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APC APC regulator of WNT signaling pathway [ Homo sapiens (human) ]

Gene ID: 324, updated on 18-Nov-2024

Summary

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Official Symbol
APCprovided by HGNC
Official Full Name
APC regulator of WNT signaling pathwayprovided by HGNC
Primary source
HGNC:HGNC:583
See related
Ensembl:ENSG00000134982 MIM:611731; AllianceGenome:HGNC:583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46
Summary
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022]
Annotation information
Note: PROC (Gene ID: 5624) and APC (Gene ID: 324) loci share the APC symbol/alias in common. [08 Feb 2019]
Expression
Ubiquitous expression in brain (RPKM 25.7), colon (RPKM 4.5) and 23 other tissues See more
Orthologs
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Genomic context

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See APC in Genome Data Viewer
Location:
5q22.2
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (112707498..112846239)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (113218062..113356772)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112043195..112181936)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2200 Neighboring gene uncharacterized LOC102467216 Neighboring gene Sharpr-MPRA regulatory region 7502 Neighboring gene Sharpr-MPRA regulatory region 14787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22910 Neighboring gene RNA, U6 small nuclear 482, pseudogene Neighboring gene CBX3 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 9882 Neighboring gene signal recognition particle 19 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:112226954-112228153 Neighboring gene receptor accessory protein 5 Neighboring gene X-box binding protein 1 pseudogene 1 Neighboring gene ZRSR2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Analysis of rare APC variants at the mRNA level: six pathogenic mutations and literature review. Kaufmann A, et al. J Mol Diagn, 2009 Mar. PMID 19196998, Free PMC Article
  2. Novel human pathological mutations. Gene symbol: APC. Disease: Adenomatous polyposis coli. Mavrogiannis LA, et al. Hum Genet, 2009 Aug. PMID 19694001
  3. APC somatic mosaicism in a patient with Gardner syndrome carrying the E1573X mutation: report of a case. Filipe B, et al. Dis Colon Rectum, 2009 Aug. PMID 19617769
  4. [Polymorphism/loss of heterozygosity of APC gene in GERD-Barrett's metaplasia-dysplasia-adenocarcinoma sequence]. Mokrowiecka A, et al. Pol Merkur Lekarski, 2009 May. PMID 19606680
  5. Genotype predicting phenotype in familial adenomatous polyposis: a practical application to the choice of surgery. Nieuwenhuis MH, et al. Dis Colon Rectum, 2009 Jul. PMID 19571702

See all (1000) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. APC and ZBTB2 May Mediate M2 Macrophage Infiltration to Promote the Development of Renal Fibrosis: A Bioinformatics Analysis.
    Title: APC and ZBTB2 May Mediate M2 Macrophage Infiltration to Promote the Development of Renal Fibrosis: A Bioinformatics Analysis.
  2. Plasma-Derived Extracellular Vesicles and Non-Extracellular Vesicle Components from APC[Min/+] Mice Promote Pro-Tumorigenic Activities and Activate Human Colonic Fibroblasts via the NF-kappaB Signaling Pathway.
    Title: Plasma-Derived Extracellular Vesicles and Non-Extracellular Vesicle Components from APC(Min/+) Mice Promote Pro-Tumorigenic Activities and Activate Human Colonic Fibroblasts via the NF-κB Signaling Pathway.
  3. Bcl-2 Up-Regulation Mediates Taxane Resistance Downstream of APC Loss.
    Title: Bcl-2 Up-Regulation Mediates Taxane Resistance Downstream of APC Loss.
  4. Mutational analysis of pulmonary large cell neuroendocrine carcinoma: APC gene mutations identify a good prognostic factor.
    Title: Mutational analysis of pulmonary large cell neuroendocrine carcinoma: APC gene mutations identify a good prognostic factor.
  5. BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.
    Title: BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.
  6. beta-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53.
    Title: β-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53.
  7. Case Series of Men with the Germline APC I1307K variant and Treatment-Emergent Neuroendocrine Prostate Cancer.
    Title: Case Series of Men with the Germline APC I1307K variant and Treatment-Emergent Neuroendocrine Prostate Cancer.
  8. Clinical features and distribution of the APC variant in duodenal and ampullary polyps in patients with familial adenomatous polyposis: a multicenter retrospective cohort study in Japan.
    Title: Clinical features and distribution of the APC variant in duodenal and ampullary polyps in patients with familial adenomatous polyposis: a multicenter retrospective cohort study in Japan.
  9. A novel APC mutation associated with Gardner syndrome in a Chinese family.
    Title: A novel APC mutation associated with Gardner syndrome in a Chinese family.
  10. APC mutations disrupt beta-catenin destruction complex condensates organized by Axin phase separation.
    Title: APC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation.
Submit: New GeneRIF Correction See all GeneRIFs (691)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in APC that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Associated conditions

