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    VDAC1 voltage dependent anion channel 1 [ Homo sapiens (human) ]

    Gene ID: 7416, updated on 3-Dec-2024

    Summary

    Official Symbol
    VDAC1provided by HGNC
    Official Full Name
    voltage dependent anion channel 1provided by HGNC
    Primary source
    HGNC:HGNC:12669
    See related
    Ensembl:ENSG00000213585 MIM:604492; AllianceGenome:HGNC:12669
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PORIN; VDAC-1
    Summary
    This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in heart (RPKM 107.1), duodenum (RPKM 94.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See VDAC1 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (133971871..134114540, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (134495517..134638169, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133307562..133450231, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23112 Neighboring gene uncharacterized LOC105379183 Neighboring gene chromosome 5 open reading frame 15 Neighboring gene MPRA-validated peak5471 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23120 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133382518-133383158 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133383159-133383798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133385203-133385778 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:133387505-133388080 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133394172-133394770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133394771-133395367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23121 Neighboring gene short transmembrane mitochondrial protein 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133422388-133422888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133422889-133423389 Neighboring gene Sharpr-MPRA regulatory region 10905 Neighboring gene Sharpr-MPRA regulatory region 12956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133437181-133438148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133438510-133439380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133441120-133441988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133442973-133443520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23127 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133457701-133458202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133464814-133465636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133465637-133466458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23130 Neighboring gene transcription factor 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133475053-133476030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133513545-133514059 Neighboring gene S-phase kinase associated protein 1 Neighboring gene protein phosphatase 2 catalytic subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23139 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133561503-133562022 Neighboring gene microRNA 3661

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with voltage-dependent anion channel 1 (VDAC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with voltage-dependent anion channel 1 (VDAC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Nef nef HIV-1 Nef downregulates the expression of voltage-dependent anion channel 1 (VDAC1) protein in Nef-transfected SupT1 cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of voltage-dependent anion channel 1 (VDAC1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    vpr The G5 domain of gelsolin inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC PubMed
    vpr HIV-1 Vpr interacts with a molecular complex of voltage-dependent anion channel (VDAC) and adenine nucleotide translocator (ANT) by directly binding to ANT resulting in the induction of mitochondrial membrane permeabilization PubMed
    retropepsin gag-pol HIV-1 PR cleaves VDAC in a dose-dependent manner in HEK293 cells PubMed
    gag-pol HIV-1 PR interacts with mitochondrial proteins VDAC, cytochrome c, TOM22, and Bax in HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC111064

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ceramide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cholesterol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables oxysterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylcholine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated monoatomic anion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables voltage-gated monoatomic anion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables voltage-gated monoatomic anion channel activity TAS
    Traceable Author Statement
    more info
     
    enables voltage-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium import into the mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epithelial cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic anion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of calcium import into the mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron-neuron synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type 2 mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyruvate metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of autophagy of mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    non-selective voltage-gated ion channel VDAC1
    Names
    outer mitochondrial membrane protein porin 1
    plasmalemmal porin
    porin 31HL
    porin 31HM
    sperm binding protein 1a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027817.3 RefSeqGene

