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    PPP2R5C protein phosphatase 2 regulatory subunit B'gamma [ Homo sapiens (human) ]

    Gene ID: 5527, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PPP2R5Cprovided by HGNC
    Official Full Name
    protein phosphatase 2 regulatory subunit B'gammaprovided by HGNC
    Primary source
    HGNC:HGNC:9311
    See related
    Ensembl:ENSG00000078304 MIM:601645; AllianceGenome:HGNC:9311
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B56G; PR61G; B56gamma
    Summary
    The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 21.8), testis (RPKM 19.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPP2R5C in Genome Data Viewer
    Location:
    14q32.31
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (101760573..101927992)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (95996275..96163606)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102226910..102394329)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2320 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102155672-102155835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102174026-102174796 Neighboring gene ribosomal protein L26 pseudogene 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102184781-102184986 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:102188573-102189513 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:102197209-102198408 Neighboring gene long intergenic non-protein coding RNA 239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6099 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6100 Neighboring gene uncharacterized LOC107984658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9045 Neighboring gene uncharacterized LOC124903388 Neighboring gene Sharpr-MPRA regulatory region 9024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:102276373-102276955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9048 Neighboring gene RNA, U6 small nuclear 790, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102299052-102299552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9055 Neighboring gene nucleophosmin 1 pseudogene 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9057 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:102383507-102384162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102394426-102394926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102394927-102395427 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:102411293-102411954 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:102411955-102412614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102413937-102414598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9059 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102427622-102427798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9061 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102431258-102431867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102430647-102431257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102436952-102437452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9064 Neighboring gene dynein cytoplasmic 1 heavy chain 1 Neighboring gene NANOG hESC enhancer GRCh37_chr14:102474230-102474777 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:102493659-102494858 Neighboring gene uncharacterized LOC107984661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102515797-102516781 Neighboring gene Sharpr-MPRA regulatory region 9666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102522673-102523378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102523379-102524082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102530418-102531305 Neighboring gene RNA, 7SL, cytoplasmic 472, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells. Guichard C, et al. Carcinogenesis, 2006 Sep. PMID 16524888
    2. Proteomic studies of PP2A-B56gamma1 phosphatase complexes reveal phosphorylation-regulated partners in cardiac local signaling. Zhou XW, et al. J Proteome Res, 2007 Sep. PMID 17663574
    3. HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive function. Nobumori Y, et al. J Biol Chem, 2012 Mar 30. PMID 22315229, Free PMC Article
    4. A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment. Wang X, et al. Elife, 2020 Mar 20. PMID 32195664, Free PMC Article
    5. Expression and distribution of PPP2R5C gene in leukemia. Zheng H, et al. J Hematol Oncol, 2011 May 6. PMID 21548944, Free PMC Article

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening.
      Title: Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening.
    2. A functional interaction between liprin-alpha1 and B56gamma regulatory subunit of protein phosphatase 2A supports tumor cell motility.
      Title: A functional interaction between liprin-α1 and B56γ regulatory subunit of protein phosphatase 2A supports tumor cell motility.
    3. [The Relationship between PPP2R5C and Molt-4 Cell Viability, HSP90-GR Signal in Childhood Acute T Lymphocytic Leukemia].
      Title: [The Relationship between PPP2R5C and Molt-4 Cell Viability, HSP90-GR Signal in Childhood Acute T Lymphocytic Leukemia].
    4. A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment.
      Title: A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment.
    5. Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis.
      Title: Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis.
    6. Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56gamma.
      Title: Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ.
    7. Structural basis of host protein hijacking in human T-cell leukemia virus integration.
      Title: Structural basis of host protein hijacking in human T-cell leukemia virus integration.
    8. PPP2R5C deletion or EGFR mutation that could be responsible for IER3/pERK overexpression was found in at least 8 cases (67% or more) of lung adenocarcinoma.
      Title: Activation of ERK/IER3/PP2A-B56γ-positive feedback loop in lung adenocarcinoma by allelic deletion of B56γ gene.
    9. Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth
      Title: Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth.
    10. our data suggest that hepatic PPP2R5C represents an important factor in the functional wiring of energy metabolism and the maintenance of a metabolically healthy state.
      Title: PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide scan for common alleles affecting risk for autism.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
    tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
    tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
    Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
    vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
    vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
    nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC23064

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase regulator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase type 2A complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
    Names
    B' alpha regulatory subunit
    protein phosphatase 2 regulatory subunit B', gamma
    renal carcinoma antigen NY-REN-29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047069.1 RefSeqGene

