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Zfp871 zinc finger protein 871 [ Mus musculus (house mouse) ]

Gene ID: 208292, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp871provided by MGI
Official Full Name
zinc finger protein 871provided by MGI
Primary source
MGI:MGI:1921793
See related
Ensembl:ENSMUSG00000024298 AllianceGenome:MGI:1921793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA3006; 4732483N19; 9030612M13Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; cardiovascular system; and genitourinary system. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 9.8), limb E14.5 (RPKM 9.8) and 28 other tissues See more
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Genomic context

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See Zfp871 in Genome Data Viewer
Location:
17 B1; 17 17.93 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32984470..33007261, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32765496..32788287, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene non-SMC element 1 homolog pseudogene Neighboring gene ets variant gene 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42394 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32925111-32925412 Neighboring gene predicted gene 17115 Neighboring gene zinc finger protein 811 Neighboring gene predicted gene, 23294

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice Deficient in the RNA-Binding Protein Zfp871 Are Prone to Early Death and Steatohepatitis in Part through the p53-Mdm2 Axis. Mohibi S, et al. Mol Cancer Res, 2021 Oct. PMID 34257081, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mice Deficient in the RNA-Binding Protein Zfp871 Are Prone to Early Death and Steatohepatitis in Part through the p53-Mdm2 Axis.
    Title: Mice Deficient in the RNA-Binding Protein Zfp871 Are Prone to Early Death and Steatohepatitis in Part through the p53-Mdm2 Axis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 871

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346705.1 → NP_001333634.1  zinc finger protein 871 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT485613
    Consensus CDS
    CCDS84294.1
    UniProtKB/TrEMBL
    Q80XN4
    Related
    ENSMUSP00000050501.9, ENSMUST00000057501.9

  2. NM_172458.3 → NP_766046.3  zinc finger protein 871 isoform 1

    See identical proteins and their annotated locations for NP_766046.3

    Status: VALIDATED

    Source sequence(s)
    AI119099, AK079746, AK122579, AK141605, BE198070, CAAA01124964
    Consensus CDS
    CCDS50061.1
    UniProtKB/TrEMBL
    G5E905
    Related
    ENSMUSP00000127178.2, ENSMUST00000159086.10
    Conserved Domains (5) summary
    smart00349
    Location:4 → 44
    KRAB; krueppel associated box
    COG5048
    Location:217 → 553
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:363 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:375 → 400
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    32984470..33007261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160429.1 → XP_036016322.1  zinc finger protein 871 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:75 → 411
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:369 → 461
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:221 → 241
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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