dnaaf11 dynein axonemal assembly factor 11 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnaaf11provided by ZNC
Official Full Name: dynein axonemal assembly factor 11provided by ZNC
Primary source: ZFIN:ZDB-GENE-040827-2
See related: Ensembl:ENSDARG00000053318 AllianceGenome:ZFIN:ZDB-GENE-040827-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lrrc6; lrrc6l
Summary: Acts upstream of or within several processes, including cilium movement involved in cell motility; embryonic morphogenesis; and motile cilium assembly. Located in cytoplasm. Is expressed in several structures, including floor plate; forerunner cell group; olfactory pit; pronephros; and tail bud. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 19. Orthologous to human DNAAF11 (dynein axonemal assembly factor 11). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (43098069..43124049, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (43248680..43274606, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the Reptin-Lrrc6/Seahorse complex is involved in dynein arm formation.
Title: Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility.
the function of seahorse in cilia motility is separable from its function in other cilia-related phenotypes
Title: Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning.
Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways.
Title: Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways.

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General gene information

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Markers

fj07d01.x1 (e-PCR)
- UniSTS:198446

z19822 (e-PCR), detects polymorphism
- UniSTS:239000

G40013 (e-PCR)
- UniSTS:10229

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axonemal dynein complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cerebrospinal fluid circulation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium movement involved in cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of localization in cell	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heart jogging	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in outer dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within outer dynein arm assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to cilium	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to motile cilium	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in dynein axonemal particle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dynein axonemal assembly factor 11; protein tilB homolog

Names: leucine rich repeat containing 6; leucine-rich repeat-containing 6 like; leucine-rich repeat-containing 6-like protein; leucine-rich repeat-containing protein 6; protein TILB homolog; sea; seahorse; unm tg238a; zar; zator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002311.1 → NP_001002311.1 dynein axonemal assembly factor 11

See identical proteins and their annotated locations for NP_001002311.1

Status: PROVISIONAL

Source sequence(s)

AY618925

UniProtKB/Swiss-Prot

B3DH20, Q6IVV9

Related

ENSDARP00000069830.3, ENSDART00000075347.5

Conserved Domains (3) summary

sd00031
Location:23 → 45

LRR_1; leucine-rich repeat [structural motif]

pfam12799
Location:46 → 86

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:46 → 98

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

43098069..43124049 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171374.4 → XP_005171431.1 protein tilB homolog isoform X1

UniProtKB/Swiss-Prot

B3DH20, Q6IVV9

UniProtKB/TrEMBL

A0A8M2BIP4, F1Q7C0

Related

ENSDARP00000113887.1, ENSDART00000132346.3

Conserved Domains (3) summary

sd00031
Location:23 → 45

LRR_1; leucine-rich repeat [structural motif]

pfam12799
Location:46 → 86

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:46 → 98

LRR_8; Leucine rich repeat