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CD83 CD83 molecule [ Homo sapiens (human) ]

Gene ID: 9308, updated on 10-Dec-2024

Summary

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Official Symbol
CD83provided by HGNC
Official Full Name
CD83 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1703
See related
Ensembl:ENSG00000112149 MIM:604534; AllianceGenome:HGNC:1703
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BL11; HB15
Summary
The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Broad expression in bone marrow (RPKM 72.2), lymph node (RPKM 25.8) and 14 other tissues See more
Orthologs
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Genomic context

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See CD83 in Genome Data Viewer
Location:
6p23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (14117256..14136918)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (13989721..14009378)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (14117487..14137149)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374939 Neighboring gene CRISPRi-validated cis-regulatory element chr6.709 Neighboring gene uncharacterized LOC124901265 Neighboring gene CRISPRi-FlowFISH-validated CD83 regulatory elements GRCh37_chr6:14117366-14118274 to GRCh37_chr6:14117614-14118430 Neighboring gene CRISPRi-FlowFISH-validated CD83 regulatory elements GRCh37_chr6:14118435-14118935 to GRCh37_chr6:14118800-14119300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24047 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:14128774-14129372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24048 Neighboring gene RNA, U7 small nuclear 133 pseudogene Neighboring gene MPRA-validated peak5669 silencer Neighboring gene uncharacterized LOC105374940

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Herpes simplex virus type 1 induces CD83 degradation in mature dendritic cells with immediate-early kinetics via the cellular proteasome. Kummer M, et al. J Virol, 2007 Jun. PMID 17428858, Free PMC Article
  2. Soluble CD83 inhibits human monocyte differentiation into dendritic cells in vitro. Lin H, et al. Cell Immunol, 2014 Nov-Dec. PMID 25243645
  3. Dendritic cell membrane CD83 enhances immune responses by boosting intracellular calcium release in T lymphocytes. Pinho MP, et al. J Leukoc Biol, 2014 May. PMID 24436459
  4. Genetic variation in CD83 and risks of cervical and vulvar cancers: a population-based case-control study. Bodelon C, et al. Gynecol Oncol, 2012 Mar. PMID 22134374, Free PMC Article
  5. CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2. Chen L, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 22065790, Free PMC Article

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism.
    Title: Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism.
  2. Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality.
    Title: Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality.
  3. CD83 Regulates the Immune Responses in Inflammatory Disorders.
    Title: CD83 Regulates the Immune Responses in Inflammatory Disorders.
  4. The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis.
    Title: The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis.
  5. Monocyte Maturation Mediators Upregulate CD83, ICAM-1 and MHC Class 1 Expression on Ewing's Sarcoma, Enhancing T Cell Cytotoxicity.
    Title: Monocyte Maturation Mediators Upregulate CD83, ICAM-1 and MHC Class 1 Expression on Ewing's Sarcoma, Enhancing T Cell Cytotoxicity.
  6. Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses.
    Title: Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses.
  7. Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses.
    Title: Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses.
  8. Difference in Presence and Number of CD83(+) Dendritic Cells in Patients with Ulcerative Colitis and Crohn's Disease.
    Title: Difference in Presence and Number of CD83(+) Dendritic Cells in Patients with Ulcerative Colitis and Crohn's Disease.
  9. Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells.
    Title: Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells.
  10. MHC II ubiquitination by E3 ubiquitin-protein ligase MARCH8 (MARCH8) and CD83 antigen (CD83) plays a critical role in T cell thymic selection [Review].
    Title: MARCH ligases in immunity.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD83 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of CD83 (BL11, HB15) in human B cells PubMed
env Inhibition of CpG-B-induced maturation of plasmacytoid dendritic cells by HIV-1 gp120 results in downregulation of CD40, CD83, CCR7, and HLA-DR expression PubMed
env HIV-1 gp120 inhibits TLR9-mediated upregulation of CD83 and the secretion of inflammatory cytokines TNF-alpha and IL-6, and chemokine IP10 in plasmacytoid dendritic cells (pDC) PubMed
env The presence of HIV-1 gp120 inhibits the oral mucosal pathogen Porphyromonas gingivalis-induced CD80, CD83, and CD86 upregulation PubMed
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD83 PubMed
nef HIV-1 Nef induces upregulation of CD80, CD83, and CD86 protein expression in a concentration dependent fashion in monocyte derived dendritic cells PubMed
Pr55(Gag) gag Expression of CD80, CD83, CD86, and HLA-DR molecules are significantly downregulated in mature dendritic cells after transduction with ubiquitinated Gag compared to unubiquitinated Gag constructs PubMed
Tat tat HIV-1 Tat upregulates the expression of MHC and co-stimulatory molecules CD40, CD80, CD83 and CD86 in monocyte-derived dendritic cells, thereby driving T cell-mediated immune responses PubMed
Vpr vpr HIV-1 Vpr inhibits the expression of co-stimulatory molecules including CD80, CD83, and CD86 at the transcriptional level without altering normal cellular transcription during dendritic cell maturation PubMed
vpr HIV-1 Vpr downregulates the expression of several immunologically important molecules including CD40, CD80, CD83, and CD86 co-stimulatory molecules on monocyte-derived macrophage (MDM) and monocyte-derived dendritic cells (MDDC) PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD83 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in humoral immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of interleukin-4 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
  
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
CD83 antigen
Names
B-cell activation protein
CD83 antigen (activated B lymphocytes, immunoglobulin superfamily)
cell surface protein HB15
cell-surface glycoprotein
hCD83

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030372.1 RefSeqGene

    Range
    5517..24651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040280.3 → NP_001035370.1  CD83 antigen isoform b precursor

    See identical proteins and their annotated locations for NP_001035370.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AK223315, AL133259, BC030830, DB178710
    UniProtKB/Swiss-Prot
    Q01151
    Conserved Domains (2) summary
    smart00410
    Location:21 → 126
    IG_like; Immunoglobulin like
    cl11960
    Location:21 → 127
    Ig; Immunoglobulin domain

  2. NM_001251901.1 → NP_001238830.1  CD83 antigen isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL133259, BC030830, DA532022
    Consensus CDS
    CCDS75403.1
    UniProtKB/TrEMBL
    A0A087WX61
    Related
    ENSP00000480760.1, ENST00000612003.5
    Conserved Domains (1) summary
    cl11960
    Location:12 → 60
    Ig; Immunoglobulin domain

  3. NM_004233.4 → NP_004224.1  CD83 antigen isoform a precursor

    See identical proteins and their annotated locations for NP_004224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL133259, BC030830, DB178710
    Consensus CDS
    CCDS4532.1
    UniProtKB/Swiss-Prot
    Q01151, Q5THX9
    Related
    ENSP00000368450.3, ENST00000379153.4
    Conserved Domains (1) summary
    cl11960
    Location:21 → 127
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    14117256..14136918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    13989721..14009378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01151.1 GenPept UniProtKB/Swiss-Prot:Q01151

Gene LinkOut

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