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SPRED3 sprouty related EVH1 domain containing 3 [ Homo sapiens (human) ]

Gene ID: 399473, updated on 14-Nov-2024

Summary

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Official Symbol
SPRED3provided by HGNC
Official Full Name
sprouty related EVH1 domain containing 3provided by HGNC
Primary source
HGNC:HGNC:31041
See related
Ensembl:ENSG00000188766 MIM:609293; AllianceGenome:HGNC:31041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Eve-3; spred-3
Summary
This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Broad expression in brain (RPKM 1.8), duodenum (RPKM 0.4) and 14 other tissues See more
Orthologs
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Genomic context

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See SPRED3 in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38388697..38399587)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41190872..41201764)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38879337..38890227)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38865120-38865750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10571 Neighboring gene Sharpr-MPRA regulatory region 13764 Neighboring gene proteasome 26S subunit, non-ATPase 8 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:38890799-38890957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10573 Neighboring gene gametogenetin Neighboring gene family with sequence similarity 98 member C Neighboring gene RAS guanyl releasing protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38917687-38918201 Neighboring gene MPRA-validated peak3471 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10575 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38925085-38925660 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:38932363-38932538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38932982-38933942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38943427-38943954 Neighboring gene MPRA-validated peak3472 silencer Neighboring gene ryanodine receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38953733-38954234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38954745-38955341 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:38969337-38969680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38986475-38987366 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:38995830-38997029 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14573 Neighboring gene uncharacterized LOC124904710

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SPRED3 regulates the NF-κB signaling pathway in thyroid cancer and promotes the proliferation. Chen Z, et al. Sci Rep, 2024 Sep 3. PMID 39227612, Free PMC Article
  2. Bioinformatics analysis for the identification of Sprouty-related EVH1 domain-containing protein 3 expression and its clinical significance in thyroid carcinoma. Zhang X, et al. Sci Rep, 2024 Feb 24. PMID 38402263, Free PMC Article
  3. Eve-3: a liver enriched suppressor of Ras/MAPK signaling. King JA, et al. J Hepatol, 2006 Apr. PMID 16478641
  4. Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma. Mizoguchi M, et al. Neurogenetics, 2004 Feb. PMID 14618415
  5. Sprouty proteins: modified modulators, matchmakers or missing links? Guy GR, et al. J Endocrinol, 2009 Nov. PMID 19423641

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SPRED3 regulates the NF-kappaB signaling pathway in thyroid cancer and promotes the proliferation.
    Title: SPRED3 regulates the NF-κB signaling pathway in thyroid cancer and promotes the proliferation.
  2. Bioinformatics analysis for the identification of Sprouty-related EVH1 domain-containing protein 3 expression and its clinical significance in thyroid carcinoma.
    Title: Bioinformatics analysis for the identification of Sprouty-related EVH1 domain-containing protein 3 expression and its clinical significance in thyroid carcinoma.
  3. Eve-3 may act as an inhibitor of proliferation pathways in the mature liver and be involved in modulating the unique regenerative capacity of this organ
    Title: Eve-3: a liver enriched suppressor of Ras/MAPK signaling.
  4. The finding of Spred-3 revealed the presence of a novel family of regulators for the Ras/MAP kinase pathway, each member of which may have different specificities for extracellular signals. [Spred-3]
    Title: Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • AC005789.11

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of lens fiber cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sprouty-related, EVH1 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042522.3 → NP_001035987.1  sprouty-related, EVH1 domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001035987.1

    Status: REVIEWED

    Source sequence(s)
    AC005789
    Consensus CDS
    CCDS42560.1
    UniProtKB/Swiss-Prot
    Q2MJR0, Q2MJR1
    UniProtKB/TrEMBL
    B9EKV1
    Related
    ENSP00000345405.4, ENST00000338502.8
    Conserved Domains (2) summary
    cd10574
    Location:2 → 105
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:296 → 400
    Sprouty; Sprouty protein (Spry)

  2. NM_001394336.1 → NP_001381265.1  sprouty-related, EVH1 domain-containing protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC005789
    Consensus CDS
    CCDS42560.1
    UniProtKB/Swiss-Prot
    Q2MJR0, Q2MJR1
    UniProtKB/TrEMBL
    B9EKV1
    Related
    ENSP00000510478.1, ENST00000691638.1
    Conserved Domains (2) summary
    cd10574
    Location:2 → 105
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:296 → 400
    Sprouty; Sprouty protein (Spry)

  3. NM_001394337.1 → NP_001381266.1  sprouty-related, EVH1 domain-containing protein 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC005789
    UniProtKB/TrEMBL
    B9EKV1
    Conserved Domains (1) summary
    cd10574
    Location:2 → 105
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain

  4. NM_001394338.1 → NP_001381267.1  sprouty-related, EVH1 domain-containing protein 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005789

RNA

  1. NR_073032.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005789

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    38388697..38399587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    41190872..41201764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039616.1: Suppressed sequence

    Description
    NM_001039616.1: This RefSeq was suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2MJR0.1 GenPept UniProtKB/Swiss-Prot:Q2MJR0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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