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    G3BP2 G3BP stress granule assembly factor 2 [ Homo sapiens (human) ]

    Gene ID: 9908, updated on 2-Nov-2024

    Summary

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    Official Symbol
    G3BP2provided by HGNC
    Official Full Name
    G3BP stress granule assembly factor 2provided by HGNC
    Primary source
    HGNC:HGNC:30291
    See related
    Ensembl:ENSG00000138757 MIM:620020; AllianceGenome:HGNC:30291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables molecular condensate scaffold activity. Involved in positive regulation of stress granule assembly; protein homooligomerization; and stress granule assembly. Located in cytoplasmic stress granule and cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 45.6), thyroid (RPKM 35.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See G3BP2 in Genome Data Viewer
    Location:
    4q21.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (75642786..75724437, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (78982913..79064565, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76567970..76649621, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12890 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene cytochrome c oxidase subunit 6C pseudogene 9 Neighboring gene cyclin dependent kinase like 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76597475-76598452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76599431-76600408 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76600409-76601385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21621 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:76627962-76628708 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:76630201-76630946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:76641306-76641821 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76648951-76649871 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76649872-76650791 Neighboring gene USO1 vesicle transport factor Neighboring gene uncharacterized LOC105377284 Neighboring gene RNA, U2 small nuclear 16, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Gupta N, et al. Proc Natl Acad Sci U S A, 2017 Jan 31. PMID 28096337, Free PMC Article
    2. Crystal structure of the G3BP2 NTF2-like domain in complex with a canonical FGDF motif peptide. Kristensen O. Biochem Biophys Res Commun, 2015 Nov 6. PMID 26410532
    3. RIOK1 mediates p53 degradation and radioresistance in colorectal cancer through phosphorylation of G3BP2. Chen Y, et al. Oncogene, 2022 Jun. PMID 35589951
    4. Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery. Götte B, et al. PLoS Pathog, 2019 Jun. PMID 31199850, Free PMC Article
    5. Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif. Kennedy D, et al. Biomed Pept Proteins Nucleic Acids, 1996-1997. PMID 9575347

    See all (229) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal miRNA-92a derived from cancer-associated fibroblasts promote invasion and metastasis in breast cancer by regulating G3BP2.
      Title: Exosomal miRNA-92a derived from cancer-associated fibroblasts promote invasion and metastasis in breast cancer by regulating G3BP2.
    2. Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway.
      Title: Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway.
    3. USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC.
      Title: USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC.
    4. EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA.
      Title: EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA.
    5. MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.
      Title: MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.
    6. Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation.
      Title: Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation.
    7. BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma.
      Title: BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma.
    8. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
      Title: G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
    9. A novel signaling pathway consisting of alpha-parvin, G3BP2, and TWIST1 regulates breast cancer progression and metastasis, this suggests that the activation of this signaling pathway is a key factor for driving the progression and poor clinical outcome of human ER-negative breast cancer.
      Title: α-Parvin promotes breast cancer progression and metastasis through interaction with G3BP2 and regulation of TWIST1 signaling.
    10. These data confirm that G3BP is a ribosomal binding protein and reveal that alphaviral nsP3 uses G3BP to concentrate viral replication complexes and to recruit the translation initiation machinery, promoting the efficient translation of viral mRNAs.
      Title: Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with GTPase activating protein (SH3 domain) binding protein 2 (G3BP2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Vpr vpr HIV-1 Vpr upregulates G3BP2 in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular condensate scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular condensate scaffold activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor complex adaptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cytoplasmic sequestering of NF-kappaB NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of stress granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress granule assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating protein-binding protein 2
    Names
    G3BP-2
    GAP SH3 domain-binding protein 2
    GTPase activating protein (SH3 domain) binding protein 2
    Ras-GTPase activating protein SH3 domain-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400004.1 → NP_001386933.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3571.1
      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
      Related
      ENSP00000503239.1, ENST00000678062.1

    2. NM_001400005.1 → NP_001386934.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3571.1
      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
      Related
      ENSP00000504698.1, ENST00000678100.1

    3. NM_001400006.1 → NP_001386935.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3571.1
      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
      Related
      ENSP00000504316.1, ENST00000677620.1

    4. NM_001400007.1 → NP_001386936.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3571.1
      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
      Related
      ENSP00000504371.1, ENST00000678971.1

    5. NM_001400008.1 → NP_001386937.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3571.1
      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
      Related
      ENSP00000504101.1, ENST00000677162.1

    6. NM_001400010.1 → NP_001386939.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3571.1
      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
      Related
      ENSP00000503504.1, ENST00000678123.1

