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MX1 MX dynamin like GTPase 1 [ Homo sapiens (human) ]

Gene ID: 4599, updated on 10-Dec-2024

Summary

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Official Symbol
MX1provided by HGNC
Official Full Name
MX dynamin like GTPase 1provided by HGNC
Primary source
HGNC:HGNC:7532
See related
Ensembl:ENSG00000157601 MIM:147150; AllianceGenome:HGNC:7532
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MX; MxA; IFI78; IFI-78K; lncMX1-215
Summary
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in spleen (RPKM 25.6), salivary gland (RPKM 13.5) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See MX1 in Genome Data Viewer
Location:
21q22.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (41420558..41459214)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (39807998..39847898)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (42792485..42831141)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18470 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr21:42731293-42732096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42739613-42740114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42740714-42741402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42741403-42742089 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 21:42745414 Neighboring gene melanoma risk locus-associated MPRA allelic enhancers 21:42746568 and 21:42746578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42750497-42750998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42750999-42751498 Neighboring gene MX dynamin like GTPase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18479 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:42824122-42825321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42830117-42830618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42851654-42852154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42852155-42852655 Neighboring gene transmembrane serine protease 2 Neighboring gene transmembrane protease serine 2 breakpoint cluster recombination region Neighboring gene TMPRSS2 promoter region Neighboring gene TMPRSS2 repressive element NBS1 Neighboring gene TMPRSS2 repressive element NBS2 Neighboring gene TMPRSS2 repressive element NBS4 Neighboring gene TMPRSS2 androgen receptor-responsive -13 kb enhancer Neighboring gene TMPRSS2 -17 kb enhancer Neighboring gene TMPRSS2 E3 enhancer Neighboring gene uncharacterized LOC124905021

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Single nucleotide polymorphisms and functional analysis of MxA promoter region in multiple sclerosis. Furuyama H, et al. J Neurol Sci, 2006 Nov 15. PMID 16843495
  2. Use of a standardized MxA protein measurement-based assay for validation of assays for the assessment of neutralizing antibodies against interferon-β. Wadhwa M, et al. J Interferon Cytokine Res, 2013 Nov. PMID 23848523, Free PMC Article
  3. Immunological changes and increased expression of myxovirus resistance protein a in thyroid tissue of patients with recent onset and untreated Graves' disease. Hammerstad SS, et al. Thyroid, 2014 Mar. PMID 24032645
  4. West Nile virus-induced cytoplasmic membrane structures provide partial protection against the interferon-induced antiviral MxA protein. Hoenen A, et al. J Gen Virol, 2007 Nov. PMID 17947524
  5. Interferon-induced Mx proteins in antiviral host defense. Haller O, et al. Biochimie, 2007 Jun-Jul. PMID 17570575

See all (228) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oral Antiviral Defense: Saliva- and Beverage-like Hypotonicity Dynamically Regulate Formation of Membraneless Biomolecular Condensates of Antiviral Human MxA in Oral Epithelial Cells.
    Title: Oral Antiviral Defense: Saliva- and Beverage-like Hypotonicity Dynamically Regulate Formation of Membraneless Biomolecular Condensates of Antiviral Human MxA in Oral Epithelial Cells.
  2. Myxovirus resistance protein A (MxA) expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis.
    Title: Myxovirus resistance protein A (MxA) expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis.
  3. Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19.
    Title: Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19.
  4. Increased expression of human antiviral protein MxA in FUS proteinopathy in amyotrophic lateral sclerosis.
    Title: Increased expression of human antiviral protein MxA in FUS proteinopathy in amyotrophic lateral sclerosis.
  5. Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity.
    Title: Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity.
  6. Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.
    Title: Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.
  7. Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication.
    Title: Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication.
  8. An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses.
    Title: An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses.
  9. Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.
    Title: Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.
  10. Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.
    Title: Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.
Submit: New GeneRIF Correction See all GeneRIFs (157)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 replication is restricted by wild type MX1 (MxA); restriction is dependent on amino acids M527 in MX1 as assayed in U87-MG CD4+ CXCR4+ cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of MX dynamin-like GTPase 1 (MX1; MxA; IFI78) in immature dendritic cells and monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including MX1, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of MX1 in human monocyte-derived dendritic cells PubMed
vpr HIV-1 Vpr upregulates the gene expression of MX1 in human monocyte-derived macrophages PubMed
vpr HIV-1 Vpr downregulates MX1 expression in human glial cells PubMed
Vpu vpu The expression of MX1 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in antiviral innate immune response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in interleukin-27-mediated signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to type I interferon TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon-induced GTP-binding protein Mx1
Names
interferon-induced protein p78
interferon-inducible protein p78
interferon-regulated resistance GTP-binding protein MxA
myxoma resistance protein 1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027788.2 RefSeqGene

    Range
    10647..43620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144925.2 → NP_001138397.1  interferon-induced GTP-binding protein Mx1 isoform a

