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REX1BD required for excision 1-B domain containing [ Homo sapiens (human) ]

Gene ID: 55049, updated on 27-Nov-2024

Summary

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Official Symbol
REX1BDprovided by HGNC
Official Full Name
required for excision 1-B domain containingprovided by HGNC
Primary source
HGNC:HGNC:26098
See related
Ensembl:ENSG00000006015 AllianceGenome:HGNC:26098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C19orf60
Expression
Ubiquitous expression in fat (RPKM 15.5), spleen (RPKM 13.5) and 23 other tissues See more
Orthologs
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Genomic context

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See REX1BD in Genome Data Viewer
Location:
19p13.11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (18588798..18592337)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (18723873..18727404)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18699608..18703147)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11651 Neighboring gene FKBP prolyl isomerase 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18652136-18652636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10407 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18667707-18668498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18668499-18669288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18672913-18673498 Neighboring gene KxDL motif containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18682001-18682677 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18683356-18684032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18702459-18702982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18703866-18704367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10411 Neighboring gene Sharpr-MPRA regulatory region 11645 Neighboring gene cytokine receptor like factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18716731-18717649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18724873-18725393 Neighboring gene transmembrane protein 59 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Heterochromatin repeat organization at an individual level: Rex1BD and the 14-3-3 protein coordinate to shape the epigenetic landscape within heterochromatin repeats. Gao J, et al. Bioessays, 2024 Jul. PMID 38679759
  2. REX1, a novel gene required for DNA repair. Cenkci B, et al. J Biol Chem, 2003 Jun 20. PMID 12697762
  3. A novel human protein is able to interact with hepatitis B virus core deletion mutant but not with the wild-type protein. Razanskas R, et al. Virus Res, 2009 Dec. PMID 19770013
  4. Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications. Salguero AL, et al. ACS Chem Biol, 2022 Jan 21. PMID 34941261, Free PMC Article
  5. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Heterochromatin repeat organization at an individual level: Rex1BD and the 14-3-3 protein coordinate to shape the epigenetic landscape within heterochromatin repeats.
    Title: Heterochromatin repeat organization at an individual level: Rex1BD and the 14-3-3 protein coordinate to shape the epigenetic landscape within heterochromatin repeats.
  2. A human protein of unknown function FLJ20850 interacted specifically with deletion mutant hepatitis B core proteins.
    Title: A novel human protein is able to interact with hepatitis B virus core deletion mutant but not with the wild-type protein.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20850, FLJ30108, FLJ34606, FLJ37391

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
required for excision 1-B domain-containing protein
Names
uncharacterized protein C19orf60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100418.2 → NP_001093888.1  required for excision 1-B domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001093888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    BC012078
    Consensus CDS
    CCDS42524.1
    UniProtKB/Swiss-Prot
    E9PAS0, Q8NAX4, Q96EN9, Q9NWI0
    UniProtKB/TrEMBL
    A0A0B4U845
    Related
    ENSP00000351422.5, ENST00000358607.11
    Conserved Domains (1) summary
    pfam14966
    Location:40 → 157
    DNA_repr_REX1B; DNA repair REX1-B

  2. NM_001100419.2 → NP_001093889.1  required for excision 1-B domain-containing protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BC012078, BI836487, DB254892
    Consensus CDS
    CCDS46019.1
    UniProtKB/TrEMBL
    A0A0B4U845
    Related
    ENSP00000398467.1, ENST00000450195.6
    Conserved Domains (1) summary
    pfam14966
    Location:40 → 135
    DNA_repr_REX1B; DNA repair REX1-B

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    18588798..18592337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439026.1 → XP_047294982.1  required for excision 1-B domain-containing protein isoform X1

    Related
    ENST00000597371.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    18723873..18727404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321347.1 → XP_054177322.1  required for excision 1-B domain-containing protein isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017967.2: Suppressed sequence

    Description
    NM_017967.2: This RefSeq was permanently suppressed because it contains the wrong CDS, and the correct CDS would make it a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96EN9.1 GenPept UniProtKB/Swiss-Prot:Q96EN9

Gene LinkOut

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