Description Tests
Colorectal cancer
MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome
Compare labs
Desmoid disease, hereditary
MedGen: C1851124 OMIM: 135290 GeneReviews: APC-Associated Polyposis Conditions
Compare labs
Familial adenomatous polyposis 1
MedGen: C2713442 OMIM: 175100 GeneReviews: APC-Associated Polyposis Conditions
Compare labs
Familial multiple polyposis syndrome
MedGen: C0032580 GeneReviews: Not available
Compare labs
Gastric adenocarcinoma and proximal polyposis of the stomach
MedGen: C4749917 OMIM: 619182 GeneReviews: APC-Associated Polyposis Conditions
Compare labs
Gastric cancer
MedGen: C0024623 OMIM: 613659 GeneReviews: Not available
Compare labs
Hepatocellular carcinoma
MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-07-18)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2021-07-18)

ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: SRP19

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding EXP
Inferred from Experiment
more info
 PubMed 
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables cadherin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables dynein complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables gamma-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-catenin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in bicellular tight junction assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocardial cushion morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heart valve development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell cycle G1/S phase transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of microtubule depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of protein catabolic process IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of pseudopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of attachment of spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of microtubule-based movement IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
part_of Wnt signalosome NAS
Non-traceable Author Statement
more info
 PubMed 
colocalizes_with adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
part_of beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of beta-catenin destruction complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenomatous polyposis coli protein
Names
APC, WNT signaling pathway regulator
WNT signaling pathway regulator
adenomatosis polyposis coli tumor suppressor
adenomatous polyposis coli (APC)
deleted in polyposis 2.5
epididymis secretory sperm binding protein
protein phosphatase 1, regulatory subunit 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008481.4 RefSeqGene

    Range
    19985..158719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_130

mRNA and Protein(s)

  1. NM_000038.6 → NP_000029.2  adenomatous polyposis coli protein isoform b

    See identical proteins and their annotated locations for NP_000029.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AB210001, CA313732, DA795663, M73548
    Consensus CDS
    CCDS4107.1
    UniProtKB/Swiss-Prot
    B7Z2B6, D3DT03, P25054, Q15162, Q15163, Q93042
    UniProtKB/TrEMBL
    A0A224ANK2
    Related
    ENSP00000257430.4, ENST00000257430.9
    Conserved Domains (17) summary
    smart00185
    Location:649 → 689
    ARM; Armadillo/beta-catenin-like repeats
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:465 → 508
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1637 → 1660
    APC_r; APC repeat
    pfam05924
    Location:2033 → 2052
    SAMP; SAMP Motif
    pfam05937
    Location:2670 → 2843
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2223 → 2568
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:732 → 1018
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1036 → 1135
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1283 → 1368
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1662 → 1715
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1746 → 1839
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1873 → 1947
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl21727
    Location:533 → 734
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    cl25732
    Location:4 → 272
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:1291 → 1701
    DUF4045; Domain of unknown function (DUF4045)

  2. NM_001127510.3 → NP_001120982.1  adenomatous polyposis coli protein isoform b

    See identical proteins and their annotated locations for NP_001120982.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AB210001, CA313732, DA795663
    Consensus CDS
    CCDS4107.1
    UniProtKB/Swiss-Prot
    B7Z2B6, D3DT03, P25054, Q15162, Q15163, Q93042
    UniProtKB/TrEMBL
    A0A224ANK2
    Related
    ENSP00000427089.2, ENST00000508376.6
    Conserved Domains (17) summary
    smart00185
    Location:649 → 689
    ARM; Armadillo/beta-catenin-like repeats
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:465 → 508
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1637 → 1660
    APC_r; APC repeat
    pfam05924
    Location:2033 → 2052
    SAMP; SAMP Motif
    pfam05937
    Location:2670 → 2843
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2223 → 2568
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:732 → 1018
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1036 → 1135
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1283 → 1368
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1662 → 1715
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1746 → 1839
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1873 → 1947
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl21727
    Location:533 → 734
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    cl25732
    Location:4 → 272
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:1291 → 1701
    DUF4045; Domain of unknown function (DUF4045)

