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VDAC2 voltage dependent anion channel 2 [ Homo sapiens (human) ]

Gene ID: 7417, updated on 14-Nov-2024

Summary

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Official Symbol
VDAC2provided by HGNC
Official Full Name
voltage dependent anion channel 2provided by HGNC
Primary source
HGNC:HGNC:12672
See related
Ensembl:ENSG00000165637 MIM:193245; AllianceGenome:HGNC:12672
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POR
Summary
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in heart (RPKM 81.3), esophagus (RPKM 66.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See VDAC2 in Genome Data Viewer
Location:
10q22.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (75210170..75231448)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (76083655..76104942)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76969928..76991206)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 8 Neighboring gene uncharacterized LOC124902460 Neighboring gene ribosomal protein S26 pseudogene 42 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76898750-76898917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76901445-76901944 Neighboring gene MPRA-validated peak1024 silencer Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76966815-76967564 Neighboring gene Sharpr-MPRA regulatory region 10124 Neighboring gene Sharpr-MPRA regulatory region 7934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76982209-76982964 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76983719-76984474 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76985985-76986738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3608 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2513 Neighboring gene Sharpr-MPRA regulatory region 13796 Neighboring gene catechol-O-methyltransferase domain containing 1 Neighboring gene VISTA enhancer hs1437 Neighboring gene ribosomal protein L39 pseudogene 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. N-helix and Cysteines Inter-regulate Human Mitochondrial VDAC-2 Function and Biochemistry. Maurya SR, et al. J Biol Chem, 2015 Dec 18. PMID 26487717, Free PMC Article
  2. Solution NMR spectroscopic characterization of human VDAC-2 in detergent micelles and lipid bilayer nanodiscs. Yu TY, et al. Biochim Biophys Acta, 2012 Jun. PMID 22119777, Free PMC Article
  3. Critical role for voltage-dependent anion channel 2 in infectious bursal disease virus-induced apoptosis in host cells via interaction with VP5. Li Z, et al. J Virol, 2012 Feb. PMID 22114330, Free PMC Article
  4. The use of anti-VDAC2 antibody for the combined assessment of human sperm acrosome integrity and ionophore A23187-induced acrosome reaction. Liu B, et al. PLoS One, 2011 Feb 9. PMID 21347391, Free PMC Article
  5. Voltage-dependent anion channel 2 modulates resting Ca²+ sparks, but not action potential-induced Ca²+ signaling in cardiac myocytes. Subedi KP, et al. Cell Calcium, 2011 Feb. PMID 21241999

See all (254) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM8 promotes ovarian cancer proliferation and migration by targeting VDAC2 for ubiquitination and degradation.
    Title: TRIM8 promotes ovarian cancer proliferation and migration by targeting VDAC2 for ubiquitination and degradation.
  2. STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.
    Title: STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.
  3. Protein mass spectrometry reveals lycorine exerting anti-multiple-myeloma effect by acting on VDAC2 and causing mitochondrial abnormalities.
    Title: Protein mass spectrometry reveals lycorine exerting anti-multiple-myeloma effect by acting on VDAC2 and causing mitochondrial abnormalities.
  4. Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites.
    Title: Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites.
  5. BioID-based proteomic analysis of the Bid interactome identifies novel proteins involved in cell-cycle-dependent apoptotic priming.
    Title: BioID-based proteomic analysis of the Bid interactome identifies novel proteins involved in cell-cycle-dependent apoptotic priming.
  6. Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer.
    Title: Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer.
  7. Bisindolylpyrrole triggers transient mitochondrial permeability transitions to cause apoptosis in a VDAC1/2 and cyclophilin D-dependent manner via the ANT-associated pore.
    Title: Bisindolylpyrrole triggers transient mitochondrial permeability transitions to cause apoptosis in a VDAC1/2 and cyclophilin D-dependent manner via the ANT-associated pore.
  8. Structure-based modeling of turnover of Bcl-2 family proteins bound to voltage-dependent anion channel 2 (VDAC2): Implications for the mechanisms of proapoptotic activation of Bak and Bax in vivo.
    Title: Structure-based modeling of turnover of Bcl-2 family proteins bound to voltage-dependent anion channel 2 (VDAC2): Implications for the mechanisms of proapoptotic activation of Bak and Bax in vivo.
  9. A High Resolution Mass Spectrometry Study Reveals the Potential of Disulfide Formation in Human Mitochondrial Voltage-Dependent Anion Selective Channel Isoforms (hVDACs).
    Title: A High Resolution Mass Spectrometry Study Reveals the Potential of Disulfide Formation in Human Mitochondrial Voltage-Dependent Anion Selective Channel Isoforms (hVDACs).
  10. Expression of voltage-dependent anion channels in endometrial cancer and its potential prognostic significance.
    Title: Expression of voltage-dependent anion channels in endometrial cancer and its potential prognostic significance.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with voltage-dependent anion channel 2 (VDAC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with voltage-dependent anion channel 2 (VDAC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of voltage-dependent anion channel 2 (VDAC2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
vpr The G5 domain of gelsolin inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ceramide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cholesterol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxysterol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables porin activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated monoatomic anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated monoatomic anion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial outer membrane permeabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic anion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in plasma membrane phospholipid scrambling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nucleus HDA PubMed 
part_of pore complex IEA
Inferred from Electronic Annotation
more info
  
