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SLCO1A2 solute carrier organic anion transporter family member 1A2 [ Homo sapiens (human) ]

Gene ID: 6579, updated on 2-Nov-2024

Summary

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Official Symbol
SLCO1A2provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 1A2provided by HGNC
Primary source
HGNC:HGNC:10956
See related
Ensembl:ENSG00000084453 MIM:602883; AllianceGenome:HGNC:10956
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OATP; OATP-A; OATP1A2; SLC21A3
Summary
This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Expression
Biased expression in brain (RPKM 6.2), lung (RPKM 0.9) and 2 other tissues See more
Orthologs
all
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Genomic context

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See SLCO1A2 in Genome Data Viewer
Location:
12p12.1
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (21264600..21419634, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (21143252..21298332, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (21417534..21572568, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family member 1B1 Neighboring gene uncharacterized LOC124903123 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:21386467-21387666 Neighboring gene uncharacterized LOC124902895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:21402494-21402994 Neighboring gene NANOG hESC enhancer GRCh37_chr12:21477387-21477904 Neighboring gene NANOG hESC enhancer GRCh37_chr12:21491840-21492346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21546997-21547930 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21547931-21548862 Neighboring gene islet amyloid polypeptide Neighboring gene NANOG hESC enhancer GRCh37_chr12:21569666-21570167 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21572391-21572952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6087 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene elongin C pseudogene 31 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6090 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21654373-21655080 Neighboring gene RecQ like helicase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. Lee W, et al. J Biol Chem, 2005 Mar 11. PMID 15632119
  2. Hydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier. Cheng Z, et al. Xenobiotica, 2012 Sep. PMID 22509823
  3. Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions. Arakawa H, et al. Biochem Pharmacol, 2012 Oct 15. PMID 22864060
  4. The SLCO1A2 gene, encoding human organic anion-transporting polypeptide 1A2, is transactivated by the vitamin D receptor. Eloranta JJ, et al. Mol Pharmacol, 2012 Jul. PMID 22474172
  5. Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2. Zhou F, et al. AAPS J, 2013 Oct. PMID 23918469, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1.
    Title: The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1.
  2. Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants.
    Title: Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants.
  3. Pharmacogenomics of celiprolol - evidence for a role of P-glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics.
    Title: Pharmacogenomics of celiprolol - evidence for a role of P-glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics.
  4. Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis.
    Title: Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis.
  5. SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma.
    Title: SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma.
  6. Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment.
    Title: Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment.
  7. Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone.
    Title: Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone.
  8. In the regulation of the function and expression of OATP1A2.
    Title: The 5'-AMP-Activated Protein Kinase Regulates the Function and Expression of Human Organic Anion Transporting Polypeptide 1A2.
  9. These results indicate that the SLCO1A2 rs4149009 G > A polymorphism might affect MTX pharmacokinetics by interfering with the function of miRNAs.
    Title: Association between a microRNA binding site polymorphism in SLCO1A2 and the risk of delayed methotrexate elimination in Chinese children with acute lymphoblastic leukemia.
  10. Our findings uncover novel associations of progressive supranuclear palsy with SLCO1A2 (rs11568563) and DUSP10 (rs6687758) variants
    Title: Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association meta-analysis for total serum bilirubin levels.
EBI GWAS Catalog
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
EBI GWAS Catalog
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bile acid transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables organic cation transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bile acid and bile salt transport TAS
Traceable Author Statement
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organic anion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in organic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium-independent organic anion transport TAS
Traceable Author Statement
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane TAS
Traceable Author Statement
more info
  
