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ab abrupt [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34560, updated on 4-Jul-2024

Summary

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Official Symbol
abprovided by FlyBase
Official Full Name
abruptprovided by FlyBase
Primary source
FLYBASE:FBgn0264442
Locus tag
Dmel_CG43860
See related
AllianceGenome:FB:FBgn0264442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Ab; B2149; CG32830; CG43860; CG4807; clu; Dmel\CG43860; l(2)k02807; ptd
Old locus tag
Dmel_CG32830; Dmel_CG4807
Summary
Involved in several processes, including border follicle cell migration; muscle attachment; and nervous system development. Located in nucleus. Is expressed in several structures, including Kenyon cell; anterior-posterior subdivision of organism; cuboidal/columnar epithelium; extended germ band embryo; and stomatogastric nervous system. Orthologous to human ZBTB12 (zinc finger and BTB domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
32E1-32E2; 2-44 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11210678..11261080)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11210678..11261080)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ca2+-channel-protein-beta-subunit Neighboring gene Buddy of Hmr 2 Neighboring gene long non-coding RNA:CR43859 Neighboring gene CENP-meta Neighboring gene CENP-ana Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The BTB-zinc finger transcription factor abrupt acts as an epithelial oncogene in Drosophila melanogaster through maintaining a progenitor-like cell state. Turkel N, et al. PLoS Genet, 2013. PMID 23874226, Free PMC Article
  2. BTB/POZ-zinc finger protein abrupt suppresses dendritic branching in a neuronal subtype-specific and dosage-dependent manner. Li W, et al. Neuron, 2004 Sep 16. PMID 15363393
  3. Comparative developmental analysis of Drosophila and Tribolium reveals conserved and diverged roles of abrupt in insect wing evolution. Ravisankar P, et al. Dev Biol, 2016 Jan 15. PMID 26687509
  4. Development of morphological diversity of dendrites in Drosophila by the BTB-zinc finger protein abrupt. Sugimura K, et al. Neuron, 2004 Sep 16. PMID 15363392
  5. Evolved Repression Overcomes Enhancer Robustness. Preger-Ben Noon E, et al. Dev Cell, 2016 Dec 5. PMID 27840106

See all (149) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings define a miR-306-abrupt regulatory axis that controls wing and haltere size
    Title: The microRNA-306/abrupt regulatory axis controls wing and haltere growth in Drosophila.
  2. ab is essential for proper wing vein patterning both in Tribolium and Drosophila.
    Title: Comparative developmental analysis of Drosophila and Tribolium reveals conserved and diverged roles of abrupt in insect wing evolution.
  3. The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively.
    Title: Sensory-neuron subtype-specific transcriptional programs controlling dendrite morphogenesis: genome-wide analysis of Abrupt and Knot/Collier.
  4. Abrupt is a repressor of ecdysone signalling and border-cell migration in ovarian follicles. Abrupt represents a node of integration for steroid hormone and JAK-STAT signals.
    Title: Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt.
  5. The dendritic branching can be suppressed by neuronal subtype-specific transcription factors in a cell-autonomous and dosage-dependent manner.
    Title: BTB/POZ-zinc finger protein abrupt suppresses dendritic branching in a neuronal subtype-specific and dosage-dependent manner.
  6. Ab endows characteristics of dendritic morphogenesis of the class I ofdendritic arborization (da)neurons.
    Title: Development of morphological diversity of dendrites in Drosophila by the BTB-zinc finger protein abrupt.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon choice point recognition TAS
Traceable Author Statement
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic target recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
abrupt
Names
CG43860-PA
CG43860-PB
CG43860-PD
CG43860-PE
CG43860-PF
ab-PA
ab-PB
ab-PD
ab-PE
ab-PF
clueless
parted

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11210678..11261080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057214.5 → NP_476562.1  abrupt, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476562.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JHF4, Q24174, Q86NP4, Q9VKI1
    Related
    FBpp0304816
    Conserved Domains (4) summary
    smart00225
    Location:104 → 189
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00020
    Location:546 → 567
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:93 → 189
    BTB; BTB/POZ domain
    pfam05605
    Location:545 → 597
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  2. NM_057215.5 → NP_476563.1  abrupt, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476563.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24174
    Related
    FBpp0304818
    Conserved Domains (4) summary
    smart00225
    Location:104 → 189
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00020
    Location:536 → 557
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:93 → 189
    BTB; BTB/POZ domain
    pfam05605
    Location:535 → 587
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  3. NM_001169481.2 → NP_001162952.1  abrupt, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162952.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24174
    Conserved Domains (4) summary
    smart00225
    Location:104 → 189
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00020
    Location:536 → 557
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:93 → 189
    BTB; BTB/POZ domain
    pfam05605
    Location:535 → 587
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  4. NM_001273449.1 → NP_001260378.1  abrupt, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260378.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PB99
    Conserved Domains (3) summary
    smart00225
    Location:104 → 189
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:825 → 845
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:93 → 189
    BTB; BTB/POZ domain

  5. NM_001273450.1 → NP_001260379.1  abrupt, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260379.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24174
    Conserved Domains (4) summary
    smart00225
    Location:104 → 189
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00020
    Location:536 → 557
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:93 → 189
    BTB; BTB/POZ domain
    pfam05605
    Location:535 → 587
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PB99 M9PB99
Q24174.2 Q24174

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