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Ltbp2 latent transforming growth factor beta binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59106, updated on 10-Jul-2024

Summary

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Official Symbol
Ltbp2provided by RGD
Official Full Name
latent transforming growth factor beta binding protein 2provided by RGD
Primary source
RGD:68380
See related
EnsemblRapid:ENSRNOG00000012094 AllianceGenome:RGD:68380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable microfibril binding activity. Predicted to be involved in supramolecular fiber organization. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human LTBP2 (latent transforming growth factor beta binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 323.1), Heart (RPKM 60.0) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ltbp2 in Genome Data Viewer
Location:
6q31
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110161029..110261586, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104429947..104530498, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108500114..108596653, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene NPC intracellular cholesterol transporter 2 Neighboring gene iron-sulfur cluster assembly 2 Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene Fcf1 rRNA-processing protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure. Park S, et al. JACC Basic Transl Sci, 2020 May. PMID 32478206, Free PMC Article
  2. LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy. Pang XF, et al. Acta Physiol (Oxf), 2020 Mar. PMID 31512380
  3. Identification of differentially expressed genes and preliminary validations in cardiac pathological remodeling induced by transverse aortic constriction. Wang HB, et al. Int J Mol Med, 2019 Oct. PMID 31364721, Free PMC Article
  4. Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities. Potus F, et al. Int J Mol Sci, 2018 Sep 12. PMID 30213070, Free PMC Article
  5. Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis. Park S, et al. Circulation, 2018 Sep 18. PMID 29950403, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy.
    Title: LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy.
  2. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
    Title: Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables microfibril binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in response to alkaloid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in supramolecular fiber organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in supramolecular fiber organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within supramolecular fiber organization ISO
Inferred from Sequence Orthology
more info
  
involved_in transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
latent-transforming growth factor beta-binding protein 2
Names
LTBP-2 like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021586.2 → NP_067597.2  latent-transforming growth factor beta-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    CK358810, CK479508, DV213994, Y12760
    UniProtKB/TrEMBL
    A6JDY9, F1M7L7
    Related
    ENSRNOP00000038437.3, ENSRNOT00000031331.6
    Conserved Domains (4) summary
    smart00179
    Location:1269 → 1302
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:897 → 931
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00683
    Location:689 → 725
    TB; TB domain
    pfam07645
    Location:1145 → 1184
    EGF_CA; Calcium-binding EGF domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    110161029..110261586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240350.5 → XP_006240412.1  latent-transforming growth factor beta-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006240412.1

    UniProtKB/TrEMBL
    A0A0G2K1G5, A0A8I6A5Z7, A6JDZ0
    Related
    ENSRNOP00000071831.1, ENSRNOT00000082792.3
    Conserved Domains (4) summary
    smart00179
    Location:1313 → 1346
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:897 → 931
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00683
    Location:1433 → 1468
    TB; TB domain
    pfam07645
    Location:1145 → 1184
    EGF_CA; Calcium-binding EGF domain

  2. XM_039112809.2 → XP_038968737.1  latent-transforming growth factor beta-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A5Z7
    Conserved Domains (5) summary
    smart00179
    Location:1272 → 1305
    EGF_CA; Calcium-binding EGF-like domain
    PHA03378
    Location:756 → 854
    PHA03378; EBNA-3B; Provisional
    cd00054
    Location:897 → 931
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:1104 → 1143
    EGF_CA; Calcium-binding EGF domain
    pfam00683
    Location:689 → 731
    TB; TB domain

  3. XM_039112808.2 → XP_038968736.1  latent-transforming growth factor beta-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A6JDY9, F1M7L7
    Conserved Domains (5) summary
    smart00179
    Location:1272 → 1305
    EGF_CA; Calcium-binding EGF-like domain
    PHA03378
    Location:756 → 854
    PHA03378; EBNA-3B; Provisional
    cd00054
    Location:897 → 931
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:1061 → 1101
    EGF_CA; Calcium-binding EGF domain
    pfam00683
    Location:689 → 731
    TB; TB domain

  4. XM_063262384.1 → XP_063118454.1  latent-transforming growth factor beta-binding protein 2 isoform X5

    UniProtKB/TrEMBL
    A6JDY9, F1M7L7
    Related
    ENSRNOP00000106048.1, ENSRNOT00000127640.1

  5. XM_063262382.1 → XP_063118452.1  latent-transforming growth factor beta-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2KAU7
    Related
    ENSRNOP00000075533.2, ENSRNOT00000077458.3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35806.1 GenPept UniProtKB/Swiss-Prot:O35806

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