    See identical proteins and their annotated locations for NP_001138397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as T0) represents the longest transcript and encodes isoform a. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AK096355, BC032602, DA726666, EB388095, M33882
    Consensus CDS
    CCDS13673.1
    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000381601.2, ENST00000398600.6
    Conserved Domains (3) summary
    smart00302
    Location:571 → 660
    GED; Dynamin GTPase effector domain
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:260 → 546
    Dynamin_M; Dynamin central region

  2. NM_001178046.3 → NP_001171517.1  interferon-induced GTP-binding protein Mx1 isoform a

    See identical proteins and their annotated locations for NP_001171517.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks five exons and contains an alternate terminal exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AK315465, BC032602, EB388095, M33882
    Consensus CDS
    CCDS13673.1
    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000410523.2, ENST00000455164.6
    Conserved Domains (3) summary
    smart00302
    Location:571 → 660
    GED; Dynamin GTPase effector domain
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:260 → 546
    Dynamin_M; Dynamin central region

  3. NM_001282920.1 → NP_001269849.1  interferon-induced GTP-binding protein Mx1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks three exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b, also known as varMxA) is shorter and has a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID: 20603636.
    Source sequence(s)
    BC032602, EB388095, M33882
    Consensus CDS
    CCDS74796.1
    UniProtKB/TrEMBL
    A0A7P0Z4E0
    Related
    ENSP00000478441.1, ENST00000619682.1
    Conserved Domains (3) summary
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:130 → 357
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:261 → 424
    Dynamin_M; Dynamin central region

  4. NM_002462.5 → NP_002453.2  interferon-induced GTP-binding protein Mx1 isoform a

    See identical proteins and their annotated locations for NP_002453.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as T1) lacks three exons and contains an alternate terminal exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    BC032602, EB388095, M33882
    Consensus CDS
    CCDS13673.1
    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000381599.3, ENST00000398598.8
    Conserved Domains (3) summary
    smart00302
    Location:571 → 660
    GED; Dynamin GTPase effector domain
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:260 → 546
    Dynamin_M; Dynamin central region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    41420558..41459214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028349.3 → XP_016883838.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Conserved Domains (3) summary
    smart00302
    Location:571 → 660
    GED; Dynamin GTPase effector domain
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:260 → 546
    Dynamin_M; Dynamin central region

  2. XM_047440771.1 → XP_047296727.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1, H9KVC7

  3. XM_047440769.1 → XP_047296725.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000505657.1, ENST00000681191.1

  4. XM_011529568.3 → XP_011527870.1  interferon-induced GTP-binding protein Mx1 isoform X1

    See identical proteins and their annotated locations for XP_011527870.1

    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Conserved Domains (3) summary
    smart00302
    Location:571 → 660
    GED; Dynamin GTPase effector domain
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:260 → 546
    Dynamin_M; Dynamin central region

  5. XM_047440765.1 → XP_047296721.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000506183.1, ENST00000680347.1

  6. XM_047440766.1 → XP_047296722.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000506062.1, ENST00000681415.1

  7. XM_047440767.1 → XP_047296723.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000506395.1, ENST00000680182.1

  8. XM_047440768.1 → XP_047296724.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000506220.1, ENST00000681039.1

  9. XM_047440770.1 → XP_047296726.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000506712.1, ENST00000681671.1

  10. XM_005260978.5 → XP_005261035.1  interferon-induced GTP-binding protein Mx1 isoform X1

    See identical proteins and their annotated locations for XP_005261035.1

    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000506512.1, ENST00000680776.1
    Conserved Domains (3) summary
    smart00302
    Location:571 → 660
    GED; Dynamin GTPase effector domain
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:260 → 546
    Dynamin_M; Dynamin central region

  11. XM_017028352.2 → XP_016883841.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1, H9KVC7
    Related
    ENSP00000505269.1, ENST00000679408.1
    Conserved Domains (4) summary
    smart00302
    Location:518 → 607
    GED; Dynamin GTPase effector domain
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:130 → 357
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:261 → 493
    Dynamin_M; Dynamin central region

  12. XM_005260980.3 → XP_005261037.1  interferon-induced GTP-binding protein Mx1 isoform X1

    See identical proteins and their annotated locations for XP_005261037.1

    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000506348.1, ENST00000681266.1
    Conserved Domains (3) summary
    smart00302
    Location:571 → 660
    GED; Dynamin GTPase effector domain
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:260 → 546
    Dynamin_M; Dynamin central region

  13. XM_047440772.1 → XP_047296728.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1, H9KVC7

  14. XM_017028351.3 → XP_016883840.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1, H9KVC7
    Related
    ENSP00000400923.2, ENST00000424365.6
    Conserved Domains (4) summary
    smart00302
    Location:518 → 607
    GED; Dynamin GTPase effector domain
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:130 → 357
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:261 → 493
    Dynamin_M; Dynamin central region

