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dlg1 discs large 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32083, updated on 22-Aug-2024

Summary

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Official Symbol
dlg1provided by FlyBase
Official Full Name
discs large 1provided by FlyBase
Primary source
FLYBASE:FBgn0001624
Locus tag
Dmel_CG1725
See related
AllianceGenome:FB:FBgn0001624
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
11; anon-EST:Posey93; anon-WO03040301.258; anon-WO03040301.260; anon-WO03040301.268; CG1725; CG1730; CPD; d. lg.-1; Discs Large; Discs-large; dlg; Dlg; DLG; dlg-1; dlg-A; Dlg-A; DLG-A; Dlg1; DLG1; dlgA; DlgA; dlgS97; DlgS97; Dmel\CG1725; Drodlg; l(1)10Bf; l(1)bwn; l(1)d.lg-1; l(1)d.lg.-1; l(1)discs large; l(1)dlg; l(1)dlg-1; l(1)dlg1; l(1)G0276; l(1)G0342; l(1)G0456; l(1)G19; l(1)l.pr.-2; l(1)L11; l(1)lpr-2; misb; PSD-95; PSD95; SAP97
Summary
Predicted to enable guanylate kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; basal protein localization; and oogenesis. Located in several cellular components, including apicolateral plasma membrane; tight junction; and type I terminal bouton. Colocalizes with presynaptic membrane. Is expressed in several structures, including epithelium; nervous system; reproductive system; retina; and somatic muscle cell. Used to study benign neoplasm; cancer; and carcinoma. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability; invasive ductal carcinoma; and non-syndromic X-linked intellectual disability 90. Orthologous to several human genes including DLG1 (discs large MAGUK scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See dlg1 in Genome Data Viewer
Location:
10B6-10B10; 1-34 cM
Exon count:
27
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11369665..11409776)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11263698..11303809)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene hopscotch Neighboring gene Tim8 Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 10b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The cell polarity determinant Dlg1 facilitates epithelial invagination by promoting tissue-scale mechanical coordination. Fuentes MA, et al. Development, 2022 Mar 15. PMID 35302584, Free PMC Article
  2. Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module. Ghosh A, et al. Biochemistry, 2018 Feb 27. PMID 29261291, Free PMC Article
  3. The precise subcellular localization of Dlg in the Drosophila larva body wall using improved pre-embedding immuno-EM. Gan G, et al. J Neurosci Res, 2018 Mar. PMID 29231975
  4. Enhanced sleep reverses memory deficits and underlying pathology in Drosophila models of Alzheimer's disease. Dissel S, et al. Neurobiol Sleep Circadian Rhythms, 2017 Jan. PMID 29094110, Free PMC Article
  5. Control of the developmental timer forDrosophila pupariation. Poodry CA, et al. Rouxs Arch Dev Biol, 1990 Apr. PMID 28306107

