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PPP2R1B protein phosphatase 2 scaffold subunit Abeta [ Homo sapiens (human) ]

Gene ID: 5519, updated on 14-Nov-2024

Summary

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Official Symbol
PPP2R1Bprovided by HGNC
Official Full Name
protein phosphatase 2 scaffold subunit Abetaprovided by HGNC
Primary source
HGNC:HGNC:9303
See related
Ensembl:ENSG00000137713 MIM:603113; AllianceGenome:HGNC:9303
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR65B; PP2A-Abeta
Summary
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in testis (RPKM 13.7), fat (RPKM 13.4) and 25 other tissues See more
Orthologs
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Genomic context

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See PPP2R1B in Genome Data Viewer
Location:
11q23.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (111688000..111766389, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (111698152..111776539, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111597637..111637113, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111410548-111411227 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:111424938-111426137 Neighboring gene Sharpr-MPRA regulatory region 3081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:111435687-111436190 Neighboring gene layilin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3898 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3899 Neighboring gene salt inducible kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111563346-111563859 Neighboring gene RN7SK pseudogene 273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111594031-111594566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111603371-111604187 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:111605768-111606404 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:111636139-111637042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3900 Neighboring gene uncharacterized LOC124902756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3901 Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:111685391-111686590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111709725-111710226 Neighboring gene G protein subunit gamma 5 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas. Hemmer S, et al. Cancer Genet Cytogenet, 2002 Apr 1. PMID 11996789
  2. Lnc-PPP2R1B Mediates the Alternative Splicing of PPP2R1B by Interacting and Stabilizing HNRNPLL and Promotes Osteogenesis of MSCs. Peng S, et al. Stem Cell Rev Rep, 2023 Aug. PMID 37243830
  3. Chromosome 11q23.1 is an unstable region in B-cell tumor cell lines. Poretti G, et al. Leuk Res, 2011 Jun. PMID 21420167
  4. PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis. Grinthal A, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133745, Free PMC Article
  5. Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer. Yeh LS, et al. Int J Gynecol Cancer, 2007 Jul-Aug. PMID 17343570

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lnc-PPP2R1B Mediates the Alternative Splicing of PPP2R1B by Interacting and Stabilizing HNRNPLL and Promotes Osteogenesis of MSCs.
    Title: Lnc-PPP2R1B Mediates the Alternative Splicing of PPP2R1B by Interacting and Stabilizing HNRNPLL and Promotes Osteogenesis of MSCs.
  2. PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis.
    Title: PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis.
  3. MicroRNA-587 antagonizes 5-fluorouracil-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer.
    Title: MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer.
  4. For PPP2R1B, no mutations were detected in our samples.
    Title: Infrequent mutations of the PPP2R1A and PPP2R1B genes in patients with ovarian cancer.
  5. Data show that the only gene that was expressed, although not at high levels, in all the cells carrying the 11q23.1 amplification was PPP2R1B.
    Title: Chromosome 11q23.1 is an unstable region in B-cell tumor cell lines.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. Data show that PR65-dominated fluctuations of PP2A have the effect of opening and closing the enzyme's substrate binding/catalysis interface, as well as altering the positions of certain catalytic residues.
    Title: PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis.
  8. Data show that upon hypoxia, the TGF-beta-induced phosphorylation of Smad3 was inhibited, although Smad2 remained phosphorylated, and Smad3 was dephosphorylated by PP2A.
    Title: Hypoxia-activated Smad3-specific dephosphorylation by PP2A.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.
  10. PPP2R1B genes may not play a role in the carcinogenesis of cervical cancer. Mutations of PPP2R1B gene are not frequent in cervical cancer.
    Title: Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Lung cancer
MedGen: C0242379 OMIM: 211980 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of serine/threonine protein phosphatase 2A (65 kDa regulatory subunit A) in T-cell lines PubMed
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat HIV-1 Tat associates with the promoters of both PPP2R1B and PPP2R5E to increase PPP2R1B and PPP2R5E RNA and protein levels as well as PP2A activity in Jurkat T cells PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26454

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic sister chromatid cohesion, centromeric IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Names
protein phosphatase 2, regulatory subunit A, beta
protein phosphatase 2, structural/regulatory subunit A, beta
NP_001171033.1
NP_001171034.1
NP_002707.3
NP_859050.1
NP_859051.1
XP_016873449.1
XP_024304368.1
XP_047283145.1
XP_047283146.1
XP_047283147.1
XP_047283148.1
XP_047283149.1
XP_047283150.1
XP_047283151.1
XP_047283152.1
XP_054225214.1
XP_054225215.1
XP_054225216.1
XP_054225217.1
XP_054225218.1
XP_054225219.1
XP_054225220.1
XP_054225221.1
XP_054225222.1
XP_054225223.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012117.3 RefSeqGene

