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Tenm2 teneurin transmembrane protein 2 [ Mus musculus (house mouse) ]

Gene ID: 23964, updated on 11-Jun-2024

Summary

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Official Symbol
Tenm2provided by MGI
Official Full Name
teneurin transmembrane protein 2provided by MGI
Primary source
MGI:MGI:1345184
See related
Ensembl:ENSMUSG00000049336 AllianceGenome:MGI:1345184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Odz2; Odz3; Ten-2; Ten-m2
Summary
Enables protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in several processes, including calcium-mediated signaling using intracellular calcium source; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and retrograde trans-synaptic signaling by trans-synaptic protein complex. Predicted to act upstream of or within cell adhesion. Predicted to be located in cell-cell junction; dendritic spine; and postsynaptic membrane. Predicted to be integral component of plasma membrane. Predicted to be active in neuron projection. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and skeleton. Orthologous to human TENM2 (teneurin transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 3.0), whole brain E14.5 (RPKM 2.9) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Tenm2 in Genome Data Viewer
Location:
11 A4- A5; 11 21.96 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (35897483..37881486, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (36006656..37237053, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9361 Neighboring gene STARR-positive B cell enhancer ABC_E6965 Neighboring gene STARR-seq mESC enhancer starr_29194 Neighboring gene STARR-seq mESC enhancer starr_29197 Neighboring gene arginyl-tRNA synthetase 1 Neighboring gene WW, C2 and coiled-coil domain containing 1 Neighboring gene predicted gene, 42072 Neighboring gene STARR-seq mESC enhancer starr_29200 Neighboring gene predicted gene 12126 Neighboring gene predicted gene, 42071 Neighboring gene predicted gene, 46251 Neighboring gene predicted gene, 33585 Neighboring gene STARR-seq mESC enhancer starr_29205 Neighboring gene STARR-seq mESC enhancer starr_29206 Neighboring gene predicted gene, 51889 Neighboring gene predicted gene, 22127 Neighboring gene predicted gene, 53696 Neighboring gene predicted gene, 51890 Neighboring gene STARR-seq mESC enhancer starr_29209 Neighboring gene predicted gene, 53695 Neighboring gene STARR-seq mESC enhancer starr_29211 Neighboring gene predicted gene, 33791 Neighboring gene predicted gene 12128 Neighboring gene STARR-seq mESC enhancer starr_29212 Neighboring gene STARR-seq mESC enhancer starr_29213 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene 12130

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Teneurins: a novel family of neuronal cell surface proteins in vertebrates, homologous to the Drosophila pair-rule gene product Ten-m. Rubin BP, et al. Dev Biol, 1999 Dec 1. PMID 10588872
  2. Ten-m2 is required for the generation of binocular visual circuits. Young TR, et al. J Neurosci, 2013 Jul 24. PMID 23884953, Free PMC Article
  3. Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues. Oohashi T, et al. J Cell Biol, 1999 May 3. PMID 10225957, Free PMC Article
  4. Genomic response to Wnt signalling is highly context-dependent--evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt/TCF targets. Railo A, et al. Exp Cell Res, 2009 Oct 1. PMID 19563800
  5. The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain. Zhou XH, et al. Gene Expr Patterns, 2003 Aug. PMID 12915301

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA1127, D3Bwg1534e, 2610040L17Rik, 9330187F13Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in extrinsic component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
teneurin-2
Names
odd Oz/ten-m homolog 2
protein Odd Oz/ten-m homolog 2
tenascin-M2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290702.1 → NP_001277631.1  teneurin-2 isoform 2