located_in sperm midpiece ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
voltage-dependent anion-selective channel protein 2
Names
epididymis secretory sperm binding protein
outer mitochondrial membrane protein porin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184783.3 → NP_001171712.1  voltage-dependent anion-selective channel protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL390034, AL392111
    Consensus CDS
    CCDS53544.1
    UniProtKB/TrEMBL
    A0A0A0MR02
    Related
    ENSP00000361635.1, ENST00000313132.8
    Conserved Domains (1) summary
    cd07306
    Location:30 → 308
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  2. NM_001184823.2 → NP_001171752.1  voltage-dependent anion-selective channel protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001171752.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Both variants 2, 3, and 5 all encode the same isoform (2).
    Source sequence(s)
    AL392111, BC000165, BE545584, BU171142
    Consensus CDS
    CCDS7348.1
    UniProtKB/Swiss-Prot
    P45880, Q5VWK1, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6
    UniProtKB/TrEMBL
    A0A024QZT0, A0A0A0MR02
    Related
    ENSP00000443092.1, ENST00000543351.5
    Conserved Domains (1) summary
    cd07306
    Location:15 → 293
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  3. NM_001324087.2 → NP_001311016.1  voltage-dependent anion-selective channel protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 6 and 7, encodes isoform 3.
    Source sequence(s)
    AL390034, AL392111
    UniProtKB/TrEMBL
    A0A0A0MR02, B4DKM5
    Conserved Domains (1) summary
    cd07306
    Location:12 → 254
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  4. NM_001324088.2 → NP_001311017.1  voltage-dependent anion-selective channel protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 2 and 3, encodes isoform 2.
    Source sequence(s)
    AL390034, AL392111
    Consensus CDS
    CCDS7348.1
    UniProtKB/Swiss-Prot
    P45880, Q5VWK1, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6
    UniProtKB/TrEMBL
    A0A024QZT0, A0A0A0MR02
    Conserved Domains (1) summary
    cd07306
    Location:15 → 293
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  5. NM_001324089.2 → NP_001311018.1  voltage-dependent anion-selective channel protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 7, encodes isoform 3.
    Source sequence(s)
    AL390034, AL392111
    UniProtKB/TrEMBL
    A0A0A0MR02, B4DKM5
    Conserved Domains (1) summary
    cd07306
    Location:12 → 254
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  6. NM_001324090.2 → NP_001311019.1  voltage-dependent anion-selective channel protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 4 and 6, encodes isoform 3.
    Source sequence(s)
    AL390034, AL392111
    UniProtKB/TrEMBL
    A0A0A0MR02, B4DKM5
    Conserved Domains (1) summary
    cd07306
    Location:12 → 254
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  7. NM_001391963.1 → NP_001378892.1  voltage-dependent anion-selective channel protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL390034, AL392111
    Consensus CDS
    CCDS7348.1
    UniProtKB/Swiss-Prot
    P45880, Q5VWK1, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6
    UniProtKB/TrEMBL
    A0A024QZT0, A0A0A0MR02
    Related
    ENSP00000361686.3, ENST00000332211.11
    Conserved Domains (1) summary
    cd07306
    Location:15 → 293
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  8. NM_003375.5 → NP_003366.2  voltage-dependent anion-selective channel protein 2 isoform 2

    See identical proteins and their annotated locations for NP_003366.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2, 3, and 5 all encode the same isoform (2).
    Source sequence(s)
    AL390034, AL392111
    Consensus CDS
    CCDS7348.1
    UniProtKB/Swiss-Prot
    P45880, Q5VWK1, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6
    UniProtKB/TrEMBL
    A0A024QZT0, A0A0A0MR02
    Conserved Domains (1) summary
    cd07306
    Location:15 → 293
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    75210170..75231448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    76083655..76104942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45880.2 GenPept UniProtKB/Swiss-Prot:P45880

Gene LinkOut

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