  3. NM_001127511.3 → NP_001120983.2  adenomatous polyposis coli protein isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (a).
    Source sequence(s)
    AB210001, AC136500, AK294544, BP230350, CA313732
    UniProtKB/TrEMBL
    A0A224AV41
    Related
    ENSP00000423224.2, ENST00000507379.6
    Conserved Domains (13) summary
    cd00020
    Location:593 → 713
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:1619 → 1643
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:2016 → 2035
    SAMP; SAMP Motif
    pfam05937
    Location:2652 → 2825
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2205 → 2550
    APC_basic; APC basic domain
    pfam11414
    Location:137 → 217
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:714 → 1001
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1018 → 1117
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1265 → 1350
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1644 → 1700
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1721 → 1821
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1858 → 1929
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:447 → 490
    ARM; armadillo repeat [structural motif]

  4. NM_001354895.2 → NP_001341824.1  adenomatous polyposis coli protein isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
    Source sequence(s)
    AC008575, AC136500
    Consensus CDS
    CCDS4107.1
    UniProtKB/Swiss-Prot
    B7Z2B6, D3DT03, P25054, Q15162, Q15163, Q93042
    UniProtKB/TrEMBL
    A0A224ANK2
    Conserved Domains (17) summary
    smart00185
    Location:649 → 689
    ARM; Armadillo/beta-catenin-like repeats
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:465 → 508
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1637 → 1660
    APC_r; APC repeat
    pfam05924
    Location:2033 → 2052
    SAMP; SAMP Motif
    pfam05937
    Location:2670 → 2843
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2223 → 2568
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:732 → 1018
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1036 → 1135
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1283 → 1368
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1662 → 1715
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1746 → 1839
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1873 → 1947
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl21727
    Location:533 → 734
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    cl25732
    Location:4 → 272
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:1291 → 1701
    DUF4045; Domain of unknown function (DUF4045)

  5. NM_001354896.2 → NP_001341825.1  adenomatous polyposis coli protein isoform c

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    A0A224ANK2, R4GMU6
    Related
    ENSP00000473355.2, ENST00000504915.3
    Conserved Domains (17) summary
    smart00185
    Location:667 → 707
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:709 → 749
    Arm; Armadillo/beta-catenin-like repeat
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:581 → 613
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1655 → 1678
    APC_r; APC repeat
    pfam05924
    Location:2051 → 2070
    SAMP; SAMP Motif
    pfam05937
    Location:2688 → 2861
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2241 → 2586
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:750 → 1036
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1054 → 1153
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1301 → 1386
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1680 → 1733
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1764 → 1857
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1891 → 1965
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25732
    Location:4 → 272
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:1309 → 1719
    DUF4045; Domain of unknown function (DUF4045)

  6. NM_001354897.2 → NP_001341826.1  adenomatous polyposis coli protein isoform d

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    A0A224AV41
    Conserved Domains (15) summary
    smart00185
    Location:659 → 699
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:701 → 741
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:475 → 518
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1647 → 1670
    APC_r; APC repeat
    pfam05924
    Location:2043 → 2062
    SAMP; SAMP Motif
    pfam05937
    Location:2680 → 2853
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2233 → 2578
    APC_basic; APC basic domain
    pfam11414
    Location:137 → 217
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:742 → 1028
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1046 → 1145
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1293 → 1378
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1672 → 1725
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1756 → 1849
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1883 → 1957
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:1301 → 1711
    DUF4045; Domain of unknown function (DUF4045)

  7. NM_001354898.2 → NP_001341827.1  adenomatous polyposis coli protein isoform e

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    A0A224ANK2
    Conserved Domains (15) summary
    smart00185
    Location:624 → 664
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:666 → 706
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:440 → 483
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1612 → 1635
    APC_r; APC repeat
    pfam05924
    Location:2008 → 2027
    SAMP; SAMP Motif
    pfam05937
    Location:2645 → 2818
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2198 → 2543
    APC_basic; APC basic domain
    pfam11414
    Location:102 → 182
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:707 → 993
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1011 → 1110
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1258 → 1343
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1637 → 1690
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1721 → 1814
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1848 → 1922
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:1266 → 1676
    DUF4045; Domain of unknown function (DUF4045)