    See identical proteins and their annotated locations for NP_001277631.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AL645912, AL713915, AL713919, AL713956, BX000433, BX539311
    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    UniProtKB/TrEMBL
    B9EJ72
    Conserved Domains (8) summary
    COG3209
    Location:1648 → 2441
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1199 → 1238
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2350 → 2427
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:539 → 561
    EGF_2; EGF-like domain
    cl18310
    Location:1199 → 1529
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:626 → 744
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2649 → 2726
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  2. NM_011856.4 → NP_035986.3  teneurin-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL645912, AL713915, AL713919, AL713956, BX000433, BX539311
    Consensus CDS
    CCDS24546.1
    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    UniProtKB/TrEMBL
    A0A0A0MQB7
    Related
    ENSMUSP00000129951.2, ENSMUST00000163524.8
    Conserved Domains (10) summary
    COG3209
    Location:1679 → 2472
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:671 → 700
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:1230 → 1269
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2381 → 2458
    Rhs_assc_core; RHS repeat-associated core domain
    pfam05593
    Location:1672 → 1710
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:580 → 602
    EGF_2; EGF-like domain
    pfam15636
    Location:2682 → 2757
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1230 → 1560
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:725 → 764
    DSL; Delta serrate ligand

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    35897483..37881486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156687.1 → XP_036012580.1  teneurin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1689 → 2482
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1240 → 1279
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2391 → 2468
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1240 → 1570
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2690 → 2767
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:570 → 885
    exchanger_TraA; outer membrane exchange protein TraA

  2. XM_006533290.4 → XP_006533353.1  teneurin-2 isoform X1

    See identical proteins and their annotated locations for XP_006533353.1

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1689 → 2482
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1240 → 1279
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2391 → 2468
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1240 → 1570
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2690 → 2767
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:570 → 885
    exchanger_TraA; outer membrane exchange protein TraA

  3. XM_030245994.1 → XP_030101854.1  teneurin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1689 → 2482
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1240 → 1279
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2391 → 2468
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1240 → 1570
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2690 → 2767
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:570 → 885
    exchanger_TraA; outer membrane exchange protein TraA

  4. XM_036156689.1 → XP_036012582.1  teneurin-2 isoform X10

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1578 → 2371
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1129 → 1168
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2280 → 2357
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1129 → 1459
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 304
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2579 → 2656
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:459 → 774
    exchanger_TraA; outer membrane exchange protein TraA

  5. XM_036156690.1 → XP_036012583.1  teneurin-2 isoform X11

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (8) summary
    COG3209
    Location:1548 → 2341
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1099 → 1138
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2250 → 2327
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1099 → 1429
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 304
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2549 → 2626
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033662
    Location:702 → 732
    acid_disulf_rpt; acidic double-disulfide repeat
    NF033759
    Location:500 → 738
    exchanger_TraA; outer membrane exchange protein TraA

  6. XM_006533295.4 → XP_006533358.1  teneurin-2 isoform X7

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (8) summary
    COG3209
    Location:1619 → 2412
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1170 → 1209
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2321 → 2398
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:510 → 532
    EGF_2; EGF-like domain
    cl18310
    Location:1170 → 1500
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:597 → 715
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10 → 304
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2620 → 2697
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  7. XM_011249009.3 → XP_011247311.1  teneurin-2 isoform X6

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (8) summary
    COG3209
    Location:1641 → 2434
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1199 → 1227
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2343 → 2420
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:539 → 561
    EGF_2; EGF-like domain
    cl18310
    Location:1199 → 1522
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:626 → 744
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2642 → 2719
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  8. XM_006533287.4 → XP_006533350.1  teneurin-2 isoform X1

    See identical proteins and their annotated locations for XP_006533350.1

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1689 → 2482
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1240 → 1279
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2391 → 2468
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1240 → 1570
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2690 → 2767
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:570 → 885
    exchanger_TraA; outer membrane exchange protein TraA

  9. XM_006533288.4 → XP_006533351.1  teneurin-2 isoform X1

    See identical proteins and their annotated locations for XP_006533351.1

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1689 → 2482
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1240 → 1279
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2391 → 2468
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1240 → 1570
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2690 → 2767
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:570 → 885
    exchanger_TraA; outer membrane exchange protein TraA

  10. XM_030245995.2 → XP_030101855.1  teneurin-2 isoform X9

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (10) summary
    COG3209
    Location:1611 → 2404
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:671 → 700
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:1169 → 1197
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2313 → 2390
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:576 → 602
    EGF_2; EGF-like domain
    cl18310
    Location:1169 → 1492
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:667 → 803
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2612 → 2689
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    pfam18372
    Location:611 → 628
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  11. XM_006533296.5 → XP_006533359.1  teneurin-2 isoform X8

