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    TAB3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 257397, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TAB3provided by HGNC
    Official Full Name
    TGF-beta activated kinase 1 (MAP3K7) binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:30681
    See related
    Ensembl:ENSG00000157625 MIM:300480; AllianceGenome:HGNC:30681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NAP1; MAP3K7IP3
    Summary
    The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 6.3), endometrium (RPKM 5.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TAB3 in Genome Data Viewer
    Location:
    Xp21.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (30827442..30889254, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (30425653..30487452, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (30845559..30907371, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:30771431-30772154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:30813295-30813854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20726 Neighboring gene myoneurin pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29510 Neighboring gene GK antisense RNA 1 Neighboring gene TAB3 antisense RNA 1 Neighboring gene glycerol kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29513 Neighboring gene Sharpr-MPRA regulatory region 11226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29516 Neighboring gene Sharpr-MPRA regulatory region 5644 Neighboring gene ferritin heavy chain like 17 Neighboring gene dystrophin Neighboring gene RNA, U6 small nuclear 894, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TAB3 overexpression promotes cell proliferation in non-small cell lung cancer and mediates chemoresistance to CDDP in A549 cells via the NF-κB pathway. Chen J, et al. Tumour Biol, 2016 Mar. PMID 26476534
    2. Identification of a human NF-kappaB-activating protein, TAB3. Jin G, et al. Proc Natl Acad Sci U S A, 2004 Feb 17. PMID 14766965, Free PMC Article
    3. Loss of TAB3 expression by shRNA exhibits suppressive bioactivity and increased chemical sensitivity of ovarian cancer cell lines via the NF-κB pathway. Chen Y, et al. Cell Prolif, 2016 Dec. PMID 27651027, Free PMC Article
    4. Evidence for a Role of TGF-β-Activated Kinase 1 and MAP3K7 Binding Protein 3 in Peanut-Specific T-Cell Responses. Saidova A, et al. Int Arch Allergy Immunol, 2019. PMID 30893695
    5. TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway. Zhao J, et al. Oncol Rep, 2018 Nov. PMID 30226617

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-27a-3p upregulation by p65 facilitates cervical tumorigenesis by increasing TAB3 expression and is involved in the positive feedback loop of NF-kappaB signaling.
      Title: miR‑27a‑3p upregulation by p65 facilitates cervical tumorigenesis by increasing TAB3 expression and is involved in the positive feedback loop of NF‑κB signaling.
    2. ZEB2-AS1 regulates the expression of TAB3 and promotes the development of colon cancer by adsorbing microRNA-188.
      Title: ZEB2-AS1 regulates the expression of TAB3 and promotes the development of colon cancer by adsorbing microRNA-188.
    3. Neddylation promotes protein translocation between the cytoplasm and nucleus.
      Title: Neddylation promotes protein translocation between the cytoplasm and nucleus.
    4. TAB3 upregulates PIM1 expression by directly activating the TAK1-STAT3 complex to promote colorectal cancer growth.
      Title: TAB3 upregulates PIM1 expression by directly activating the TAK1-STAT3 complex to promote colorectal cancer growth.
    5. multiple GPCR agonists utilize non-canonical TAB1-TAB2 and TAB1-TAB3-dependent p38 activation to promote endothelial inflammatory responses.
      Title: G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells.
    6. TAB3 may play a significant role at the level of T-cell activation and may also be a candidate biomarker for peanut allergy.
      Title: Evidence for a Role of TGF-β-Activated Kinase 1 and MAP3K7 Binding Protein 3 in Peanut-Specific T-Cell Responses.
    7. these results demonstrated that TAB3 may be a promising therapeutic target for the treatment of Esophageal squamous cell carcinoma.
      Title: TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway.
    8. The combination of WES, genomic triangulation, and systems biology has uncovered perturbations in TGF-beta activated kinase 1 signaling as a novel pathogenic substrate for polyvalvular syndrome.
      Title: Whole Exome Sequencing, Familial Genomic Triangulation, and Systems Biology Converge to Identify a Novel Nonsense Mutation in TAB2-encoded TGF-beta Activated Kinase 1 in a Child with Polyvalvular Syndrome.
    9. Our study provides insights into the mechanism of TAB3 regulating activity and suggests its important implications in triple negative breast cancer metastasis.
      Title: TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer.
    10. Data show that knockdown of transforming growth factor-activated kinase 1 (TAK1)-binding protein 3 (TAB3) inhibited proliferation of non-small cell lung cancer (NSCLC) cells.
      Title: TAB3 overexpression promotes cell proliferation in non-small cell lung cancer and mediates chemoresistance to CDDP in A549 cells via the NF-κB pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr The ability of HIV-1 Vpr to activate NF-kappaB or activator protein 1-dependent luciferase expression requires TAK1, TRAF6, or TAB3 in cells PubMed
    capsid gag The TAK1 kinase complex (TAK1/TAB2/TAB3) contributes to capsid-specific restriction mediated by TRIM5alpha. TRIM5alpha activates TAK1 autophosphorylation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC45404