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
solute carrier organic anion transporter family member 1A2
Names
OATP-1
organic anion transporting polypeptide A
organic anion-transporting polypeptide 1
sodium-independent organic anion transporter
solute carrier family 21 (organic anion transporter), member 3
solute carrier family 21 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386878.1 → NP_001373807.1  solute carrier organic anion transporter family member 1A2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC006559, AC022224
    Consensus CDS
    CCDS8686.1
    UniProtKB/Swiss-Prot
    P46721, Q9UGP7
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  2. NM_001386879.1 → NP_001373808.1  solute carrier organic anion transporter family member 1A2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Consensus CDS
    CCDS8686.1
    UniProtKB/Swiss-Prot
    P46721, Q9UGP7
    UniProtKB/TrEMBL
    B7ZAD4
    Related
    ENSP00000508235.1, ENST00000683939.1
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  3. NM_001386880.1 → NP_001373809.1  solute carrier organic anion transporter family member 1A2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Consensus CDS
    CCDS8686.1
    UniProtKB/Swiss-Prot
    P46721, Q9UGP7
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  4. NM_001386881.1 → NP_001373810.1  solute carrier organic anion transporter family member 1A2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC006559, AC022224
    Consensus CDS
    CCDS8686.1
    UniProtKB/Swiss-Prot
    P46721, Q9UGP7
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  5. NM_001386882.2 → NP_001373811.1  solute carrier organic anion transporter family member 1A2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Consensus CDS
    CCDS8686.1
    UniProtKB/Swiss-Prot
    P46721, Q9UGP7
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  6. NM_001386886.1 → NP_001373815.1  solute carrier organic anion transporter family member 1A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    cl28910
    Location:18 → 536
    MFS; Major Facilitator Superfamily

  7. NM_001386887.1 → NP_001373816.1  solute carrier organic anion transporter family member 1A2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:18 → 538
    MFS; Major Facilitator Superfamily

  8. NM_001386890.1 → NP_001373819.1  solute carrier organic anion transporter family member 1A2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 469
    oat; sodium-independent organic anion transporter

  9. NM_001386908.1 → NP_001373837.1  solute carrier organic anion transporter family member 1A2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 538
    oat; sodium-independent organic anion transporter

  10. NM_001386919.1 → NP_001373848.1  solute carrier organic anion transporter family member 1A2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 538
    oat; sodium-independent organic anion transporter

  11. NM_001386920.1 → NP_001373849.1  solute carrier organic anion transporter family member 1A2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 469
    oat; sodium-independent organic anion transporter

  12. NM_001386921.1 → NP_001373850.1  solute carrier organic anion transporter family member 1A2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 525
    oat; sodium-independent organic anion transporter

  13. NM_001386922.1 → NP_001373851.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Consensus CDS
    CCDS91662.1
    UniProtKB/TrEMBL
    B4DJE6, B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 493
    oat; sodium-independent organic anion transporter

  14. NM_001386926.1 → NP_001373855.1  solute carrier organic anion transporter family member 1A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    cl28910
    Location:18 → 536
    MFS; Major Facilitator Superfamily

  15. NM_001386927.1 → NP_001373856.1  solute carrier organic anion transporter family member 1A2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 538
    oat; sodium-independent organic anion transporter

  16. NM_001386929.1 → NP_001373858.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Consensus CDS
    CCDS91662.1
    UniProtKB/TrEMBL
    B4DJE6, B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 493
    oat; sodium-independent organic anion transporter

  17. NM_001386931.1 → NP_001373860.1  solute carrier organic anion transporter family member 1A2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 469
    oat; sodium-independent organic anion transporter

  18. NM_001386937.1 → NP_001373866.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC006559, AC022224
    Consensus CDS
    CCDS91662.1
    UniProtKB/TrEMBL
    B4DJE6, B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 493
    oat; sodium-independent organic anion transporter

  19. NM_001386938.1 → NP_001373867.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Consensus CDS
    CCDS91662.1
    UniProtKB/TrEMBL
    B4DJE6, B7ZAD4
    Related
    ENSP00000394854.1, ENST00000458504.5
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 493
    oat; sodium-independent organic anion transporter

  20. NM_001386939.1 → NP_001373868.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Consensus CDS
    CCDS91662.1
    UniProtKB/TrEMBL
    B4DJE6, B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 493
    oat; sodium-independent organic anion transporter

  21. NM_001386940.1 → NP_001373869.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Consensus CDS
    CCDS91662.1
    UniProtKB/TrEMBL
    B4DJE6, B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 493
    oat; sodium-independent organic anion transporter

  22. NM_001386946.1 → NP_001373875.1  solute carrier organic anion transporter family member 1A2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    cl28910
    Location:1 → 518
    MFS; Major Facilitator Superfamily

  23. NM_001386947.1 → NP_001373876.1  solute carrier organic anion transporter family member 1A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    cl28910
    Location:18 → 536
    MFS; Major Facilitator Superfamily

  24. NM_001386948.1 → NP_001373877.1  solute carrier organic anion transporter family member 1A2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    cl28910
    Location:1 → 518
    MFS; Major Facilitator Superfamily