  8. NM_001354899.2 → NP_001341828.1  adenomatous polyposis coli protein isoform f

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    A0A224ANK2
    Conserved Domains (16) summary
    smart00185
    Location:621 → 661
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:663 → 703
    Arm; Armadillo/beta-catenin-like repeat
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:437 → 480
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1609 → 1632
    APC_r; APC repeat
    pfam05924
    Location:2005 → 2024
    SAMP; SAMP Motif
    pfam05937
    Location:2642 → 2815
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2195 → 2540
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:704 → 990
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1008 → 1107
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1255 → 1340
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1634 → 1687
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1718 → 1811
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1845 → 1919
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:1263 → 1673
    DUF4045; Domain of unknown function (DUF4045)

  9. NM_001354900.2 → NP_001341829.1  adenomatous polyposis coli protein isoform g

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    A0AAQ5BGJ9
    Conserved Domains (15) summary
    smart00185
    Location:608 → 648
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:650 → 690
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:522 → 554
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1596 → 1619
    APC_r; APC repeat
    pfam05924
    Location:1992 → 2011
    SAMP; SAMP Motif
    pfam05937
    Location:2629 → 2802
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2182 → 2527
    APC_basic; APC basic domain
    pfam11414
    Location:68 → 148
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:691 → 977
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:995 → 1094
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1242 → 1327
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1621 → 1674
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1705 → 1798
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1832 → 1906
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:1250 → 1660
    DUF4045; Domain of unknown function (DUF4045)

  10. NM_001354901.2 → NP_001341830.1  adenomatous polyposis coli protein isoform h

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    A0AAQ5BGJ9
    Related
    ENSP00000518940.1, ENST00000713639.1
    Conserved Domains (15) summary
    smart00185
    Location:590 → 630
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:632 → 672
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:406 → 449
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1578 → 1601
    APC_r; APC repeat
    pfam05924
    Location:1974 → 1993
    SAMP; SAMP Motif
    pfam05937
    Location:2611 → 2784
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2164 → 2509
    APC_basic; APC basic domain
    pfam11414
    Location:68 → 148
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:673 → 959
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:977 → 1076
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1224 → 1309
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1603 → 1656
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1687 → 1780
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1814 → 1888
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:1232 → 1642
    DUF4045; Domain of unknown function (DUF4045)

  11. NM_001354902.2 → NP_001341831.1  adenomatous polyposis coli protein isoform i

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    A0A224AV41
    Conserved Domains (15) summary
    smart00185
    Location:558 → 598
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:600 → 640
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:374 → 417
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1546 → 1569
    APC_r; APC repeat
    pfam05924
    Location:1942 → 1961
    SAMP; SAMP Motif
    pfam05937
    Location:2579 → 2752
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2132 → 2477
    APC_basic; APC basic domain
    pfam11414
    Location:137 → 217
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:641 → 927
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:945 → 1044
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1192 → 1277
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1571 → 1624
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1655 → 1748
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1782 → 1856
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:1200 → 1610
    DUF4045; Domain of unknown function (DUF4045)

  12. NM_001354903.2 → NP_001341832.1  adenomatous polyposis coli protein isoform j

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    A0A224ANK2
    Conserved Domains (17) summary
    smart00185
    Location:548 → 588
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:590 → 630
    Arm; Armadillo/beta-catenin-like repeat
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:364 → 407
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1536 → 1559
    APC_r; APC repeat
    pfam05924
    Location:1932 → 1951
    SAMP; SAMP Motif
    pfam05937
    Location:2569 → 2742
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2122 → 2467
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:631 → 917
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:935 → 1034
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1182 → 1267
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1561 → 1614
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1645 → 1738
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1772 → 1846
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25732
    Location:4 → 272
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:1190 → 1600
    DUF4045; Domain of unknown function (DUF4045)

  13. NM_001354904.2 → NP_001341833.1  adenomatous polyposis coli protein isoform k

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    A0AAQ5BGJ9
    Conserved Domains (15) summary
    smart00185
    Location:523 → 563
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:565 → 605
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:339 → 382
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1511 → 1534
    APC_r; APC repeat
    pfam05924
    Location:1907 → 1926
    SAMP; SAMP Motif
    pfam05937
    Location:2544 → 2717
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2097 → 2442
    APC_basic; APC basic domain
    pfam11414
    Location:102 → 182
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:606 → 892
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:910 → 1009
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1157 → 1242
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1536 → 1589
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1620 → 1713
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1747 → 1821
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:1165 → 1575
    DUF4045; Domain of unknown function (DUF4045)