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of autophagy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
    Names
    NF-kappa-B-activating protein 1
    NFkB activating protein 1
    TAB-3
    TAK1-binding protein 3
    TGF-beta activated kinase 1 and MAP3K7 binding protein 3
    TGF-beta-activated kinase 1-binding protein 3
    mitogen-activated protein kinase kinase kinase 7 interacting protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012845.2 RefSeqGene

      Range
      5141..66953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001399870.1 → NP_001386799.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC108359, AC117405, KF459043

    2. NM_001399872.1 → NP_001386801.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC108359, AC117405, KF459043
      Consensus CDS
      CCDS94584.1
      Related
      ENSP00000368214.2, ENST00000378932.6

    3. NM_001399873.1 → NP_001386802.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC108359, AC117405, KF459043

    4. NM_152787.5 → NP_690000.3  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 1

      See identical proteins and their annotated locations for NP_690000.3

      Status: REVIEWED

      Source sequence(s)
      AC108359, AC117405, AK096786, BC032526, DA494641
      Consensus CDS
      CCDS14226.1
      UniProtKB/Swiss-Prot
      A6NDD9, Q6VQR0, Q8N5C8
      UniProtKB/TrEMBL
      Q5JPK0
      Related
      ENSP00000288422.4, ENST00000288422.4
      Conserved Domains (4) summary
      smart00547
      Location:687 → 709
      ZnF_RBZ; Zinc finger domain
      PRK10263
      Location:245 → 345
      PRK10263; DNA translocase FtsK; Provisional
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:687 → 706
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RNA

    1. NR_174361.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC108359, AC117405, KF459043

    2. NR_174362.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC108359, AC117405, KF459043

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      30827442..30889254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441986.1 → XP_047297942.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A6NDD9, Q6VQR0, Q8N5C8

    2. XM_017029400.2 → XP_016884889.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      UniProtKB/TrEMBL
      Q5JPK0
      Conserved Domains (3) summary
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      pfam03153
      Location:122 → 291
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam13900
      Location:634 → 681
      GVQW; Putative domain of unknown function

    3. XM_047441987.1 → XP_047297943.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X3

    4. XM_011545488.3 → XP_011543790.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X4

      UniProtKB/TrEMBL
      F6SS63
      Conserved Domains (2) summary
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      pfam03153
      Location:122 → 291
      TFIIA; Transcription factor IIA, alpha/beta subunit

    5. XM_017029402.2 → XP_016884891.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X5

      UniProtKB/TrEMBL
      F6SS63
      Related
      ENSP00000433193.1, ENST00000467136.5

    RNA

    1. XR_950433.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      30425653..30487452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326818.1 → XP_054182793.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A6NDD9, Q6VQR0, Q8N5C8

    2. XM_054326817.1 → XP_054182792.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

    3. XM_054326819.1 → XP_054182794.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X3

    4. XM_054326820.1 → XP_054182795.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X4

    5. XM_054326821.1 → XP_054182796.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X5

    RNA

    1. XR_008485476.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198312.1: Suppressed sequence

      Description
      NM_198312.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N5C8.3 GenPept UniProtKB/Swiss-Prot:Q8N5C8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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