      Range
      114565..147669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001401008.1NP_001387937.1  non-selective voltage-gated ion channel VDAC1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      Consensus CDS
      CCDS4168.1
      UniProtKB/Swiss-Prot
      B3KVK4, D3DQ93, P21796, Q5FVE7, Q9UIQ5, Q9UPL0
      UniProtKB/TrEMBL
      A0A1L1UHR1, B3KTS5
    2. NM_001401009.1NP_001387938.1  non-selective voltage-gated ion channel VDAC1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      Consensus CDS
      CCDS4168.1
      UniProtKB/Swiss-Prot
      B3KVK4, D3DQ93, P21796, Q5FVE7, Q9UIQ5, Q9UPL0
      UniProtKB/TrEMBL
      A0A1L1UHR1, B3KTS5
    3. NM_001401010.1NP_001387939.1  non-selective voltage-gated ion channel VDAC1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      Consensus CDS
      CCDS4168.1
      UniProtKB/Swiss-Prot
      B3KVK4, D3DQ93, P21796, Q5FVE7, Q9UIQ5, Q9UPL0
      UniProtKB/TrEMBL
      A0A1L1UHR1, B3KTS5
    4. NM_001401011.1NP_001387940.1  non-selective voltage-gated ion channel VDAC1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      Consensus CDS
      CCDS4168.1
      UniProtKB/Swiss-Prot
      B3KVK4, D3DQ93, P21796, Q5FVE7, Q9UIQ5, Q9UPL0
      UniProtKB/TrEMBL
      A0A1L1UHR1, B3KTS5
    5. NM_001401016.1NP_001387945.1  non-selective voltage-gated ion channel VDAC1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      Consensus CDS
      CCDS4168.1
      UniProtKB/Swiss-Prot
      B3KVK4, D3DQ93, P21796, Q5FVE7, Q9UIQ5, Q9UPL0
      UniProtKB/TrEMBL
      A0A1L1UHR1, B3KTS5
    6. NM_001401017.1NP_001387946.1  non-selective voltage-gated ion channel VDAC1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      Consensus CDS
      CCDS4168.1
      UniProtKB/Swiss-Prot
      B3KVK4, D3DQ93, P21796, Q5FVE7, Q9UIQ5, Q9UPL0
      UniProtKB/TrEMBL
      A0A1L1UHR1, B3KTS5
    7. NM_001401018.1NP_001387947.1  non-selective voltage-gated ion channel VDAC1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      Consensus CDS
      CCDS4168.1
      UniProtKB/Swiss-Prot
      B3KVK4, D3DQ93, P21796, Q5FVE7, Q9UIQ5, Q9UPL0
      UniProtKB/TrEMBL
      A0A1L1UHR1, B3KTS5
    8. NM_001401020.1NP_001387949.1  non-selective voltage-gated ion channel VDAC1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      Consensus CDS
      CCDS4168.1
      UniProtKB/Swiss-Prot
      B3KVK4, D3DQ93, P21796, Q5FVE7, Q9UIQ5, Q9UPL0
      UniProtKB/TrEMBL
      A0A1L1UHR1, B3KTS5
      Related
      ENSP00000378484.3, ENST00000395044.7
    9. NM_001401021.1NP_001387950.1  non-selective voltage-gated ion channel VDAC1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      Consensus CDS
      CCDS4168.1
      UniProtKB/Swiss-Prot
      B3KVK4, D3DQ93, P21796, Q5FVE7, Q9UIQ5, Q9UPL0
      UniProtKB/TrEMBL
      A0A1L1UHR1, B3KTS5
      Related
      ENSP00000378487.2, ENST00000395047.6
    10. NM_001401022.1NP_001387951.1  non-selective voltage-gated ion channel VDAC1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      Consensus CDS
      CCDS4168.1
      UniProtKB/Swiss-Prot
      B3KVK4, D3DQ93, P21796, Q5FVE7, Q9UIQ5, Q9UPL0
      UniProtKB/TrEMBL
      A0A1L1UHR1, B3KTS5
    11. NM_001401023.1NP_001387952.1  non-selective voltage-gated ion channel VDAC1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      Consensus CDS
      CCDS4168.1
      UniProtKB/Swiss-Prot
      B3KVK4, D3DQ93, P21796, Q5FVE7, Q9UIQ5, Q9UPL0
      UniProtKB/TrEMBL
      A0A1L1UHR1, B3KTS5
    12. NM_001401024.1NP_001387953.1  non-selective voltage-gated ion channel VDAC1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
    13. NM_001401025.1NP_001387954.1  non-selective voltage-gated ion channel VDAC1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      UniProtKB/TrEMBL
      B3KTS5
    14. NM_001401026.1NP_001387955.1  non-selective voltage-gated ion channel VDAC1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      UniProtKB/TrEMBL
      B3KTS5
    15. NM_001401027.1NP_001387956.1  non-selective voltage-gated ion channel VDAC1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC008608
    16. NM_001401028.1NP_001387957.1  non-selective voltage-gated ion channel VDAC1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
      UniProtKB/TrEMBL
      B3KTS5
    17. NM_001401029.1NP_001387958.1  non-selective voltage-gated ion channel VDAC1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
    18. NM_001401031.1NP_001387960.1  non-selective voltage-gated ion channel VDAC1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
    19. NM_001401032.1NP_001387961.1  non-selective voltage-gated ion channel VDAC1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC008608, AC025177
    20. NM_003374.3NP_003365.1  non-selective voltage-gated ion channel VDAC1 isoform 1

      See identical proteins and their annotated locations for NP_003365.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AC008608, AC025177, AK095989, BC008482, L06132
      Consensus CDS
      CCDS4168.1
      UniProtKB/Swiss-Prot
      B3KVK4, D3DQ93, P21796, Q5FVE7, Q9UIQ5, Q9UPL0
      UniProtKB/TrEMBL
      A0A1L1UHR1, B3KTS5
      Related
      ENSP00000265333.3, ENST00000265333.8
      Conserved Domains (1) summary
      cd07306
      Location:4282
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      133971871..134114540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      134495517..134638169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)