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (10) summary
    COG3209
    Location:1618 → 2411
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:671 → 700
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:1169 → 1208
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2320 → 2397
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:576 → 602
    EGF_2; EGF-like domain
    cl18310
    Location:1169 → 1499
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:667 → 803
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2619 → 2696
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    pfam18372
    Location:611 → 628
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  12. XM_006533293.5 → XP_006533356.1  teneurin-2 isoform X4

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (9) summary
    COG3209
    Location:1673 → 2466
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:798 → 831
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:1231 → 1259
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2375 → 2452
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:580 → 602
    EGF_2; EGF-like domain
    cl18310
    Location:1231 → 1554
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:667 → 785
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2674 → 2751
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  13. XM_006533292.5 → XP_006533355.1  teneurin-2 isoform X3

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    UniProtKB/TrEMBL
    A0A0A0MQ92
    Related
    ENSMUSP00000052014.6, ENSMUST00000057207.6
    Conserved Domains (9) summary
    COG3209
    Location:1680 → 2473
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:798 → 831
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:1231 → 1270
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2382 → 2459
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:580 → 602
    EGF_2; EGF-like domain
    cl18310
    Location:1231 → 1561
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:667 → 785
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2681 → 2758
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  14. XM_006533291.5 → XP_006533354.1  teneurin-2 isoform X2

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (8) summary
    COG3209
    Location:1682 → 2475
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1240 → 1268
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2384 → 2461
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:580 → 602
    EGF_2; EGF-like domain
    cl18310
    Location:1240 → 1563
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:667 → 785
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2683 → 2760
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  15. XM_006533289.2 → XP_006533352.1  teneurin-2 isoform X1

    See identical proteins and their annotated locations for XP_006533352.1

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1689 → 2482
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1240 → 1279
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2391 → 2468
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1240 → 1570
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2690 → 2767
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:570 → 885
    exchanger_TraA; outer membrane exchange protein TraA

  16. XM_036156688.1 → XP_036012581.1  teneurin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1689 → 2482
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1240 → 1279
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2391 → 2468
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1240 → 1570
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2690 → 2767
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:570 → 885
    exchanger_TraA; outer membrane exchange protein TraA

  17. XM_036156696.1 → XP_036012589.1  teneurin-2 isoform X21

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1426 → 2219
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:977 → 1016
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2128 → 2205
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:977 → 1307
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:14 → 152
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2427 → 2504
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:307 → 622
    exchanger_TraA; outer membrane exchange protein TraA

  18. XM_036156698.1 → XP_036012591.1  teneurin-2 isoform X24

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (8) summary
    COG3209
    Location:1396 → 2189
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:947 → 986
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2098 → 2175
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:947 → 1277
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:14 → 152
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2397 → 2474
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033662
    Location:550 → 580
    acid_disulf_rpt; acidic double-disulfide repeat
    NF033759
    Location:348 → 586
    exchanger_TraA; outer membrane exchange protein TraA

  19. XM_006533301.5 → XP_006533364.1  teneurin-2 isoform X19

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (8) summary
    COG3209
    Location:1467 → 2260
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1018 → 1057
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2169 → 2246
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:358 → 380
    EGF_2; EGF-like domain
    cl18310
    Location:1018 → 1348
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:445 → 563
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10 → 152
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2468 → 2545
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  20. XM_036156697.1 → XP_036012590.1  teneurin-2 isoform X22

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (8) summary
    COG3209
    Location:1425 → 2218
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:976 → 1015
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2127 → 2204
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:976 → 1306
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 222
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2426 → 2503
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033662
    Location:579 → 609
    acid_disulf_rpt; acidic double-disulfide repeat
    NF033759
    Location:377 → 615
    exchanger_TraA; outer membrane exchange protein TraA

  21. XM_036156694.1 → XP_036012587.1  teneurin-2 isoform X18

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1487 → 2280
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1038 → 1077
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2189 → 2266
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1038 → 1368
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 222
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2488 → 2565
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:377 → 683
    exchanger_TraA; outer membrane exchange protein TraA