  15. XM_005260982.3 → XP_005261039.1  interferon-induced GTP-binding protein Mx1 isoform X1

    See identical proteins and their annotated locations for XP_005261039.1

    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000402215.2, ENST00000417963.6
    Conserved Domains (3) summary
    smart00302
    Location:571 → 660
    GED; Dynamin GTPase effector domain
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:260 → 546
    Dynamin_M; Dynamin central region

  16. XM_047440774.1 → XP_047296730.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1, H9KVC7

  17. XM_005260981.3 → XP_005261038.1  interferon-induced GTP-binding protein Mx1 isoform X1

    See identical proteins and their annotated locations for XP_005261038.1

    UniProtKB/Swiss-Prot
    B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
    UniProtKB/TrEMBL
    F8W8T1
    Related
    ENSP00000505051.1, ENST00000681849.1
    Conserved Domains (3) summary
    smart00302
    Location:571 → 660
    GED; Dynamin GTPase effector domain
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:260 → 546
    Dynamin_M; Dynamin central region

  18. XM_047440773.1 → XP_047296729.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1, H9KVC7

  19. XM_047440776.1 → XP_047296732.1  interferon-induced GTP-binding protein Mx1 isoform X3

    UniProtKB/TrEMBL
    A0A7P0Z4E0

  20. XM_047440777.1 → XP_047296733.1  interferon-induced GTP-binding protein Mx1 isoform X3

    UniProtKB/TrEMBL
    A0A7P0Z4E0

  21. XM_047440775.1 → XP_047296731.1  interferon-induced GTP-binding protein Mx1 isoform X3

    UniProtKB/TrEMBL
    A0A7P0Z4E0

  22. XM_047440778.1 → XP_047296734.1  interferon-induced GTP-binding protein Mx1 isoform X3

    UniProtKB/TrEMBL
    A0A7P0Z4E0

  23. XM_011529570.4 → XP_011527872.1  interferon-induced GTP-binding protein Mx1 isoform X3

    UniProtKB/TrEMBL
    A0A7P0Z4E0
    Conserved Domains (3) summary
    cd08771
    Location:68 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:130 → 357
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:261 → 425
    Dynamin_M; Dynamin central region

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    39807998..39847898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324489.1 → XP_054180464.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  2. XM_054324474.1 → XP_054180449.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  3. XM_054324494.1 → XP_054180469.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1

  4. XM_054324488.1 → XP_054180463.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  5. XM_054324490.1 → XP_054180465.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  6. XM_054324487.1 → XP_054180462.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  7. XM_054324493.1 → XP_054180468.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1

  8. XM_054324483.1 → XP_054180458.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  9. XM_054324492.1 → XP_054180467.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1

  10. XM_054324470.1 → XP_054180445.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  11. XM_054324481.1 → XP_054180456.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  12. XM_054324478.1 → XP_054180453.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  13. XM_054324473.1 → XP_054180448.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  14. XM_054324475.1 → XP_054180450.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  15. XM_054324484.1 → XP_054180459.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  16. XM_054324476.1 → XP_054180451.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  17. XM_054324471.1 → XP_054180446.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  18. XM_054324482.1 → XP_054180457.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  19. XM_054324495.1 → XP_054180470.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1

  20. XM_054324500.1 → XP_054180475.1  interferon-induced GTP-binding protein Mx1 isoform X3

    UniProtKB/TrEMBL
    A0A7P0Z4E0

  21. XM_054324480.1 → XP_054180455.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  22. XM_054324496.1 → XP_054180471.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1

  23. XM_054324491.1 → XP_054180466.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1

  24. XM_054324486.1 → XP_054180461.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  25. XM_054324498.1 → XP_054180473.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1

  26. XM_054324472.1 → XP_054180447.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  27. XM_054324497.1 → XP_054180472.1  interferon-induced GTP-binding protein Mx1 isoform X2

    UniProtKB/TrEMBL
    F8W8T1

  28. XM_054324501.1 → XP_054180476.1  interferon-induced GTP-binding protein Mx1 isoform X3

    UniProtKB/TrEMBL
    A0A7P0Z4E0

  29. XM_054324499.1 → XP_054180474.1  interferon-induced GTP-binding protein Mx1 isoform X3

    UniProtKB/TrEMBL
    A0A7P0Z4E0

  30. XM_054324503.1 → XP_054180478.1  interferon-induced GTP-binding protein Mx1 isoform X3

    UniProtKB/TrEMBL
    A0A7P0Z4E0

  31. XM_054324502.1 → XP_054180477.1  interferon-induced GTP-binding protein Mx1 isoform X3

    UniProtKB/TrEMBL
    A0A7P0Z4E0

  32. XM_054324477.1 → XP_054180452.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  33. XM_054324479.1 → XP_054180454.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1

  34. XM_054324485.1 → XP_054180460.1  interferon-induced GTP-binding protein Mx1 isoform X1

    UniProtKB/TrEMBL
    F8W8T1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20591.4 GenPept UniProtKB/Swiss-Prot:P20591

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