    7. NM_001400011.1 → NP_001386940.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3571.1
      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
      Related
      ENSP00000503669.1, ENST00000676974.1

    8. NM_001400012.1 → NP_001386941.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3571.1
      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
      Related
      ENSP00000503911.1, ENST00000677171.1

    9. NM_001400013.1 → NP_001386942.1  ras GTPase-activating protein-binding protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3572.1
      Related
      ENSP00000504591.1, ENST00000677265.1

    10. NM_001400014.1 → NP_001386943.1  ras GTPase-activating protein-binding protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3572.1
      Related
      ENSP00000504564.1, ENST00000677583.1

    11. NM_001400015.1 → NP_001386944.1  ras GTPase-activating protein-binding protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3572.1
      Related
      ENSP00000504206.1, ENST00000677876.1

    12. NM_001400016.1 → NP_001386945.1  ras GTPase-activating protein-binding protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3572.1
      Related
      ENSP00000503496.1, ENST00000676666.1

    13. NM_001400017.1 → NP_001386946.1  ras GTPase-activating protein-binding protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3572.1
      Related
      ENSP00000504363.1, ENST00000678122.1

    14. NM_001400018.1 → NP_001386947.1  ras GTPase-activating protein-binding protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3572.1
      Related
      ENSP00000503209.1, ENST00000677125.1

    15. NM_001400019.1 → NP_001386948.1  ras GTPase-activating protein-binding protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3572.1
      Related
      ENSP00000504588.1, ENST00000678552.1

    16. NM_001400020.1 → NP_001386949.1  ras GTPase-activating protein-binding protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS3572.1

    17. NM_001400021.1 → NP_001386950.1  ras GTPase-activating protein-binding protein 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS93545.1
      UniProtKB/TrEMBL
      A0A7I2V3P9
      Related
      ENSP00000503586.1, ENST00000677889.1

    18. NM_001400022.1 → NP_001386951.1  ras GTPase-activating protein-binding protein 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Consensus CDS
      CCDS93544.1
      UniProtKB/TrEMBL
      A0A7I2V647
      Related
      ENSP00000504764.1, ENST00000678244.1

    19. NM_012297.5 → NP_036429.2  ras GTPase-activating protein-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_036429.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AB014560, AI913597, BM744299, DA094091
      Consensus CDS
      CCDS3571.1
      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
      UniProtKB/TrEMBL
      A8K6V7
      Related
      ENSP00000379069.3, ENST00000395719.7
      Conserved Domains (2) summary
      cd00780
      Location:7 → 135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326 → 408
      RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

    20. NM_203504.3 → NP_987100.1  ras GTPase-activating protein-binding protein 2 isoform b

      See identical proteins and their annotated locations for NP_987100.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB014560, AI913597, BC011731, BM744299, DA385285
      Consensus CDS
      CCDS3572.1
      UniProtKB/TrEMBL
      A8K6V7
      Related
      ENSP00000350518.3, ENST00000357854.7
      Conserved Domains (2) summary
      cd00780
      Location:7 → 135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:293 → 375
      RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

    21. NM_203505.3 → NP_987101.1  ras GTPase-activating protein-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_987101.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AB014560, AF145284, AI913597, BM744299, DB241424
      Consensus CDS
      CCDS3571.1
      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
      UniProtKB/TrEMBL
      A8K6V7
      Related
      ENSP00000352738.4, ENST00000359707.9
      Conserved Domains (2) summary
      cd00780
      Location:7 → 135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326 → 408
      RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

    RNA

    1. NR_174376.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Related
      ENST00000677727.1

    2. NR_174377.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Related
      ENST00000677952.1

    3. NR_174378.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104828
      Related
      ENST00000677003.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      75642786..75724437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416466.1 → XP_047272422.1  ras GTPase-activating protein-binding protein 2 isoform X2

      Related
      ENSP00000503688.1, ENST00000676470.1

    2. XM_047416465.1 → XP_047272421.1  ras GTPase-activating protein-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
      Related
      ENSP00000503228.1, ENST00000677606.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      78982913..79064565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351346.1 → XP_054207321.1  ras GTPase-activating protein-binding protein 2 isoform X2

    2. XM_054351343.1 → XP_054207318.1  ras GTPase-activating protein-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1

    3. XM_054351345.1 → XP_054207320.1  ras GTPase-activating protein-binding protein 2 isoform X2

    4. XM_054351344.1 → XP_054207319.1  ras GTPase-activating protein-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K6X1, O60606, O75149, Q9UN86, Q9UPA1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UN86.2 GenPept UniProtKB/Swiss-Prot:Q9UN86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous