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TAB3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [ Homo sapiens (human) ]

Gene ID: 257397, updated on 3-Nov-2024

Summary

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Official Symbol
TAB3provided by HGNC
Official Full Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 3provided by HGNC
Primary source
HGNC:HGNC:30681
See related
Ensembl:ENSG00000157625 MIM:300480; AllianceGenome:HGNC:30681
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAP1; MAP3K7IP3
Summary
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 6.3), endometrium (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

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See TAB3 in Genome Data Viewer
Location:
Xp21.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (30827442..30889254, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (30425653..30487452, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (30845559..30907371, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:30771431-30772154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:30813295-30813854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20726 Neighboring gene myoneurin pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29510 Neighboring gene GK antisense RNA 1 Neighboring gene TAB3 antisense RNA 1 Neighboring gene glycerol kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29513 Neighboring gene Sharpr-MPRA regulatory region 11226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29516 Neighboring gene Sharpr-MPRA regulatory region 5644 Neighboring gene ferritin heavy chain like 17 Neighboring gene dystrophin Neighboring gene RNA, U6 small nuclear 894, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TAB3 overexpression promotes cell proliferation in non-small cell lung cancer and mediates chemoresistance to CDDP in A549 cells via the NF-κB pathway. Chen J, et al. Tumour Biol, 2016 Mar. PMID 26476534
  2. Identification of a human NF-kappaB-activating protein, TAB3. Jin G, et al. Proc Natl Acad Sci U S A, 2004 Feb 17. PMID 14766965, Free PMC Article
  3. Loss of TAB3 expression by shRNA exhibits suppressive bioactivity and increased chemical sensitivity of ovarian cancer cell lines via the NF-κB pathway. Chen Y, et al. Cell Prolif, 2016 Dec. PMID 27651027, Free PMC Article
  4. Evidence for a Role of TGF-β-Activated Kinase 1 and MAP3K7 Binding Protein 3 in Peanut-Specific T-Cell Responses. Saidova A, et al. Int Arch Allergy Immunol, 2019. PMID 30893695
  5. TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway. Zhao J, et al. Oncol Rep, 2018 Nov. PMID 30226617

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-27a-3p upregulation by p65 facilitates cervical tumorigenesis by increasing TAB3 expression and is involved in the positive feedback loop of NF-kappaB signaling.
    Title: miR‑27a‑3p upregulation by p65 facilitates cervical tumorigenesis by increasing TAB3 expression and is involved in the positive feedback loop of NF‑κB signaling.
  2. ZEB2-AS1 regulates the expression of TAB3 and promotes the development of colon cancer by adsorbing microRNA-188.
    Title: ZEB2-AS1 regulates the expression of TAB3 and promotes the development of colon cancer by adsorbing microRNA-188.
  3. Neddylation promotes protein translocation between the cytoplasm and nucleus.
    Title: Neddylation promotes protein translocation between the cytoplasm and nucleus.
  4. TAB3 upregulates PIM1 expression by directly activating the TAK1-STAT3 complex to promote colorectal cancer growth.
    Title: TAB3 upregulates PIM1 expression by directly activating the TAK1-STAT3 complex to promote colorectal cancer growth.
  5. multiple GPCR agonists utilize non-canonical TAB1-TAB2 and TAB1-TAB3-dependent p38 activation to promote endothelial inflammatory responses.
    Title: G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells.
  6. TAB3 may play a significant role at the level of T-cell activation and may also be a candidate biomarker for peanut allergy.
    Title: Evidence for a Role of TGF-β-Activated Kinase 1 and MAP3K7 Binding Protein 3 in Peanut-Specific T-Cell Responses.
  7. these results demonstrated that TAB3 may be a promising therapeutic target for the treatment of Esophageal squamous cell carcinoma.
    Title: TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway.
  8. The combination of WES, genomic triangulation, and systems biology has uncovered perturbations in TGF-beta activated kinase 1 signaling as a novel pathogenic substrate for polyvalvular syndrome.
    Title: Whole Exome Sequencing, Familial Genomic Triangulation, and Systems Biology Converge to Identify a Novel Nonsense Mutation in TAB2-encoded TGF-beta Activated Kinase 1 in a Child with Polyvalvular Syndrome.
  9. Our study provides insights into the mechanism of TAB3 regulating activity and suggests its important implications in triple negative breast cancer metastasis.
    Title: TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer.
  10. Data show that knockdown of transforming growth factor-activated kinase 1 (TAK1)-binding protein 3 (TAB3) inhibited proliferation of non-small cell lung cancer (NSCLC) cells.
    Title: TAB3 overexpression promotes cell proliferation in non-small cell lung cancer and mediates chemoresistance to CDDP in A549 cells via the NF-κB pathway.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr The ability of HIV-1 Vpr to activate NF-kappaB or activator protein 1-dependent luciferase expression requires TAK1, TRAF6, or TAB3 in cells PubMed
capsid gag The TAK1 kinase complex (TAK1/TAB2/TAB3) contributes to capsid-specific restriction mediated by TRIM5alpha. TRIM5alpha activates TAK1 autophosphorylation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC45404

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of autophagy TAS
Traceable Author Statement
more info
 PubMed 
involved_in non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
Names
NF-kappa-B-activating protein 1
NFkB activating protein 1
TAB-3
TAK1-binding protein 3
TGF-beta activated kinase 1 and MAP3K7 binding protein 3
TGF-beta-activated kinase 1-binding protein 3
mitogen-activated protein kinase kinase kinase 7 interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012845.2 RefSeqGene

    Range
    5141..66953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001399870.1 → NP_001386799.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC108359, AC117405, KF459043

  2. NM_001399872.1 → NP_001386801.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC108359, AC117405, KF459043
    Consensus CDS
    CCDS94584.1
    Related
    ENSP00000368214.2, ENST00000378932.6

  3. NM_001399873.1 → NP_001386802.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC108359, AC117405, KF459043

  4. NM_152787.5 → NP_690000.3  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_690000.3

    Status: REVIEWED

    Source sequence(s)
    AC108359, AC117405, AK096786, BC032526, DA494641
    Consensus CDS
    CCDS14226.1
    UniProtKB/Swiss-Prot
    A6NDD9, Q6VQR0, Q8N5C8
    UniProtKB/TrEMBL
    Q5JPK0
    Related
    ENSP00000288422.4, ENST00000288422.4
    Conserved Domains (4) summary
    smart00547
    Location:687 → 709
    ZnF_RBZ; Zinc finger domain
    PRK10263
    Location:245 → 345
    PRK10263; DNA translocase FtsK; Provisional
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    sd00029
    Location:687 → 706
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RNA

  1. NR_174361.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC108359, AC117405, KF459043

  2. NR_174362.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC108359, AC117405, KF459043

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    30827442..30889254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441986.1 → XP_047297942.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A6NDD9, Q6VQR0, Q8N5C8

  2. XM_017029400.2 → XP_016884889.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

    UniProtKB/TrEMBL
    Q5JPK0
    Conserved Domains (3) summary
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    pfam03153
    Location:122 → 291
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam13900
    Location:634 → 681
    GVQW; Putative domain of unknown function

  3. XM_047441987.1 → XP_047297943.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X3

  4. XM_011545488.3 → XP_011543790.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X4

    UniProtKB/TrEMBL
    F6SS63
    Conserved Domains (2) summary
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    pfam03153
    Location:122 → 291
    TFIIA; Transcription factor IIA, alpha/beta subunit

  5. XM_017029402.2 → XP_016884891.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X5

    UniProtKB/TrEMBL
    F6SS63
    Related
    ENSP00000433193.1, ENST00000467136.5

RNA

  1. XR_950433.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    30425653..30487452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326818.1 → XP_054182793.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A6NDD9, Q6VQR0, Q8N5C8

  2. XM_054326817.1 → XP_054182792.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

  3. XM_054326819.1 → XP_054182794.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X3

  4. XM_054326820.1 → XP_054182795.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X4

  5. XM_054326821.1 → XP_054182796.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X5

RNA

  1. XR_008485476.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198312.1: Suppressed sequence

    Description
    NM_198312.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N5C8.3 GenPept UniProtKB/Swiss-Prot:Q8N5C8

Gene LinkOut

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