      Range
      6137..172405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161725.2 → NP_001155197.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is longer than isoform a.
      Source sequence(s)
      AA487513, AI282996, AI692258, AK131391, AK302470, AL137779
      Consensus CDS
      CCDS53912.1
      UniProtKB/TrEMBL
      Q7L7W2
      Related
      ENSP00000412324.2, ENST00000422945.6
      Conserved Domains (2) summary
      PLN00122
      Location:373 → 473
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:65 → 468
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. NM_001161726.2 → NP_001155198.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform f

      See identical proteins and their annotated locations for NP_001155198.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (f) has a distinct N-terminus and is longer than isoform a.
      Source sequence(s)
      AA487513, AI282996, AI692258, AK131391, AL137779
      Consensus CDS
      CCDS53911.1
      UniProtKB/TrEMBL
      Q96L52
      Related
      ENSP00000329009.5, ENST00000328724.9
      Conserved Domains (1) summary
      pfam01603
      Location:89 → 492
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    3. NM_001352912.1 → NP_001339841.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b

      Status: REVIEWED

      Source sequence(s)
      AL118558, AL137779
      Consensus CDS
      CCDS9965.1
      UniProtKB/TrEMBL
      Q96L52
      Conserved Domains (1) summary
      pfam01603
      Location:32 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    4. NM_001352913.2 → NP_001339842.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform g

      Status: REVIEWED

      Source sequence(s)
      AL118558, AL137779
      Consensus CDS
      CCDS91934.1
      UniProtKB/TrEMBL
      A0A8Q3WKR3, Q7L7W2
      Related
      ENSP00000511581.1, ENST00000694906.1
      Conserved Domains (1) summary
      pfam01603
      Location:89 → 492
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    5. NM_001352914.2 → NP_001339843.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform h

      Status: REVIEWED

      Source sequence(s)
      AL118558, AL137779
      UniProtKB/TrEMBL
      Q96L52
      Conserved Domains (1) summary
      pfam01603
      Location:92 → 497
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    6. NM_001352915.2 → NP_001339844.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform j

      Status: REVIEWED

      Source sequence(s)
      AL118558, AL137779
      UniProtKB/TrEMBL
      Q7L7W2
      Conserved Domains (1) summary
      pfam01603
      Location:1 → 362
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    7. NM_001352916.2 → NP_001339845.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform i

      Status: REVIEWED

      Source sequence(s)
      AL118558, AL137779
      UniProtKB/TrEMBL
      Q96L52
      Conserved Domains (1) summary
      pfam01603
      Location:1 → 362
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    8. NM_002719.4 → NP_002710.2  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform a

      See identical proteins and their annotated locations for NP_002710.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (a), also known as B' alpha 1 and gamma 3.
      Source sequence(s)
      AA487513, AI282996, AK131391, DA853338, U37352
      Consensus CDS
      CCDS9964.1
      UniProtKB/Swiss-Prot
      B4DYJ8, B5BUA5, F5GWP3, Q13362, Q14391, Q15060, Q15174, Q6ZN33
      UniProtKB/TrEMBL
      Q7L7W2
      Related
      ENSP00000333905.4, ENST00000334743.9
      Conserved Domains (2) summary
      PLN00122
      Location:342 → 442
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:34 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    9. NM_178586.3 → NP_848701.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b

      See identical proteins and their annotated locations for NP_848701.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), also known as gamma 2.
      Source sequence(s)
      AA487513, AI282996, AK131391, D26445, DA853338
      Consensus CDS
      CCDS9965.1
      UniProtKB/TrEMBL
      Q96L52
      Related
      ENSP00000262239.5, ENST00000350249.7
      Conserved Domains (1) summary
      pfam01603
      Location:32 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    10. NM_178587.3 → NP_848702.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform c

      See identical proteins and their annotated locations for NP_848702.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and the 3' coding region, compared to variant 1. It encodes an isoform (c), also known as gamma 1, that is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AA716736, DA853338, L42375
      Consensus CDS
      CCDS45163.1
      UniProtKB/TrEMBL
      Q96L51
      Related
      ENSP00000408389.3, ENST00000445439.7
      Conserved Domains (1) summary
      pfam01603
      Location:34 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      101760573..101927992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005267819.2 → XP_005267876.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1

