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    IPO7 importin 7 [ Homo sapiens (human) ]

    Gene ID: 10527, updated on 28-Oct-2024

    Summary

    Official Symbol
    IPO7provided by HGNC
    Official Full Name
    importin 7provided by HGNC
    Primary source
    HGNC:HGNC:9852
    See related
    Ensembl:ENSG00000205339 MIM:605586; AllianceGenome:HGNC:9852
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Imp7; RANBP7
    Summary
    The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 38.5), urinary bladder (RPKM 24.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See IPO7 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (9384652..9448127)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (9469789..9533256)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9406199..9469674)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tRNA-Leu (CAA) 5-1 Neighboring gene transmembrane protein 41B Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:9335331-9335848 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:9335849-9336364 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9339994-9340970 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:9340971-9341947 Neighboring gene proline rich 13 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9372391-9372892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9376493-9376993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9377088-9377646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9377647-9378203 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:9385258-9386457 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9406201-9406716 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:9420900-9421065 Neighboring gene Sharpr-MPRA regulatory region 11606 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9480928-9481563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3126 Neighboring gene ZNF143 antisense RNA 1 Neighboring gene zinc finger protein 143 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3127 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9537259-9537799

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of IPO7 PubMed
    High levels of additive and synergic antiretroviral activity are obtained by using antiretroviral compounds (T1249, 3TC, RAL, or IDV) in PM1 cells stably expressing anti-host shRNAs (IPO7, HSPD1, or ATG16) or anti-HIV shRNAs (Pol, RT, or Nef) PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify importin 7 (IPO7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify importin 7 (IPO7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify importin 7 (IPO7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    nef High levels of additive and synergic antiretroviral activity are obtained by using antiretroviral compounds (T1249, 3TC, RAL, or IDV) in PM1 cells stably expressing anti-host shRNAs (IPO7, HSPD1, or ATG16) or anti-HIV shRNAs (Pol, RT, or Nef) PubMed
    Pol gag-pol High levels of additive and synergic antiretroviral activity are obtained by using antiretroviral compounds (T1249, 3TC, RAL, or IDV) in PM1 cells stably expressing anti-host shRNAs (IPO7, HSPD1, or ATG16) or anti-HIV shRNAs (Pol, RT, or Nef) PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify importin 7 (IPO7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, importin 7 (IPO7), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with IPO7 is decreased by RRE PubMed
    Vpr vpr Importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the active nuclear import of the intracellular HIV-1 reverse transcription complex (RTC) containing HIV-1 RT, IN, NC, MA, and Vpr PubMed
    integrase gag-pol Amino-acid regions ((235)WKGPAKLLWKG and (262)RRKAK) within the C-terminal domain of HIV-1 integrase (IN) are required for efficient IN/Imp7 interaction PubMed
    gag-pol Importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the active nuclear import of the intracellular HIV-1 reverse transcription complex (RTC) containing HIV-1 RT, IN, NC, MA, and Vpr PubMed
    matrix gag Importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the active nuclear import of the intracellular HIV-1 reverse transcription complex (RTC) containing HIV-1 RT, IN, NC, MA, and Vpr PubMed
    nucleocapsid gag Importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the active nuclear import of the intracellular HIV-1 reverse transcription complex (RTC) containing HIV-1 RT, IN, NC, MA, and Vpr PubMed
    reverse transcriptase gag-pol High levels of additive and synergic antiretroviral activity are obtained by using antiretroviral compounds (T1249, 3TC, RAL, or IDV) in PM1 cells stably expressing anti-host shRNAs (IPO7, HSPD1, or ATG16) or anti-HIV shRNAs (Pol, RT, or Nef) PubMed
    gag-pol Importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the active nuclear import of the intracellular HIV-1 reverse transcription complex (RTC) containing HIV-1 RT, IN, NC, MA, and Vpr PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14581, MGC138673

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of odontoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    importin-7
    Names
    RAN-binding protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006391.3NP_006382.1  importin-7

      See identical proteins and their annotated locations for NP_006382.1

      Status: REVIEWED

      Source sequence(s)
      AC055845, AC132192
      Consensus CDS
      CCDS31425.1
      UniProtKB/Swiss-Prot
      A6NNM5, B2R786, O95373, Q1RMF7, Q9H177, Q9NTE3
      Related
      ENSP00000369042.3, ENST00000379719.8
      Conserved Domains (1) summary
      COG5656
      Location:15997
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      9384652..9448127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      9469789..9533256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)