See all (1306) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Evidence for a nuclear role for Drosophila Dlg as a regulator of the NURF complex.
    Title: Evidence for a nuclear role for Drosophila Dlg as a regulator of the NURF complex.
  2. The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes.
    Title: The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes.
  3. Electrostatic plasma membrane targeting contributes to Dlg function in cell polarity and tumorigenesis.
    Title: Electrostatic plasma membrane targeting contributes to Dlg function in cell polarity and tumorigenesis.
  4. Molecular and cellular correlates in Kv channel clustering: entropy-based regulation of cluster ion channel density.
    Title: Molecular and cellular correlates in Kv channel clustering: entropy-based regulation of cluster ion channel density.
  5. the Scribble/Dlg module plays multiple roles in polarity initiation
    Title: Scribble and Discs-large direct initial assembly and positioning of adherens junctions during the establishment of apical-basal polarity.
  6. Scrib and Dlg are key components of the tricellular junction.
    Title: Scribble and Discs Large mediate tricellular junction formation.
  7. Data suggest that the discs large 1 protein (Dlg) and the clathrin-mediated endocytic (CME) machinery downregulate epidermal growth factor receptor (EGFR) signaling.
    Title: The Dlg Module and Clathrin-Mediated Endocytosis Regulate EGFR Signaling and Cyst Cell-Germline Coordination in the Drosophila Testis.
  8. findings reveal that Scrib's PDZ1 domain functions in the interaction with Gukh and that the Scrib-Gukh interaction has a key role in epithelial tissue development in Drosophila
    Title: Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.
  9. The authors find that the tumor suppressor Discs large (Dlg) links the Par complex component atypical Protein Kinase C (aPKC) to the essential spindle orientation factor GukHolder (GukH).
    Title: Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division.
  10. The structure of dlg1 reveals that the core of the dimer is formed by a distinctive six-helix assembly, involving all three conserved helices from each subunit (monomer). The homodimer interface is extended by the C-terminal tail of the L27 domain of Dlg1, which forms a two-stranded antiparallel beta-sheet. The structure reconciles and provides a structural context for a large body of available mutational data.
    Title: Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanylate kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior axis specification, follicular epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in asymmetric protein localization involved in cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in basal protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate commitment involved in pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure TAS
Traceable Author Statement
more info
 PubMed 
involved_in embryo development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of polarity of follicular epithelium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment or maintenance of polarity of larval imaginal disc epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gravitaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of a polarized epithelium TAS
Traceable Author Statement
more info
 PubMed 
involved_in morphogenesis of follicular epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of larval imaginal disc epithelium TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of negative regulation of peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pole plasm protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive phototaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor localization to synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in septate junction assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral plasma membrane HDA PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in leading edge membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in septate junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in smooth septate junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in subsynaptic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in tricellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in type I terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in type Ib terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
discs large 1
Names
CG1725-PA
CG1725-PB
CG1725-PC
CG1725-PD
CG1725-PE
CG1725-PF
CG1725-PG
CG1725-PH
CG1725-PI
CG1725-PJ
CG1725-PK
CG1725-PL
CG1725-PM
CG1725-PN
CG1725-PO
CG1725-PP
CG1725-PQ
CG1725-PR
CG1725-PS
CG1725-PT
CG1725-PU
Disc-Large
Discs-large
Discs-large 1
disc large
disclarge
discs large
discslarge
disk large
dlg1-PA
dlg1-PB
dlg1-PC
dlg1-PD
dlg1-PE
dlg1-PF
dlg1-PG
dlg1-PH
dlg1-PI
dlg1-PJ
dlg1-PK
dlg1-PL
dlg1-PM
dlg1-PN
dlg1-PO
dlg1-PP
dlg1-PQ
dlg1-PR
dlg1-PS
dlg1-PT
dlg1-PU
lethal(1)benign wing imaginal disc neoplasm
lethal(1)discs large
lethal(1)discs-large
lethal(2)discs large
NP_001096955.1
NP_001096956.1
NP_001162718.1
NP_001162719.1
NP_001162720.1
NP_001245622.1
NP_001245623.1
NP_001259446.1
NP_001259447.1
NP_001259448.1
NP_001259449.1
NP_511120.2
NP_727518.1
NP_727519.1
NP_727520.1
NP_996402.1
NP_996403.1
NP_996404.1
NP_996405.1
NP_996406.1
NP_996407.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11369665..11409776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103486.3 → NP_001096956.1  discs large 1, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096956.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31007
    Conserved Domains (6) summary
    cd11861
    Location:573 → 633
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:763 → 933
    GuKc; Guanylate kinase homologues
    smart00228
    Location:165 → 251
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:453 → 531
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:755 → 933
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:4 → 62
    L27_1; L27_1

  2. NM_206683.4 → NP_996406.1  discs large 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996406.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4A8, A4V4B0, A8JUR9, A8JUS0, C7LAH6, P31007, Q7KV38, Q7KV39, Q7KV40, Q7YXH8, Q8SY37, Q8T0C6, Q95TF5, Q9VYZ4, Q9VYZ5, Q9VYZ6
    Conserved Domains (6) summary
    cd11861
    Location:624 → 684
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:787 → 957
    GuKc; Guanylate kinase homologues
    smart00228
    Location:216 → 302
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:504 → 582
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:779 → 957
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:4 → 62
    L27_1; L27_1

  3. NM_206681.4 → NP_996404.1  discs large 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996404.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31007
    Conserved Domains (6) summary
    cd11861
    Location:565 → 625
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:728 → 898
    GuKc; Guanylate kinase homologues
    smart00228
    Location:157 → 243
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:445 → 523
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:720 → 898
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:4 → 62
    L27_1; L27_1

  4. NM_167280.2 → NP_727518.1  discs large 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727518.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31007
    Related
    FBpp0073339
    Conserved Domains (1) summary
    pfam09058
    Location:4 → 62
    L27_1; L27_1

  5. NM_001272520.1 → NP_001259449.1  discs large 1, isoform U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259449.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEB3
    Conserved Domains (1) summary
    pfam09058
    Location:4 → 62
    L27_1; L27_1

  6. NM_206680.2 → NP_996403.1  discs large 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996403.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31007
    Conserved Domains (1) summary
    pfam09058
    Location:4 → 62
    L27_1; L27_1

  7. NM_206679.2 → NP_996402.1  discs large 1, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996402.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31007
    Conserved Domains (1) summary
    pfam09058
    Location:4 → 62
    L27_1; L27_1

  8. NM_001169249.3 → NP_001162720.1  discs large 1, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162720.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C536
    Conserved Domains (1) summary
    pfam09058
    Location:4 → 62
    L27_1; L27_1