    Range
    5000..33512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177562.2 → NP_001171033.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the coding region compared to variant 1. The resulting isoform (d) is shorter than isoform a.
    Source sequence(s)
    AF163473, AK294716, AP000925, AP001781, DC402587
    Consensus CDS
    CCDS53708.1
    UniProtKB/Swiss-Prot
    P30154
    Related
    ENSP00000343317.6, ENST00000341980.10
    Conserved Domains (3) summary
    pfam13646
    Location:217 → 315
    HEAT_2; HEAT repeats
    sd00044
    Location:257 → 281
    HEAT; HEAT repeat [structural motif]
    cl21454
    Location:363 → 421
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001177563.2 → NP_001171034.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the 5' coding region compared to variant 1. The resulting isoform (e) is shorter than isoform a.
    Source sequence(s)
    AF163473, AK296455, AP000925, DC402587
    Consensus CDS
    CCDS53707.1
    UniProtKB/Swiss-Prot
    P30154
    Related
    ENSP00000376775.2, ENST00000393055.6
    Conserved Domains (4) summary
    COG1413
    Location:115 → 347
    HEAT; HEAT repeat [General function prediction only]
    pfam13646
    Location:374 → 469
    HEAT_2; HEAT repeats
    sd00044
    Location:130 → 154
    HEAT; HEAT repeat [structural motif]
    cl21454
    Location:281 → 339
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. NM_002716.5 → NP_002707.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a

    See identical proteins and their annotated locations for NP_002707.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AF163473, AP000925, BC027596
    Consensus CDS
    CCDS8349.1
    UniProtKB/Swiss-Prot
    A8MY67, B0YJ69, B4DGQ6, B4DK91, B4DWW5, F8W8G1, O75620, P30154, Q8NHV8
    UniProtKB/TrEMBL
    A8K8B0
    Related
    ENSP00000437193.1, ENST00000527614.6
    Conserved Domains (3) summary
    pfam13646
    Location:217 → 315
    HEAT_2; HEAT repeats
    sd00044
    Location:257 → 281
    HEAT; HEAT repeat [structural motif]
    cl21454
    Location:408 → 466
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. NM_181699.3 → NP_859050.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b

    See identical proteins and their annotated locations for NP_859050.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (b) contains a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AF087438, AP001781, BC027596, DB527885
    Consensus CDS
    CCDS8348.1
    UniProtKB/TrEMBL
    A8K8B0
    Related
    ENSP00000311344.5, ENST00000311129.9
    Conserved Domains (4) summary
    pfam13513
    Location:191 → 240
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:217 → 316
    HEAT_2; HEAT repeats
    sd00044
    Location:257 → 281
    HEAT; HEAT repeat [structural motif]
    cl21454
    Location:408 → 466
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  5. NM_181700.2 → NP_859051.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform c

    See identical proteins and their annotated locations for NP_859051.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the 5' coding region and differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (c) contains a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK301705, DB527885, DC402587
    Consensus CDS
    CCDS53706.1
    UniProtKB/TrEMBL
    A8K8B0
    Related
    ENSP00000410671.2, ENST00000426998.6
    Conserved Domains (5) summary
    pfam02985
    Location:231 → 261
    HEAT; HEAT repeat
    pfam13513
    Location:127 → 176
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:153 → 252
    HEAT_2; HEAT repeats
    sd00044
    Location:193 → 217
    HEAT; HEAT repeat [structural motif]
    cl21454
    Location:344 → 402
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    111688000..111766389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448600.2 → XP_024304368.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4

    Conserved Domains (2) summary
    COG1413
    Location:177 → 392
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:257 → 281
    HEAT; HEAT repeat [structural motif]

  2. XM_047427193.1 → XP_047283149.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

  3. XM_047427194.1 → XP_047283150.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

  4. XM_047427195.1 → XP_047283151.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

  5. XM_047427191.1 → XP_047283147.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

  6. XM_047427190.1 → XP_047283146.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

  7. XM_047427192.1 → XP_047283148.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

  8. XM_047427189.1 → XP_047283145.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

  9. XM_017017960.2 → XP_016873449.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3

  10. XM_047427196.1 → XP_047283152.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    111698152..111776539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369247.1 → XP_054225222.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4

  2. XM_054369243.1 → XP_054225218.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

  3. XM_054369244.1 → XP_054225219.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

  4. XM_054369245.1 → XP_054225220.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

  5. XM_054369241.1 → XP_054225216.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

  6. XM_054369240.1 → XP_054225215.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

  7. XM_054369242.1 → XP_054225217.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

  8. XM_054369239.1 → XP_054225214.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

  9. XM_054369246.1 → XP_054225221.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3

  10. XM_054369248.1 → XP_054225223.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30154.3 GenPept UniProtKB/Swiss-Prot:P30154

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