoplasmic reticulum stress mediates MUC5AC hypersecretion via TBK1 in airway epithelium.
    Title: House dust mite-induced endoplasmic reticulum stress mediates MUC5AC hypersecretion via TBK1 in airway epithelium.
  3. [Dickkopf-1 inhibits the secretion of MUC5AC induced by Mycoplasma pneumoniae P1-C in mouse lung epithelial cells].
    Title: [Dickkopf-1 inhibits the secretion of MUC5AC induced by Mycoplasma pneumoniae P1-C in mouse lung epithelial cells].
  4. De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.
    Title: De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.
  5. Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
    Title: Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
  6. Mucin 5AC-Mediated CD44/ITGB1 Clustering Mobilizes Adipose-Derived Mesenchymal Stem Cells to Modulate Pancreatic Cancer Stromal Heterogeneity.
    Title: Mucin 5AC-Mediated CD44/ITGB1 Clustering Mobilizes Adipose-Derived Mesenchymal Stem Cells to Modulate Pancreatic Cancer Stromal Heterogeneity.
  7. Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease.
    Title: Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease.
  8. Mucin 5AC Serves as the Nexus for beta-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance.
    Title: Mucin 5AC Serves as the Nexus for β-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance.
  9. Porphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells.
    Title: Porphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells.
  10. Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.
    Title: Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.
Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within maintenance of lens transparency IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in mucus layer ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mucin-5AC
Names
gastric mucin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010844.3 → NP_034974.2  mucin-5AC precursor

    Status: VALIDATED

    Source sequence(s)
    AC175658, AC175742
    UniProtKB/TrEMBL
    E9QAQ8
    Conserved Domains (8) summary
    PHA02682
    Location:3007 → 3157
    PHA02682; ORF080 virion core protein; Provisional
    smart00041
    Location:3339 → 3411
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00216
    Location:890 → 1049
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:622 → 692
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:2052 → 2254
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01826
    Location:337 → 393
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:265 → 333
    C8; C8 domain
    pfam13330
    Location:1605 → 1691
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141342695..141372964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508499.2 → XP_006508562.1  mucin-5AC isoform X1

    UniProtKB/TrEMBL
    E9QAQ8
    Related
    ENSMUSP00000122353.4, ENSMUST00000155534.9
    Conserved Domains (8) summary
    PHA02682
    Location:3012 → 3162
    PHA02682; ORF080 virion core protein; Provisional
    smart00041
    Location:3344 → 3416
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00216
    Location:895 → 1054
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:627 → 697
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:2057 → 2259
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01826
    Location:341 → 397
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:269 → 337
    C8; C8 domain
    pfam13330
    Location:1610 → 1696
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region

  2. XM_006508500.2 → XP_006508563.1  mucin-5AC isoform X2

    UniProtKB/TrEMBL
    E9QAQ8
    Related
    ENSMUSP00000039699.8, ENSMUST00000041924.14
    Conserved Domains (8) summary
    PHA02682
    Location:2980 → 3130
    PHA02682; ORF080 virion core protein; Provisional
    smart00041
    Location:3312 → 3384
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00216
    Location:895 → 1054
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:627 → 697
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:1869 → 2227
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01826
    Location:341 → 397
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:269 → 337
    C8; C8 domain
    pfam13330
    Location:1610 → 1696
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
Nucleotide Protein Strain
Heading Accession and Version

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