      See identical proteins and their annotated locations for XP_005267876.1

      UniProtKB/TrEMBL
      Q7L7W2
      Conserved Domains (2) summary
      PLN00122
      Location:402 → 502
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:94 → 497
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. XM_005267824.2 → XP_005267881.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3

      UniProtKB/TrEMBL
      Q96L52
      Conserved Domains (2) summary
      PLN00122
      Location:402 → 486
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:94 → 481
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    3. XM_005267827.2 → XP_005267884.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

      See identical proteins and their annotated locations for XP_005267884.1

      UniProtKB/TrEMBL
      Q7L7W2
      Conserved Domains (1) summary
      pfam01603
      Location:1 → 362
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    4. XM_047431541.1 → XP_047287497.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

      UniProtKB/TrEMBL
      Q7L7W2

    5. XM_047431540.1 → XP_047287496.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X12

      UniProtKB/TrEMBL
      Q96L52

    6. XM_047431530.1 → XP_047287486.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2

      UniProtKB/TrEMBL
      Q7L7W2

    7. XM_047431533.1 → XP_047287489.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X7

      UniProtKB/TrEMBL
      Q96L52

    8. XM_047431534.1 → XP_047287490.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X8

      UniProtKB/TrEMBL
      Q96L52

    9. XM_047431537.1 → XP_047287493.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

      UniProtKB/TrEMBL
      Q7L7W2

    10. XM_011536920.2 → XP_011535222.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

      See identical proteins and their annotated locations for XP_011535222.1

      UniProtKB/TrEMBL
      Q7L7W2
      Conserved Domains (1) summary
      pfam01603
      Location:1 → 362
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    11. XM_017021423.3 → XP_016876912.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X9

      UniProtKB/TrEMBL
      Q96L52

    12. XM_047431539.1 → XP_047287495.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

      UniProtKB/TrEMBL
      Q7L7W2

    13. XM_047431532.1 → XP_047287488.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4

      UniProtKB/TrEMBL
      Q7L7W2

    14. XM_047431536.1 → XP_047287492.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

      UniProtKB/TrEMBL
      Q7L7W2

    15. XM_047431538.1 → XP_047287494.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

      UniProtKB/TrEMBL
      Q7L7W2

    16. XM_005267826.2 → XP_005267883.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X6

      UniProtKB/TrEMBL
      Q7L7W2
      Conserved Domains (2) summary
      PLN00122
      Location:318 → 418
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:10 → 413
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    17. XM_047431531.1 → XP_047287487.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4

      UniProtKB/TrEMBL
      Q7L7W2

    18. XM_011536918.2 → XP_011535220.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5

      See identical proteins and their annotated locations for XP_011535220.1

      UniProtKB/TrEMBL
      Q7L7W2
      Conserved Domains (2) summary
      PLN00122
      Location:326 → 426
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:18 → 421
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    19. XM_047431535.1 → XP_047287491.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X10

      UniProtKB/TrEMBL
      Q96L52

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      95996275..96163606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376317.1 → XP_054232292.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

      UniProtKB/TrEMBL
      Q7L7W2

    2. XM_054376306.1 → XP_054232281.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1

      UniProtKB/TrEMBL
      Q7L7W2

    3. XM_054376308.1 → XP_054232283.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3

      UniProtKB/TrEMBL
      Q96L52

    4. XM_054376316.1 → XP_054232291.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X12

      UniProtKB/TrEMBL
      Q96L52

    5. XM_054376307.1 → XP_054232282.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2

      UniProtKB/TrEMBL
      Q7L7W2

    6. XM_054376311.1 → XP_054232286.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X7

      UniProtKB/TrEMBL
      Q96L52

    7. XM_054376312.1 → XP_054232287.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X8

      UniProtKB/TrEMBL
      Q96L52

    8. XM_054376315.1 → XP_054232290.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X11

      UniProtKB/TrEMBL
      Q7L7W2

    9. XM_054376313.1 → XP_054232288.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X9

      UniProtKB/TrEMBL
      Q96L52

    10. XM_054376310.1 → XP_054232285.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X6

      UniProtKB/TrEMBL
      Q7L7W2

    11. XM_054376309.1 → XP_054232284.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5

      UniProtKB/TrEMBL
      Q7L7W2

    12. XM_054376314.1 → XP_054232289.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X10

      UniProtKB/TrEMBL
      Q96L52

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178588.1: Suppressed sequence

      Description
      NM_178588.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13362.3 GenPept UniProtKB/Swiss-Prot:Q13362

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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