  25. NM_001386949.1 → NP_001373878.1  solute carrier organic anion transporter family member 1A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    cl28910
    Location:18 → 536
    MFS; Major Facilitator Superfamily

  26. NM_001386951.1 → NP_001373880.1  solute carrier organic anion transporter family member 1A2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    cl28910
    Location:1 → 517
    MFS; Major Facilitator Superfamily

  27. NM_001386952.1 → NP_001373881.1  solute carrier organic anion transporter family member 1A2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    cl28910
    Location:1 → 518
    MFS; Major Facilitator Superfamily

  28. NM_001386953.1 → NP_001373882.1  solute carrier organic anion transporter family member 1A2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 469
    oat; sodium-independent organic anion transporter

  29. NM_001386954.1 → NP_001373883.1  solute carrier organic anion transporter family member 1A2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 469
    oat; sodium-independent organic anion transporter

  30. NM_001386958.1 → NP_001373887.1  solute carrier organic anion transporter family member 1A2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:1 → 518
    MFS; Major Facilitator Superfamily

  31. NM_001386959.1 → NP_001373888.1  solute carrier organic anion transporter family member 1A2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    cl28910
    Location:1 → 518
    MFS; Major Facilitator Superfamily

  32. NM_001386960.1 → NP_001373889.1  solute carrier organic anion transporter family member 1A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    cl28910
    Location:18 → 536
    MFS; Major Facilitator Superfamily

  33. NM_001386961.1 → NP_001373890.1  solute carrier organic anion transporter family member 1A2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 469
    oat; sodium-independent organic anion transporter

  34. NM_001386962.1 → NP_001373891.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Consensus CDS
    CCDS91662.1
    UniProtKB/TrEMBL
    B4DJE6, B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 493
    oat; sodium-independent organic anion transporter

  35. NM_001386963.1 → NP_001373892.1  solute carrier organic anion transporter family member 1A2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022224
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    cl28910
    Location:1 → 451
    MFS; Major Facilitator Superfamily

  36. NM_021094.4 → NP_066580.1  solute carrier organic anion transporter family member 1A2 isoform 1

    See identical proteins and their annotated locations for NP_066580.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. The translation of this protein may be modulated by multiple upstream ORFs that are present in the 5' UTR.
    Source sequence(s)
    AC022224, BX093727, DA216595, U21943
    Consensus CDS
    CCDS8686.1
    UniProtKB/Swiss-Prot
    P46721, Q9UGP7
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  37. NM_134431.5 → NP_602307.1  solute carrier organic anion transporter family member 1A2 isoform 1

    See identical proteins and their annotated locations for NP_602307.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. The translation of this protein may be modulated by multiple upstream ORFs that are present in the 5' UTR.
    Source sequence(s)
    AC006559, AC022224
    Consensus CDS
    CCDS8686.1
    UniProtKB/Swiss-Prot
    P46721, Q9UGP7
    UniProtKB/TrEMBL
    B7ZAD4
    Related
    ENSP00000305974.6, ENST00000307378.10
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

RNA

  1. NR_170340.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022224

  2. NR_170341.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022224

  3. NR_170343.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Related
    ENST00000480394.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    21264600..21419634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520819.2 → XP_011519121.1  solute carrier organic anion transporter family member 1A2 isoform X1

    See identical proteins and their annotated locations for XP_011519121.1

    UniProtKB/Swiss-Prot
    P46721, Q9UGP7
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  2. XM_024449138.2 → XP_024304906.1  solute carrier organic anion transporter family member 1A2 isoform X1

    UniProtKB/Swiss-Prot
    P46721, Q9UGP7
    UniProtKB/TrEMBL
    B7ZAD4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    21143252..21298332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373011.1 → XP_054228986.1  solute carrier organic anion transporter family member 1A2 isoform X1

    UniProtKB/Swiss-Prot
    P46721, Q9UGP7

  2. XM_054373010.1 → XP_054228985.1  solute carrier organic anion transporter family member 1A2 isoform X1

    UniProtKB/Swiss-Prot
    P46721, Q9UGP7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005075.2: Suppressed sequence

    Description
    NM_005075.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46721.1 GenPept UniProtKB/Swiss-Prot:P46721

Gene LinkOut

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