  22. XM_036156693.1 → XP_036012586.1  teneurin-2 isoform X16

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1496 → 2289
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1047 → 1086
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2198 → 2275
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1047 → 1377
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 222
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2497 → 2574
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:377 → 692
    exchanger_TraA; outer membrane exchange protein TraA

  23. XM_036156695.1 → XP_036012588.1  teneurin-2 isoform X20

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (8) summary
    COG3209
    Location:1466 → 2259
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1017 → 1056
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2168 → 2245
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1017 → 1347
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 222
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2467 → 2544
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033662
    Location:620 → 650
    acid_disulf_rpt; acidic double-disulfide repeat
    NF033759
    Location:418 → 656
    exchanger_TraA; outer membrane exchange protein TraA

  24. XM_036156692.1 → XP_036012585.1  teneurin-2 isoform X14

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1528 → 2321
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1079 → 1118
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2230 → 2307
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1079 → 1409
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 222
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2529 → 2606
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:418 → 724
    exchanger_TraA; outer membrane exchange protein TraA

  25. XM_036156691.1 → XP_036012584.1  teneurin-2 isoform X13

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (7) summary
    COG3209
    Location:1530 → 2323
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1088 → 1116
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2232 → 2309
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1088 → 1411
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:10 → 222
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2531 → 2608
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:418 → 733
    exchanger_TraA; outer membrane exchange protein TraA

  26. XM_006533297.5 → XP_006533360.1  teneurin-2 isoform X12

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (8) summary
    COG3209
    Location:1537 → 2330
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1088 → 1127
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2239 → 2316
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:428 → 450
    EGF_2; EGF-like domain
    cl18310
    Location:1088 → 1418
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:515 → 633
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10 → 222
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2538 → 2615
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  27. XM_030245996.2 → XP_030101856.1  teneurin-2 isoform X23

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (10) summary
    COG3209
    Location:1421 → 2214
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:474 → 503
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:972 → 1011
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2123 → 2200
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:379 → 405
    EGF_2; EGF-like domain
    cl18310
    Location:972 → 1302
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:470 → 606
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:1 → 177
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2422 → 2499
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    pfam18372
    Location:414 → 431
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

  28. XM_017314549.2 → XP_017170038.1  teneurin-2 isoform X17

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (8) summary
    COG3209
    Location:1492 → 2285
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1043 → 1082
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2194 → 2271
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:383 → 405
    EGF_2; EGF-like domain
    cl18310
    Location:1043 → 1373
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:470 → 588
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:1 → 177
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2493 → 2570
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  29. XM_017314548.2 → XP_017170037.1  teneurin-2 isoform X17

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (8) summary
    COG3209
    Location:1492 → 2285
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1043 → 1082
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2194 → 2271
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:383 → 405
    EGF_2; EGF-like domain
    cl18310
    Location:1043 → 1373
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:470 → 588
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:1 → 177
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2493 → 2570
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  30. XM_006533298.3 → XP_006533361.1  teneurin-2 isoform X15

    See identical proteins and their annotated locations for XP_006533361.1

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    Conserved Domains (8) summary
    COG3209
    Location:1527 → 2320
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1078 → 1117
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2229 → 2306
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:418 → 440
    EGF_2; EGF-like domain
    cl18310
    Location:1078 → 1408
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:505 → 623
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:4 → 212
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2528 → 2605
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  31. XM_006533294.5 → XP_006533357.1  teneurin-2 isoform X5

    See identical proteins and their annotated locations for XP_006533357.1

    UniProtKB/Swiss-Prot
    Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
    UniProtKB/TrEMBL
    B9EJ72
    Conserved Domains (8) summary
    COG3209
    Location:1648 → 2441
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1199 → 1238
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2350 → 2427
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:539 → 561
    EGF_2; EGF-like domain
    cl18310
    Location:1199 → 1529
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01500
    Location:626 → 744
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2649 → 2726
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTS5.1 GenPept UniProtKB/Swiss-Prot:Q9WTS5

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