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TCEAL4 transcription elongation factor A like 4 [ Homo sapiens (human) ]

Gene ID: 79921, updated on 10-Dec-2024

Summary

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Official Symbol
TCEAL4provided by HGNC
Official Full Name
transcription elongation factor A like 4provided by HGNC
Primary source
HGNC:HGNC:26121
See related
Ensembl:ENSG00000133142 AllianceGenome:HGNC:26121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WEX7; NPD017
Summary
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. This family is comprised of nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternatively splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 13. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in ovary (RPKM 91.3), endometrium (RPKM 75.4) and 23 other tissues See more
Orthologs
all
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Genomic context

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See TCEAL4 in Genome Data Viewer
Location:
Xq22.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103576231..103587729)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102023219..102034716)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102831159..102842657)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LL0XNC01-250H12.3 Neighboring gene RAB40A, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29820 Neighboring gene long intergenic non-protein coding RNA 2589 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:102809676-102810875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102840363-102841076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29821 Neighboring gene Sharpr-MPRA regulatory region 5968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29823 Neighboring gene transcription elongation factor A like 3 Neighboring gene transcription elongation factor A like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Down-regulation of transcription elogation factor A (SII) like 4 (TCEAL4) in anaplastic thyroid cancer. Akaishi J, et al. BMC Cancer, 2006 Nov 1. PMID 17076909, Free PMC Article
  2. [Cloning of human B lymphocyte activation-related novel gene]. Lu XW, et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2001 Feb. PMID 12905813
  3. Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets. Ohira M, et al. Oncogene, 2003 Aug 21. PMID 12934113
  4. Identification and Characterization of USP7 Targets in Cancer Cells. Georges A, et al. Sci Rep, 2018 Oct 26. PMID 30367141, Free PMC Article
  5. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Winter EE, et al. BMC Evol Biol, 2005 Oct 12. PMID 16221301, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21174, DKFZp686M0279

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription elongation factor A protein-like 4
Names
TCEA-like protein 4
epididymis secretory sperm binding protein
transcription elongation factor A (SII)-like 4
transcription elongation factor S-II protein-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016315.2 RefSeqGene

    Range
    14285..16499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001006935.3 → NP_001006936.1  transcription elongation factor A protein-like 4 isoform 1

    See identical proteins and their annotated locations for NP_001006936.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF271783
    Consensus CDS
    CCDS14510.2
    UniProtKB/Swiss-Prot
    Q8WY12, Q96EI5, Q9H2H1, Q9H775
    UniProtKB/TrEMBL
    A0A384NKK0, A2RQR6
    Related
    ENSP00000421156.1, ENST00000472484.6
    Conserved Domains (2) summary
    pfam04538
    Location:88 → 190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7 → 154
    Na_Ca_ex; Sodium/calcium exchanger protein

  2. NM_001006937.3 → NP_001006938.1  transcription elongation factor A protein-like 4 isoform 1

    See identical proteins and their annotated locations for NP_001006938.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF314542, AI879651, BP375855
    Consensus CDS
    CCDS14510.2
    UniProtKB/Swiss-Prot
    Q8WY12, Q96EI5, Q9H2H1, Q9H775
    UniProtKB/TrEMBL
    A0A384NKK0, A2RQR6
    Related
    ENSP00000427494.1, ENST00000494801.5
    Conserved Domains (2) summary
    pfam04538
    Location:88 → 190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7 → 154
    Na_Ca_ex; Sodium/calcium exchanger protein

  3. NM_001300901.2 → NP_001287830.1  transcription elongation factor A protein-like 4 isoform 2

    See identical proteins and their annotated locations for NP_001287830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains multiple alternate exons in the 5' region, uses an alternate internal splice site, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a longer N-terminus than isoform 1.
    Source sequence(s)
    AF271783, AF314542, BX104938
    Consensus CDS
    CCDS76004.1
    UniProtKB/Swiss-Prot
    Q96EI5
    Related
    ENSP00000361712.4, ENST00000372629.4
    Conserved Domains (1) summary
    pfam04538
    Location:231 → 333
    BEX; Brain expressed X-linked like family

  4. NM_001305840.2 → NP_001292769.1  transcription elongation factor A protein-like 4 isoform 1

    See identical proteins and their annotated locations for NP_001292769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site and contains an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF314542, AI879651, AL833640, AU253367
    Consensus CDS
    CCDS14510.2
    UniProtKB/Swiss-Prot
    Q8WY12, Q96EI5, Q9H2H1, Q9H775
    UniProtKB/TrEMBL
    A0A384NKK0, A2RQR6
    Related
    ENSP00000424314.1, ENST00000472745.1
    Conserved Domains (2) summary
    pfam04538
    Location:88 → 190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7 → 154
    Na_Ca_ex; Sodium/calcium exchanger protein

  5. NM_001305841.2 → NP_001292770.1  transcription elongation factor A protein-like 4 isoform 1

    See identical proteins and their annotated locations for NP_001292770.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses two alternate splice sites and lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF314542, AI879651, BI084326
    Consensus CDS
    CCDS14510.2
    UniProtKB/Swiss-Prot
    Q8WY12, Q96EI5, Q9H2H1, Q9H775
    UniProtKB/TrEMBL
    A0A384NKK0, A2RQR6
    Related
    ENSP00000415564.2, ENST00000415568.2
    Conserved Domains (2) summary
    pfam04538
    Location:88 → 190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7 → 154
    Na_Ca_ex; Sodium/calcium exchanger protein

  6. NM_001305842.2 → NP_001292771.1  transcription elongation factor A protein-like 4 isoform 1

    See identical proteins and their annotated locations for NP_001292771.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF314542, AI879651, AL833640, BF359447
    Consensus CDS
    CCDS14510.2
    UniProtKB/Swiss-Prot
    Q8WY12, Q96EI5, Q9H2H1, Q9H775
    UniProtKB/TrEMBL
    A0A384NKK0, A2RQR6
    Conserved Domains (2) summary
    pfam04538
    Location:88 → 190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7 → 154
    Na_Ca_ex; Sodium/calcium exchanger protein

  7. NM_024863.6 → NP_079139.4  transcription elongation factor A protein-like 4 isoform 1

    See identical proteins and their annotated locations for NP_079139.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AI879651, AL833640
    Consensus CDS
    CCDS14510.2
    UniProtKB/Swiss-Prot
    Q8WY12, Q96EI5, Q9H2H1, Q9H775
    UniProtKB/TrEMBL
    A0A384NKK0, A2RQR6
    Related
    ENSP00000421857.1, ENST00000468024.5
    Conserved Domains (2) summary
    pfam04538
    Location:88 → 190
    BEX; Brain expressed X-linked like family
    cl27511
    Location:7 → 154
    Na_Ca_ex; Sodium/calcium exchanger protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    103576231..103587729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029856.2 → XP_016885345.1  transcription elongation factor A protein-like 4 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    102023219..102034716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327906.1 → XP_054183881.1  transcription elongation factor A protein-like 4 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006936.1: Suppressed sequence

    Description
    NM_001006936.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support the use of a non-consensus splice site in the 5' UTR.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96EI5.2 GenPept UniProtKB/Swiss-Prot:Q96EI5

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