  14. NM_001354905.2 → NP_001341834.1  adenomatous polyposis coli protein isoform l

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    A0AAQ5BGJ9
    Conserved Domains (15) summary
    smart00185
    Location:489 → 529
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:531 → 571
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:305 → 348
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1477 → 1500
    APC_r; APC repeat
    pfam05924
    Location:1873 → 1892
    SAMP; SAMP Motif
    pfam05937
    Location:2510 → 2683
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2063 → 2408
    APC_basic; APC basic domain
    pfam11414
    Location:68 → 148
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:572 → 858
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:876 → 975
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1123 → 1208
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1502 → 1555
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1586 → 1679
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1713 → 1787
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:1131 → 1541
    DUF4045; Domain of unknown function (DUF4045)

  15. NM_001354906.2 → NP_001341835.1  adenomatous polyposis coli protein isoform m

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    A0AAQ5BGJ9
    Conserved Domains (14) summary
    smart00185
    Location:366 → 406
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:408 → 448
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:182 → 225
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1354 → 1377
    APC_r; APC repeat
    pfam05924
    Location:1750 → 1769
    SAMP; SAMP Motif
    pfam05937
    Location:2387 → 2560
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:1940 → 2285
    APC_basic; APC basic domain
    pfam16629
    Location:449 → 735
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:753 → 852
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1000 → 1085
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1379 → 1432
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1463 → 1556
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1590 → 1664
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:1008 → 1418
    DUF4045; Domain of unknown function (DUF4045)

  16. NM_001407446.1 → NP_001394375.1  adenomatous polyposis coli protein isoform n

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  17. NM_001407447.1 → NP_001394376.1  adenomatous polyposis coli protein isoform c

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    R4GMU6

  18. NM_001407448.1 → NP_001394377.1  adenomatous polyposis coli protein isoform c

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    R4GMU6

  19. NM_001407449.1 → NP_001394378.1  adenomatous polyposis coli protein isoform c

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/TrEMBL
    R4GMU6

  20. NM_001407450.1 → NP_001394379.1  adenomatous polyposis coli protein isoform b

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    UniProtKB/Swiss-Prot
    B7Z2B6, D3DT03, P25054, Q15162, Q15163, Q93042
    Related
    ENSP00000426541.2, ENST00000509732.6

  21. NM_001407451.1 → NP_001394380.1  adenomatous polyposis coli protein isoform o

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  22. NM_001407452.1 → NP_001394381.1  adenomatous polyposis coli protein isoform p

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  23. NM_001407453.1 → NP_001394382.1  adenomatous polyposis coli protein isoform h

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  24. NM_001407454.1 → NP_001394383.1  adenomatous polyposis coli protein isoform q

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  25. NM_001407455.1 → NP_001394384.1  adenomatous polyposis coli protein isoform q

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  26. NM_001407456.1 → NP_001394385.1  adenomatous polyposis coli protein isoform q

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  27. NM_001407457.1 → NP_001394386.1  adenomatous polyposis coli protein isoform q

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  28. NM_001407458.1 → NP_001394387.1  adenomatous polyposis coli protein isoform j

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  29. NM_001407459.1 → NP_001394388.1  adenomatous polyposis coli protein isoform j

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  30. NM_001407460.1 → NP_001394389.1  adenomatous polyposis coli protein isoform j

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  31. NM_001407467.1 → NP_001394396.1  adenomatous polyposis coli protein isoform r

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  32. NM_001407469.1 → NP_001394398.1  adenomatous polyposis coli protein isoform r

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  33. NM_001407470.1 → NP_001394399.1  adenomatous polyposis coli protein isoform m

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  34. NM_001407471.1 → NP_001394400.1  adenomatous polyposis coli protein isoform s

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

  35. NM_001407472.1 → NP_001394401.1  adenomatous polyposis coli protein isoform s

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

RNA

  1. NR_176365.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    Related
    ENST00000505350.2

  2. NR_176366.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    112707498..112846239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    113218062..113356772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25054.2 GenPept UniProtKB/Swiss-Prot:P25054

Gene LinkOut

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