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    kcnd1 potassium voltage-gated channel, Shal-related subfamily, member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100001681, updated on 2-Nov-2024

    Summary

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    Official Symbol
    kcnd1provided by ZNC
    Official Full Name
    potassium voltage-gated channel, Shal-related subfamily, member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081105-40
    See related
    Ensembl:ENSDARG00000074746 AllianceGenome:ZFIN:ZDB-GENE-081105-40
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-8e10.1
    Summary
    Predicted to enable A-type (transient outward) potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport; potassium ion transport; and protein homooligomerization. Predicted to be located in cell projection and membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in dendritic spine; neuronal cell body; and postsynaptic membrane. Orthologous to human KCND1 (potassium voltage-gated channel subfamily D member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kcnd1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (9850730..9988548)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (9816608..9949958)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene MON1 secretory trafficking family member Ba Neighboring gene GRIP1 associated protein 1 Neighboring gene uncharacterized LOC137496329 Neighboring gene scavenger receptor cysteine-rich type 1 protein M130 Neighboring gene microRNA mir-7133

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables A-type (transient outward) potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    A-type voltage-gated potassium channel KCND1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126470.1 → NP_001119942.1  A-type voltage-gated potassium channel KCND1

      See identical proteins and their annotated locations for NP_001119942.1

      Status: PROVISIONAL

      Source sequence(s)
      CR450789, CT573497
      UniProtKB/TrEMBL
      A0A8M1NJF2, B0UYF4
      Related
      ENSDARP00000145124.1, ENSDART00000188610.1
      Conserved Domains (6) summary
      smart00225
      Location:44 → 132
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:217 → 415
      Ion_trans; Ion transport protein
      pfam02214
      Location:42 → 131
      BTB_2; BTB/POZ domain
      pfam07885
      Location:331 → 411
      Ion_trans_2; Ion channel
      pfam11601
      Location:3 → 28
      Shal-type; Shal-type voltage-gated potassium channels
      pfam11879
      Location:445 → 542
      DUF3399; Domain of unknown function (DUF3399)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      9850730..9988548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017357258.3 → XP_017212747.1  A-type voltage-gated potassium channel KCND1 isoform X1

      UniProtKB/TrEMBL
      A0A8M1NJF2, B0UYF4
      Conserved Domains (6) summary
      smart00225
      Location:44 → 132
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:217 → 415
      Ion_trans; Ion transport protein
      pfam02214
      Location:42 → 131
      BTB_2; BTB/POZ domain
      pfam07885
      Location:331 → 411
      Ion_trans_2; Ion channel
      pfam11601
      Location:3 → 28
      Shal-type; Shal-type voltage-gated potassium channels
      pfam11879
      Location:445 → 542
      DUF3399; Domain of unknown function (DUF3399)

    2. XM_005166707.5 → XP_005166764.1  A-type voltage-gated potassium channel KCND1 isoform X1

      See identical proteins and their annotated locations for XP_005166764.1

      UniProtKB/TrEMBL
      A0A8M1NJF2, B0UYF4
      Related
      ENSDARP00000120299.1, ENSDART00000133985.2
      Conserved Domains (6) summary
      smart00225
      Location:44 → 132
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:217 → 415
      Ion_trans; Ion transport protein
      pfam02214
      Location:42 → 131
      BTB_2; BTB/POZ domain
      pfam07885
      Location:331 → 411
      Ion_trans_2; Ion channel
      pfam11601
      Location:3 → 28
      Shal-type; Shal-type voltage-gated potassium channels
      pfam11879
      Location:445 → 542
      DUF3399; Domain of unknown function (DUF3399)
    Nucleotide Protein
    Heading Accession and Version

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