  9. NM_167281.2 → NP_727519.1  discs large 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727519.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31007
    Related
    FBpp0073340
    Conserved Domains (3) summary
    smart00228
    Location:513 → 599
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:625 → 714
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09058
    Location:303 → 359
    L27_1; L27_1

  10. NM_001169247.1 → NP_001162718.1  discs large 1, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162718.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJH5
    Conserved Domains (4) summary
    cd11861
    Location:862 → 922
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00228
    Location:454 → 540
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:742 → 820
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09058
    Location:303 → 359
    L27_1; L27_1

  11. NM_001103485.3 → NP_001096955.1  discs large 1, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096955.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31007
    Conserved Domains (5) summary
    cd11861
    Location:565 → 625
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:728 → 898
    GuKc; Guanylate kinase homologues
    smart00228
    Location:157 → 243
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:445 → 523
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:720 → 898
    Guanylate_kin; Guanylate kinase

  12. NM_001272518.1 → NP_001259447.1  discs large 1, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259447.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJH6
    Conserved Domains (5) summary
    cd11861
    Location:604 → 664
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:777 → 947
    GuKc; Guanylate kinase homologues
    smart00228
    Location:40 → 126
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:484 → 562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:769 → 947
    Guanylate_kin; Guanylate kinase

  13. NM_001258694.2 → NP_001245623.1  discs large 1, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245623.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NGZ2
    Conserved Domains (5) summary
    cd11861
    Location:604 → 664
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:792 → 962
    GuKc; Guanylate kinase homologues
    smart00228
    Location:40 → 126
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:484 → 562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:784 → 962
    Guanylate_kin; Guanylate kinase

  14. NM_206682.4 → NP_996405.1  discs large 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996405.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NGZ2
    Conserved Domains (5) summary
    cd11861
    Location:604 → 664
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:792 → 962
    GuKc; Guanylate kinase homologues
    smart00228
    Location:40 → 126
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:484 → 562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:784 → 962
    Guanylate_kin; Guanylate kinase

  15. NM_078565.5 → NP_511120.2  discs large 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511120.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJH6
    Related
    FBpp0073341
    Conserved Domains (5) summary
    cd11861
    Location:604 → 664
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:777 → 947
    GuKc; Guanylate kinase homologues
    smart00228
    Location:40 → 126
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:484 → 562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:769 → 947
    Guanylate_kin; Guanylate kinase

  16. NM_001272517.1 → NP_001259446.1  discs large 1, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259446.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHK8
    Conserved Domains (5) summary
    cd11861
    Location:604 → 664
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:777 → 947
    GuKc; Guanylate kinase homologues
    smart00228
    Location:40 → 126
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:484 → 562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:769 → 947
    Guanylate_kin; Guanylate kinase

  17. NM_206684.4 → NP_996407.1  discs large 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996407.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJH6
    Conserved Domains (5) summary
    cd11861
    Location:604 → 664
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:777 → 947
    GuKc; Guanylate kinase homologues
    smart00228
    Location:40 → 126
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:484 → 562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:769 → 947
    Guanylate_kin; Guanylate kinase

  18. NM_001272519.1 → NP_001259448.1  discs large 1, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259448.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PJI4
    Conserved Domains (5) summary
    cd11861
    Location:612 → 672
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:760 → 930
    GuKc; Guanylate kinase homologues
    smart00228
    Location:48 → 134
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:492 → 570
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:752 → 930
    Guanylate_kin; Guanylate kinase

  19. NM_167282.4 → NP_727520.1  discs large 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727520.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31007
    Related
    FBpp0073342
    Conserved Domains (5) summary
    cd11861
    Location:612 → 672
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:785 → 955
    GuKc; Guanylate kinase homologues
    smart00228
    Location:48 → 134
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:492 → 570
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:777 → 955
    Guanylate_kin; Guanylate kinase

  20. NM_001169248.2 → NP_001162719.1  discs large 1, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162719.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJH6
    Conserved Domains (5) summary
    cd11861
    Location:604 → 664
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:777 → 947
    GuKc; Guanylate kinase homologues
    smart00228
    Location:40 → 126
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:484 → 562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:769 → 947
    Guanylate_kin; Guanylate kinase

  21. NM_001258693.1 → NP_001245622.1  discs large 1, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245622.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH13
    Conserved Domains (5) summary
    cd11861
    Location:612 → 672
    SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins
    smart00072
    Location:800 → 970
    GuKc; Guanylate kinase homologues
    smart00228
    Location:48 → 134
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:492 → 570
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:792 → 970
    Guanylate_kin; Guanylate kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C1C536 C1C536
E1JJH5 E1JJH5
E1JJH6 E1JJH6
E8NH13 E8NH13
M9NGZ2 M9NGZ2
M9PEB3 M9PEB3
M9PHK8 M9PHK8
M9PJI4 M9PJI4
P31007.2 P31007
Q4PLW2 Q4PLW2

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